HOME >> MEDICINE >> NEWS
A key to depression

PROZAC stimulates the birth of new brain cells in rats, say scientists from New Jersey. The finding gives clues to what causes depression in people, how drugs like Prozac relieve it and why the effect takes so long to kick in.

Just over a year ago, researchers showed that people grow new neurons all the time. This overturned a long-held belief that brain cells, unlike cells in other parts of the body, are not replaced when they die.

Barry Jacobs and Casimir Fornal at Princeton University put together findings from several different brain studies. They knew, for instance, that depressed people have a smaller hippocampus-a structure that is involved in learning and memory-than healthy people.

They also knew that chronic stress can slow neuron birth, or neurogenesis, in the brains of rodents. Stress is thought to contribute to depression. "A little light went on in my head," says Jacobs. "It just occurred to me that maybe this is what depression is all about."

Jacobs and Fornal went on to show that activating one type of receptor for the neurotransmitter serotonin in rats' brains increased the birth of neurons. So they decided to see if Prozac, which belongs to a class of drugs known as selective serotonin re-uptake inhibitors (SSRIs), would have the same effect. SSRIs prevent serotonin from being mopped up, leaving more of it around to transmit messages.

The team gave daily injections of Prozac to five rats for 21 days. Five control rats were injected with saline. During the final 7 days, they also gave the rats a chemical called BrdU, which labels new neurons. When they examined the rats' brains, 69 per cent more new neurons had appeared in the brains of the Prozac-treated rats compared with the controls.

Jacobs and Fornal believe that the waxing and waning of neurogenesis in the hippocampus may be an important factor in explaining why people slump into depression and why they recover with SSRIs. It may also explain why Prozac takes severa
'"/>

Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-20-7331-2751
New Scientist
2-Nov-1999


Page: 1 2

Related medicine news :

1. Single mothers at higher risk for depression
2. Treating depression helps slow physical decline in older adults, study shows
3. Pregnant women should exercise to keep depression away
4. Even mild depression increases long-term mortality in heart failure
5. Mood elevating hormone may trigger depression and heart problems
6. Study reveals frequent non-guideline treatment of late-life depression
7. York study tests enhanced care for depression patients
8. Is caesarean section linked to postnatal depression?
9. Over-the-counter supplement appears effective in treatment of midlife-onset depression
10. Mothers depression associated with increased risk of childs antisocial behavior
11. Best treatment for mild or moderate depression unclear

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... ... 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join ... wage raise to $12 an hour by 2020 and then adjusting it yearly to increase ... of the minimum wage, assure the wage floor does not erode again, and make future ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
Breaking Medicine Technology:
Cached News: