1st data show CRESTOR highly effective at lowering LDL-C in patients with type 2 diabetes

Seville, Spain, Sunday 18 April 2004. New data show CRESTORTM (rosuvastatin) provides superior reductions in a major cardiovascular risk factor, LDL-cholesterol (LDL-C), in patients with type 2 diabetes and dyslipidaemia compared to atorvastatin.1-3 Results from the CORALL study demonstrated that for each dose of CRESTOR, LDL-C was reduced significantly more than with double the dose of atorvastatin; LDL-C was reduced by 46%, 51% and 54% with CRESTOR 10mg, 20mg and 40mg respectively compared to 41%, 46% and 48% with atorvastatin 20mg, 40mg and 80mg, respectively (all p<0.05).1 CORALL is one of three new studies with CRESTOR presented at the European Atherosclerosis Society (EAS) Congress in this patient population.1-3

People with type 2 diabetes are three times more likely to die from a cardiovascular event than non-diabetics with the same cholesterol level and up to 80% die of cardiovascular disease.4 Reducing high levels of LDL-C is recognised as one of the primary treatment targets for type 2 diabetics5, 6 and lowering LDL-C with statin treatment has been demonstrated to be effective in reducing cardiovascular events in these patients.7-10 The latest US and European guidelines now set the low and challenging LDL-C goal of <2.5 mmol/L (100mg/dL) for these high risk patients.5, 6 A growing body of evidence suggests that additional prevention of major cardiovascular events may be achieved through lowering LDL-C levels below what was previously accepted as sufficient. A recent study has confirmed that a statin providing more effective reductions in LDL-C (by 42%) leads to greater protection against death or major cardiovascular events than standard statin treatment.11

Results presented today from the ANDROMEDA study show that low doses of CRESTOR reduced LDL-C by at least 50% and got more than 90% of patients with type 2 diabetes and dyslipidaemia to their new European LDL-C goal of <2.5 mmol/L.2 Also in this study, CRESTOR 10mg and 20mg

Contact: Francesca Zino
Shire Health International

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