Professor Magloire has contributed several seminal findings in the field of odontoblast biology. He has characterized the replacement population of odontoblasts involved in the formation of reparative dentin and developed a novel culture system to study the responses of these cells to various growth factors in vitro. More recently, he has described profiles of gene expression in odontoblasts using two original culture systems from pulp tissue and thick slices of human teeth. These in vitro studies allowed him to show the role of TGFβ during dentin repair and, particularly, the target molecules such as a new "dental" proteoglycan: osteoadherin (SLRP). His group was the first to identify the presence of integrins (αVβ3) in odontoblast membranes. His group again, through a subtractive cDNA bank between odontoblasts and pulpal cells, succeeded in cloning new genes (Smile and Hugo) involved in odontoblast differentiation. In addition to these new genes, he detected, for the first time, neuronal guidance/adhesion molecules (reelin, semaphorin 7), expressed by odontoblasts, whose role is under analysis (control of the relationship nerve/odontoblast). He kept in mind that odontoblasts could have a putative role in the transduction of signals during dentin sensitivity, and he was the first researcher identifying and characterizing the mechanosensitivity of potassium ion channels of human odontoblasts (KCa and TREK-1). These channels, open by stretch of the cell membrane, could be involved in the transfer of information between odontoblasts (through the dentin fluid) and the surrounding pulp tissue. Recently, he showed the exp
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Contact: Linda T. Hemphill
lhemphill@iadr.org
703-299-8091
International & American Association for Dental Research
9-Mar-2005