Navigation Links
The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
Date:8/19/2007

Phase 2 Study to Explore the Efficacy of Novel Proteasome Inhibitor in

Patients with Relapsed and Refractory Multiple Myeloma

SOUTH SAN FRANCISCO, Calif. and NORWALK, Conn., Aug. 15 /PRNewswire/ -- The Multiple Myeloma Research Consortium (MMRC) and Proteolix, Inc. today announced the enrollment of the first patient in a multi-center Phase 2 clinical trial to study Proteolix's potent and selective proteasome inhibitor, carfilzomib (PR-171), in patients with relapsed and refractory multiple myeloma. Ten MMRC Member Institutions will participate in the study, under the MMRC leadership of Melissa Alsina, MD, H. Lee Moffitt Cancer Center & Research Institute. The nine additional sites are the City of Hope, Emory University, Cancer Center at Hackensack University Medical Center, Mayo Clinic, Princess Margaret/University Health Network, Saint Vincent's Comprehensive Cancer Center, University of Michigan, and Washington University.

The MMRC is the only research model of its kind that brings together 13 leading academic institutions to accelerate the development of novel and combination treatments for multiple myeloma, an incurable cancer of the plasma cell.

"Proteasome inhibitors are an important class of drugs for the treatment of multiple myeloma and we are proud to work with Proteolix to advance the clinical development of carfilzomib," said Kathy Giusti, Founder and Chief Executive Officer of the MMRC. "This trial and the others the MMRC are facilitating underscore our commitment to bring better, more effective treatments to myeloma patients as quickly as possible."

The trial will evaluate the overall response rate (ORR) for two cycles of carfilzomib in patients with multiple myeloma who have previously received specific FDA-approved therapies, have relapsed after two or more of such therapies, and are refractory to the most recently received therapy. Secondary objectives of this study include safety and tolerability, clinica
'/>"/>

SOURCE Proteolix

Copyright©2007 PR Newswire.

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. Mx4000 Multiplex Quantitative PCR System*,PPP
2. QIAGEN Multiplex PCR Handbook
3. Fully automated DNA purification and efficient multiplex PCR for analysis of microsatellite loci
4. QIAGEN Multiplex PCR Kit
5. Measuring multiple apoptosis parameters with the Agilent 2100 bioanalyzer
6. Microfluidic analysis of multiplex PCR products for the genotyping of Helicobacter pylori
7. A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis
8. Real-Time Multiplex PCR from Genomic DNA Using the iCycler iQ Detection System
9. Correlation of Bio-Plex Suspension Array Reader Validation With Multiplex Cytokine Assay Performance, Rev A
10. Principles of Curve Fitting for Multiplex Sandwich Immunoassays, Rev B
11. Development of a Multiplex Bead-Based Assay for Antibody Screening of a Nonhuman Primate Colony on the Bio-Plex System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2008)...-- Intellect Neurosciences, Inc. ( OTC Bulletin ...ed on development of disease-modifying therapeutic...mer,s disease released today the following Letter ...n and CEO. , , Dear Shareholders, , ,... of Intellect Neurosciences Inc., which I helped f...
(Date:11/20/2008)...Call/ -- BioSpecifics,Technologies Corp. (OTC Bul...eveloping first in class collagenase-based product...Thomas Wegman, will present at the upcoming Piper,...sday, December 2, 2008, at,4:30pm ET at the New Y...webcast of the presentation can be accessed at, h...
(Date:11/20/2008)...-FirstCall/ -- Par Pharmaceutical Companies, Inc. ...ict Court for the District of New Jersey last nigh...a temporary restraining order (TRO) halting sales ...e inhaled solution). In conjunction with the Cour...t it too would halt all sales of its authorized ge...
(Date:11/20/2008)... -- Neurocrine Biosciences, Inc.,(Nasdaq: NBIX ... Chief,Executive Officer of Neurocrine Bioscience...fray Health Care Conference in New York. , ...Tuesday, December 2,2008 at 1:30 p.m. Eastern Ti...tation will be simultaneously webcast and may be a...
Breaking Biology Technology:Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO 2Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO 3Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO 4Intellect Neurosciences, Inc. Issues Letter to Shareholders From Its Chairman and CEO 5Par Pharmaceutical Halts Shipment of Budesonide Inhalation Suspension 2
Editor,s Note: During July 2003, two British education officals visited Madison to determine whether the "Wisconsin Idea" can be exported. At a time when many Wisconsin leaders are studying how to
...ems has received required regulatory approvals for...orporation. The company has agreed to divest of ...GE Medical Systems, a medical imaging equipment ma...into its GE Medical Systems Information Technologi...The final required regulatory approvals, including...
...Care is planning to open a new state-of-art health...al hospital will include the latest in digital ima...th patients and physicians will benefit from enter...images across its integrated delivery network (IDN... nationally recognized leader in efforts to improv...
...h your Internet connection? , ,MADISON, WI - McD...less fidelity (Wi-Fi) Internet connections in five...program. These Milwaukee locations join select McD... Metropolitan New York City, Greater Chicagoland, ...ternet service. , ,Customers can purchase an hour ...
Other Biology Technology:Aurora Selects New Imaging Technology 2Wisconsin McDonalds Go Wireless 2
(Date:11/20/2008)... Nov. 19 DigitalPersona, Inc., the...announced DigitalPersona,Personal 4.0, an easy-to...mily,members and business users. DigitalPersona P...e to use biometrics, letting people use their fing...mail, banking, shopping, and other Web,sites -- t...
(Date:11/20/2008)...from the University of Pittsburgh published in the...de evidence of the first stages of the evolution o...nd females developed from hermaphroditic ancestors... because the majority of animal species developed ...ate too long ago for scientists to observe the tra...
(Date:11/20/2008)... Inc., (NMS), an Austin-based startup cofounded by...Health Science Center at Houston (UTHSC-Houston), ... and other medications, has received a record $3.5... Emerging Technology Fund (ETF). , NMS was one o...h were announced by Texas Gov. Rick Perry on Tuesd...
(Date:11/20/2008)...ailable in German . , Halle/Saale. For the...ive overview of which alien species are present in...vironment and society. More than 11,000 alien spec...en Invasive Species Inventory for Europe), a uniqu...uropean scientists, funded by the European Union t...
Breaking Biology News(10 mins):DigitalPersona Places Identity Protection at People's Fingertips 2DigitalPersona Places Identity Protection at People's Fingertips 3Two from one: Pitt research maps out evolution of genders from hermaphroditic ancestors 2Texas invests record $3.5 million in startup cofounded by UT's Mauro Ferrari 211,000 alien species invade Europe 2Scientists ask whether microscaffolding can help stem cells rebuild brain after stroke damage 2840 1Scientists ask whether microscaffolding can help stem cells rebuild brain after stroke damage 2840 2Researchers pilot new electronic system for infectious illness 16444 1Researchers pilot new electronic system for infectious illness 16444 2Safer easier system for remote explosive detection 4506 1Safer easier system for remote explosive detection 4506 2Slow federal action to oversee nanotechnology leaves room at the bottom 4503 1
...ated with osteoarthritis and skeletal deformities ...venting the onset of osteoarthritis in adult mice,...ospital. The matrilin-3 gene plays a role in early...n adulthood and prevents osteoarthritis later in l...een linked to certain skeletal disorders and hand ...
...ignificantly improved the cardiovascular and exerc...gh altitude, mostly because the drug helped some p...hers showed little change. Sildenafil provided no ...enafil at altitude collectively lowered the time i...placebo trials at altitude. The cyclists also sign...
...ta researchers have found a group of cells in the ...on T-cells, cells that help fight infection. , The...of the journal Immunity, released today. , "This ...esponse will help in studying and developing treat...l system," said Stephen McSorley, Ph.D., professor...
...sity of Virginia Health System have shown for the ...nucleic acid) in muscle cells can reverse myotonic...ophy in adults. , About 40,000 people in the Unit...The disease can cause a slow, progressive wasting ... insulin resistance. Many people don,t know they h...
Other Biology News:Matrilin-3 gene discovered to prevent onset of osteoarthritis 2Matrilin-3 gene discovered to prevent onset of osteoarthritis 3Viagra improves high altitude exercise performance up to 45% for some 2Viagra improves high altitude exercise performance up to 45% for some 3Viagra improves high altitude exercise performance up to 45% for some 4Toxic molecule may cause most common type of muscular dystrophy 2
Eppendorf Thermomixer R from Eppendorf North America
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV.
...e primers are designed for sequencing inserts clon...g the SP6, T7, or T3 RNA polymerase promoters, or ... a concentration of 0.1 µg/µl in water. ...ing reactions using SequiTherm™ EXCEL™ I...
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo
Biology Products: