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$3.13 million for Structural Genomics Research awarded to Hauptman-Woodward Medical Research Institute, University at Buffalo

BUFFALO, NY -- The Hauptman-Woodward Medical Research Institute (HWI) and the University at Buffalo have received grants totaling $3.13 million to develop new, high-speed methods to determine the molecular structure of proteins.

The funding is part of a $25 million center grant awarded to the Northeast Structural Genomics (NESG) Consortium composed of researchers from UB, HWI, Cornell University, Columbia University, Yale University, University of Toronto, Ontario Cancer Institute, Pacific Northwest National Laboratories, and Rutgers University, home to the principal investigator on the project, Gaetano T. Montelione.

The consortium was established in response to the National Institutes of Health's Protein Structure Initiative, funded through the National Institute of General Medical Sciences (NIGMS). The initiative aims to capitalize on discoveries generated by the Human Genome Project.

The NESG Consortium is one of seven pilot research centers in structural genomics, a new field dedicated to determining gene function by defining the protein structure encoded in a gene's DNA sequence. The NIH initiative aims to target proteins from various model organisms, including the fruit fly, yeast, roundworm and certain human proteins.

The consortium will use both X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy to determine protein structures. Knowing the molecular structure of proteins is essential for designing new drugs to treat, prevent and cure disease.

At Hauptman-Woodward, George DeTitta, Ph.D., HWI executive director and CEO, who also is a UB research professor, and Joseph Luft, HWI senior research scientist, will receive $1.75 million over the next five years for their work in crystal-growth methods and techniques. It will use a newly developed high-throughput robotics laboratory that will allow researchers to obtain crystals for X-ray structural analysis for a large number of different proteins in a short time
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Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x 1417
University at Buffalo
21-Dec-2000


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