HOME >> BIOLOGY >> NEWS
Zebrafish may offer researchers powerful new tool for studying innate immunity

Tampa, FL (Oct. 18, 2004) -- For the first time, researchers have sequenced all 36 genes of novel receptors that appear to play a critical role in the innate immune protection of zebrafish an achievement that could lead to a better understanding of infectious diseases and certain cancers.

Their paper, titled "Resolution of the novel immune-type receptor gene cluster in zebrafish," appears online today in the Proceedings of the National Academy of Sciences.

"This is the most genetically complex system of innate immune receptors thus far described,"said principal investigator Gary Litman, PhD, Hines professor of pediatrics who works at the Children's Research Institute at the University of South Florida and All Children's Hospital. "They may be related to receptors in humans involved in natural killer cell function." Natural killer cells sense and kill malignant cells and cells infected with certain viruses.

The zebrafish, a small species of freshwater aquarium fish, increasingly serves as an animal model for the study of genetic diseases. Like humans, it has two types of immune systems innate and adaptive. Innate immune systems provide a first line of defense against foreign microorganisms. But, humans and other jawed vertebrates have also evolved more customized or adaptive immune systems, which use an arsenal of antibodies and T-cell receptors to fend off diverse pathogens and prevent repeat attacks.

Dr. Litman and his colleagues are trying to tease out details about the evolutionary transition from innate to adaptive immunity with powerful new biotechnology techniques.

They searched the genome of the zebrafish and identified a class of genes, called novel immune-type receptor (NITR) genes, which are predicted to be capable of recognizing a wide range of surface molecules. A portion of the NITR genes is very similar to variable region genes of antibodies and T-cell receptors, but the NITR genes do not undergo the compl
'"/>

Contact: Anne DeLotto Baier
abaier@hsc.usf.edu
813-974-3300
University of South Florida Health
18-Oct-2004


Page: 1 2

Related biology news :

1. Zebrafish: Its not your parents lab rat
2. Zebrafish and CHIP help untangle protein misfolding in brain disease
3. Zebrafish may hold key to improved cancer research
4. Zebrafish may hold key to understanding human nerve cell development
5. Zebrafish study yields observation of muscle formation
6. New blood test might offer early warning of deep belly fat
7. UCF nanoparticle offers promise for treating glaucoma
8. Lucky 13 as new gene discovery offers further hope for childhood blindness
9. Largest synthetic gene ever built offers insights into anti-malarial drug resistance
10. Soils offer new hope as carbon sink
11. Gene therapy offers new hope for treatment of peripheral neuropathy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... Texas (PRWEB) , ... September 05, 2018 , ... ... Facility Platform for a mAb manufacturing facility late last year, IPS-Integrated Project Services, ... for the manufacturing of autologous cell therapies. The iCON solution provides a pre-fabricated ...
(Date:8/31/2018)... SCOTTSDALE, Ariz. (PRWEB) , ... August 30, 2018 ... ... therapies, is now offering a complimentary cryogenic freezer program for new clients. The ... procedures. , The regenerative biologics from R3 Stem Cell consist of amniotic and ...
(Date:8/31/2018)... ... August 30, 2018 , ... USDM Life Sciences , the ... and healthcare industries, has received the 2018 Services Partner of the Year, Awarded for ... Box SVP of Business Development and Platform Sales, Niall Wall and received by USDM ...
Breaking Biology News(10 mins):
(Date:9/15/2018)... ... ... Nationally recognized public accounting and consulting firm Cherry Bekaert LLP ... Nashville practice, on her appointment to Launch Tennessee’s Board of Directors. , ... of the Firm’s Nashville practice in December 2017 . In this role, she oversees ...
(Date:9/12/2018)... ... September 11, 2018 , ... Leading regenerative ... of Feline Practitioners Conference (AAFP) later this month. The company’s CEO ... therapy for the treatment of chronic kidney disease in felines at a poster ...
(Date:9/7/2018)... ... September 05, 2018 , ... Now available on live stream, ... held on Sept. 19, 2018. With a panel of industry leaders from Harvard, Cornell, ... will reveal industry insights from experts in the field. Register today to be ...
(Date:9/7/2018)... ... September 06, 2018 , ... ... neuromuscular disease, has been validated to be as effective as manual pathology. The ... Staining in Frozen Muscle Biopsies,” was published in the Archives of Pathology & ...
Breaking Biology Technology:
Cached News: