Yale scientists decipher 'wiring pattern' of cell signaling networks

New Haven, Conn. -- A team of scientists at Yale University has completed the first comprehensive map of the proteins and kinase signaling network that controls how cells of higher organisms operate, according to a report this week in the journal Nature.

The study is a breakthrough in understanding mechanisms of how proteins operate in different cell types under the control of master regulator molecules called protein kinases. Although protein kinases are already important targets of cancer drugs including Gleevec and Herceptin, until recently, it has been difficult to identify the proteins regulated by the kinases.

Led by Michael Snyder, Lewis B Cullman Professor of Molecular, Cellular and Developmental Biology, these researchers focused on the expression and relationship between proteins of the yeast cell "proteome," or the proteins that are active in a cell.

Protein kinases act as regulator switches and modify their target proteins by adding a phosphate group to them. This process, called "phosphorylation," results in altered activity of the phosphorylated protein. It is estimated that 30% of all proteins are regulated by this process.

Using technology developed in Snyder's laboratory, graduate students Jason Ptacek and Geeta Devgan used proteome microarrays to assay the thousands of different proteins in a yeast cell for targets of the protein kinases. The 82 unique kinases, representing the majority of master regulators in the yeast cell, were tested separately with the microarrays to determine which proteins were modified by each kinase.

From the wealth of information generated by these experiments Snyder's team constructed a complex map of the regulatory networks governing the functions and activities of the kinases in the y

Contact: Janet Rettig Emanuel
Yale University

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Smithsonian scientists show differing patterns of rainforest biodiversity
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Cornell scientists link E. coli bacteria to Crohns disease
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. ASBMB taps 8 scientists and 1 politician for top awards
7. UF, French scientists seek test to detect gene doping in athletes
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. Forsyth scientists gain new understanding of adult stem cell regulation
10. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
11. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis

Post Your Comments:

(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 8.8% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... SARASOTA, FL (PRWEB) , ... ... ... Inc. (RPS®) today announces publication of a United States multicenter, prospective clinical ... single use, disposable, point-of-care diagnostic test capable of identifying clinically significant acute ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... Netherlands and LAGUNA HILLS, Calif. ... Institute of Cancer Research, London (ICR) ... MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with ... known as MUK nine . The University of ... which is partly funded by Myeloma UK, and ICR will ...
(Date:10/10/2017)... (PRWEB) , ... October 10, ... ... development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed ... targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with ...
Breaking Biology Technology:
Cached News: