HOME >> MEDICINE >> NEWS
A pair of discoveries helps unravel complex genetics of inflammatory bowel disease

he disease, was examined using several genetic techniques. They found a clear association between IBD and the MDR1 gene. Like NFKB1, mouse genetic studies similarly suggested that the MDR1 gene was important in colitis, alerting researchers to the potential importance of MDR1 to human IBD.

"Taken together, these new discoveries combine with the original NOD2 gene discovery and will hopefully lead to ways to intervene and possibly prevent IBD from occurring," says Brant. In addition to their association with IBD, Brant hopes the new discoveries will prove useful to researchers working on different diseases.

Crohn's disease and ulcerative colitis primarily affect the intestines, resulting in pain, severe diarrhea, intestinal bleeding, weight loss and fever. Symptoms vary in severity and duration; some patients suffer from frequent prolonged attacks, and others have fewer recurrences. The disease usually starts in the adolescent or young adult years. In ulcerative colitis, the inner lining of the colon is inflamed. People with Crohn's disease have similar inflammation, but it extends deeper into the intestinal wall and can also involve the small and large intestines.

Researchers from Johns Hopkins University, University of Chicago, University of Pittsburgh and the Cleveland Clinic participated in both studies, and researchers from University of Toronto and New York University participated in the NFKB1 study. These studies were funded by the National Institutes of Health, the Crohn's and Colitis Foundation of America, the Meyerhoff IBD Center, the Stewart W. Bainum family, the Reva and David Logan Foundation, the Scaife Family Foundation, the Israeli Society of Gastroenterology, Toyobo Biotechnology Foundation, the Crohn's and Colitis Foundation of Canada, the Canadian Association of Gastroenterology, the Canadian Institutes of Health Research, , and the Gastrointestinal Research Foundation.

Functional Annotation of a Novel NFKB1
'"/>

Contact: Trent Stockton
tstockt1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
19-Dec-2003


Page: 1 2 3 4

Related medicine news :

1. Alzheimers disease - recent discoveries pave the way toward new treatments
2. California chemist wins national award for drug discoveries
3. NIH-funded UCSD rheumatic diseases center to facilitate collaboration, speed discoveries
4. Virginia Tech students discoveries can help prevent water-borne diseases
5. Japanese chemist wins U.S. award for molecular discoveries
6. Stony Brook chemist wins national award for drug discoveries
7. 7,000 Pharmaceutical scientists to share latest drug developments and discoveries
8. Protein that helps skin cancer spread identified by Stanford researchers
9. Treating depression helps slow physical decline in older adults, study shows
10. Laughter helps blood vessels function better
11. Chemists synthesize molecule that helps body battle cancers, malaria

Post Your Comments:
(Date:4/1/2015)... This year for Oral Cancer Awareness Month, Herald ... an Open House to offer complimentary oral cancer screenings on ... An appointment is required and can be secured by calling ... In addition, Herald Square Dental and The Denture Center are ... April at the reduced cost of $39 (regularly $78). Half ...
(Date:4/1/2015)... The panel session will look at the need for ... program that can grow in a privacy-friendly manner, thus ... line. This topic has taken on even greater relevance ... dongles aren’t as secure as the automobile industry thought ... Progressive’s Snapshot dongles contained very significant security flaws, which ...
(Date:4/1/2015)... Orlando, FL (PRWEB) April 01, 2015 ... dedicated to providing the latest information on the top ... attempt to set the Guinness World Records title for ... as part of the 1st annual Baby Bellies & ... at 10am, and the Guinness World Record will commence ...
(Date:4/1/2015)... 2015 BioPlus Specialty Pharmacy ... has released a new app to keep health care ... chronic hepatitis C virus (HCV) infection. This ‘HCV Treatment ... from the American Association for the Study of Liver ... new direct-acting oral medications to treat HCV have been ...
(Date:4/1/2015)... Dr. Daniel C. Stewart ... to discuss the benefits of the LANAP® treatment over ... periodontal disease. People who live in Howard County, and ... can now visit Dr. Stewart, a Maryland dentist, for ... the LANAP® protocol, which is a laser gum surgery ...
Breaking Medicine News(10 mins):Health News:Herald Square Dental Celebrates Oral Cancer Awareness Month 2Health News:TU-Automotive: Office of The Privacy Commissioner of Canada To Set Out Privacy Considerations Surrounding UBI Products 2Health News:TU-Automotive: Office of The Privacy Commissioner of Canada To Set Out Privacy Considerations Surrounding UBI Products 3Health News:Baby Bellies & Beyond Attempts To Break Guinness World Records For “Mommy Moments” Largest Gathering Of Pregnant Women April 19 Outside Florida Hotel & Conference Center 2Health News:Baby Bellies & Beyond Attempts To Break Guinness World Records For “Mommy Moments” Largest Gathering Of Pregnant Women April 19 Outside Florida Hotel & Conference Center 3Health News:BioPlus Specialty Pharmacy Releases ‘HCV Treatment Path’ App for Hepatitis C Providers 2Health News:Dr. Daniel C. Stewart Offers Columbia Area Residents an Informational Seminar in April About Less Invasive Gum Disease Treatment Now Available at Smile Savers Dentistry 2Health News:Dr. Daniel C. Stewart Offers Columbia Area Residents an Informational Seminar in April About Less Invasive Gum Disease Treatment Now Available at Smile Savers Dentistry 3
(Date:4/1/2015)... 2015 Trinity Biotech plc (Nasdaq: ... diagnostic products for the point-of-care and clinical laboratory ... its wholly-owned subsidiary (the "Issuer"), intends to offer, ... aggregate principal amount of Exchangeable Senior Notes due ... buyers pursuant to Rule 144A under the Securities ...
(Date:4/1/2015)... , April 1, 2015  Hologic, Inc. (NASDAQ: ... of the 2.00% Convertible Exchange Senior Notes due 2037 ... Wilmington Trust Company, the trustee, paying agent and conversion ... convert the notes.  This conversion right is subject to ... dated as of December 10, 2007, as supplemented by ...
(Date:4/1/2015)... and ASPEN, Colo. , April ... with the Chris Klug Foundation (CKF), is pleased to sponsor ... being accepted for the award, which will recognize two ... life, whether it is a career accomplishment, participation in ... life with family and loved ones. ...
Breaking Medicine Technology:Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 2Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 3Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 4Hologic Delivers Notice that Holders of 2.00% Convertible Exchange Senior Notes Due 2037 are Eligible to Convert 2Astellas Teams Up with The Chris Klug Foundation on the Bounce Back Award to Recognize Extraordinary Transplant Recipients 2Astellas Teams Up with The Chris Klug Foundation on the Bounce Back Award to Recognize Extraordinary Transplant Recipients 3
Cached News: