HOME >> MEDICINE >> NEWS
A key to depression

PROZAC stimulates the birth of new brain cells in rats, say scientists from New Jersey. The finding gives clues to what causes depression in people, how drugs like Prozac relieve it and why the effect takes so long to kick in.

Just over a year ago, researchers showed that people grow new neurons all the time. This overturned a long-held belief that brain cells, unlike cells in other parts of the body, are not replaced when they die.

Barry Jacobs and Casimir Fornal at Princeton University put together findings from several different brain studies. They knew, for instance, that depressed people have a smaller hippocampus-a structure that is involved in learning and memory-than healthy people.

They also knew that chronic stress can slow neuron birth, or neurogenesis, in the brains of rodents. Stress is thought to contribute to depression. "A little light went on in my head," says Jacobs. "It just occurred to me that maybe this is what depression is all about."

Jacobs and Fornal went on to show that activating one type of receptor for the neurotransmitter serotonin in rats' brains increased the birth of neurons. So they decided to see if Prozac, which belongs to a class of drugs known as selective serotonin re-uptake inhibitors (SSRIs), would have the same effect. SSRIs prevent serotonin from being mopped up, leaving more of it around to transmit messages.

The team gave daily injections of Prozac to five rats for 21 days. Five control rats were injected with saline. During the final 7 days, they also gave the rats a chemical called BrdU, which labels new neurons. When they examined the rats' brains, 69 per cent more new neurons had appeared in the brains of the Prozac-treated rats compared with the controls.

Jacobs and Fornal believe that the waxing and waning of neurogenesis in the hippocampus may be an important factor in explaining why people slump into depression and why they recover with SSRIs. It may also explain why Prozac takes severa
'"/>

Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-20-7331-2751
New Scientist
2-Nov-1999


Page: 1 2

Related medicine news :

1. Single mothers at higher risk for depression
2. Treating depression helps slow physical decline in older adults, study shows
3. Pregnant women should exercise to keep depression away
4. Even mild depression increases long-term mortality in heart failure
5. Mood elevating hormone may trigger depression and heart problems
6. Study reveals frequent non-guideline treatment of late-life depression
7. York study tests enhanced care for depression patients
8. Is caesarean section linked to postnatal depression?
9. Over-the-counter supplement appears effective in treatment of midlife-onset depression
10. Mothers depression associated with increased risk of childs antisocial behavior
11. Best treatment for mild or moderate depression unclear

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)... ... , ... Ogawa World USA introduced the first of its kind Ogawa ... Application. The Smart 3D combines the best in technological advancement, design, and massage capability ... specialized massage program, each user has a tailored experience unparalleled by any other massage ...
(Date:5/3/2016)... ... May 03, 2016 , ... Intrigma, the ... that Legacy Health is expanding its use of Intrigma’s cloud-based physician scheduling solution, ... initial proof of concept. The Portland, Oregon based health system conducted a one-year ...
(Date:5/3/2016)... , ... May 03, 2016 , ... ... innovative information technology (IT) solutions and digital consulting services to the federal government, ... Services (EITS) Indefinite Delivery / Indefinite Quantity (ID/IQ) contract in support of the ...
(Date:5/3/2016)... ... 2016 , ... Huntington Beach orthopedic doctor , Dr. Rick Pospisil, now ... used to diagnose and treat joint problems. During this procedure, Dr. Pospisil makes a ... lighting system and lens that illuminate and magnify the various structures in the joint ...
(Date:5/3/2016)... ... 2016 , ... Branches, Inc. is proud to have been selected as a ... in South Miami. Macy’s is a wonderful community partner and has helped to support ... mentoring, enrichment and academic support to elementary students 5 days a week. Summer Shade, ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... LAKE OSWEGO, Ore. , May 3, 2016 /PRNewswire/ ... about the importance of extending care beyond the implant ... Scientific Sessions, May 4-7 in San Francisco ... tasked with continually delivering the highest quality of patient ... ensuring patients are cared for each and every tomorrow," ...
(Date:5/3/2016)... 2016 Pharmaceutical giant Johnson & ... a woman who says its talc-based powder products caused ... Ristesund $5 million in compensatory damages and $50 ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , This is the ... In February, the same court awarded $72 million to ...
(Date:5/3/2016)... Calif. , May 3, 2016  Specialty ... teaching tool that shows how a cleanroom works. ... classroom discussions about science and technology. ... said, "As a technology company, SSF enthusiastically supports ... to help educators foster the next generation of ...
Breaking Medicine Technology:
Cached News: