dren performed significantly better on both the three times a day and the extended-release medications in all settings than when receiving the placebo. The extended-release formulation maintained its effectiveness even after 12 hours in both the laboratory and home settings, findings indicated. Ratings were similar for both active formulations.

Parents, teachers and children in the study also took part in a concurrent regimen of behavior modification. Combining behavioral modification with medication is the best way to treat ADHD, Pelham noted.

Assessing the clinical trial itself, Pelham said: "Because it is given only once per day, Concerta should improve compliance with ADHD children's medication regimens and afford smoother treatment effects throughout the day."

Pelham acknowledged that some ADHD children do not need medication in the evening, and that some parents prefer not to use medication for their ADHD children. "For those who do, however, Concerta would appear to be a good choice of stimulant medications as part of a total treatment package for ADHD," he said.

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Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
4-Jun-2001

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