HOME >> MEDICINE >> NEWS
A pair of discoveries helps unravel complex genetics of inflammatory bowel disease

he disease, was examined using several genetic techniques. They found a clear association between IBD and the MDR1 gene. Like NFKB1, mouse genetic studies similarly suggested that the MDR1 gene was important in colitis, alerting researchers to the potential importance of MDR1 to human IBD.

"Taken together, these new discoveries combine with the original NOD2 gene discovery and will hopefully lead to ways to intervene and possibly prevent IBD from occurring," says Brant. In addition to their association with IBD, Brant hopes the new discoveries will prove useful to researchers working on different diseases.

Crohn's disease and ulcerative colitis primarily affect the intestines, resulting in pain, severe diarrhea, intestinal bleeding, weight loss and fever. Symptoms vary in severity and duration; some patients suffer from frequent prolonged attacks, and others have fewer recurrences. The disease usually starts in the adolescent or young adult years. In ulcerative colitis, the inner lining of the colon is inflamed. People with Crohn's disease have similar inflammation, but it extends deeper into the intestinal wall and can also involve the small and large intestines.

Researchers from Johns Hopkins University, University of Chicago, University of Pittsburgh and the Cleveland Clinic participated in both studies, and researchers from University of Toronto and New York University participated in the NFKB1 study. These studies were funded by the National Institutes of Health, the Crohn's and Colitis Foundation of America, the Meyerhoff IBD Center, the Stewart W. Bainum family, the Reva and David Logan Foundation, the Scaife Family Foundation, the Israeli Society of Gastroenterology, Toyobo Biotechnology Foundation, the Crohn's and Colitis Foundation of Canada, the Canadian Association of Gastroenterology, the Canadian Institutes of Health Research, , and the Gastrointestinal Research Foundation.

Functional Annotation of a Novel NFKB1
'"/>

Contact: Trent Stockton
tstockt1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
19-Dec-2003


Page: 1 2 3 4

Related medicine news :

1. Alzheimers disease - recent discoveries pave the way toward new treatments
2. California chemist wins national award for drug discoveries
3. NIH-funded UCSD rheumatic diseases center to facilitate collaboration, speed discoveries
4. Virginia Tech students discoveries can help prevent water-borne diseases
5. Japanese chemist wins U.S. award for molecular discoveries
6. Stony Brook chemist wins national award for drug discoveries
7. 7,000 Pharmaceutical scientists to share latest drug developments and discoveries
8. Protein that helps skin cancer spread identified by Stanford researchers
9. Treating depression helps slow physical decline in older adults, study shows
10. Laughter helps blood vessels function better
11. Chemists synthesize molecule that helps body battle cancers, malaria

Post Your Comments:
(Date:7/6/2015)... ... , ... Diabetes affects many of us and the Glycemic Load and Alkaline ... majority of which are Type 2. However, eight million do not know they have ... prediabetes (abnormally high blood sugar levels). Without reductions in blood sugar levels and in ...
(Date:7/6/2015)... ... ... Thanks to donations and a generous grant from the GAR Foundation, ... hospice patients and adult day center participants. , The Music & Memory program is ... their families and volunteers. Music & Memory is a non-profit organization that helps provide ...
(Date:7/6/2015)... Harlingen, Texas (PRWEB) , ... July 06, 2015 , ... ... a thought-provoking look into the economic transformation associated with the U.S. economy over the ... macroeconomic consequences associated with its use. In many ways, the book is a time ...
(Date:7/5/2015)... Minneapolis, MN (PRWEB) , ... July 06, 2015 ... ... in the ancillary benefits market, is excited to announce the next generation of ... Plus and Advantage plans to now include two network options—Maximum Allowable Charge (MAC) ...
(Date:7/5/2015)... (PRWEB) , ... July 06, 2015 , ... City Sports, ... City Sports will co-produce two training clinics for first-time triathletes this summer with ethos, ... will take place on Thursday, July 9, at 6:00 p.m. at the North End ...
Breaking Medicine News(10 mins):Health News:115 Million in the U.S. could beat diabetes with the help of a new app 2Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 2Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 3Health News:Music & Memory Program Brings Joy and Excitement to Hospice Patients 4Health News:New Book Brings Reveals The Repercussions Associated With The Global Economy 2Health News:Security Life Insurance Company of America Launches the Next Generation of PrimeStar Individual Dental Insurance Plans 2Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 2Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 3
(Date:7/3/2015)... According to a new ... Management Market ECG, Implantable Loop Recorder, Manual Event ... Dual Chamber Pacemaker, CRT-D, CRT-P - Global Forecast ... Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices ... 2020 from $21,137.7 Million in 2015, at a ...
(Date:7/3/2015)... , July 3, 2015 Redwood ... Broda Technologies Co., Ltd., operating in both the US ... company,s proprietary IntelliGel ® supramolecular hydrogel technology in ... and other ophthalmic therapies. The Broda technology offers many ... is a free-forming liquid and with low concentrations of ...
(Date:7/2/2015)... July 2, 2015 ResMed Inc. (NYSE: RMD ... and fiscal year ended June 30, 2015 results on Thursday, ... close. A press release with ResMed,s results will be issued ... host a webcast to discuss operating results and future outlook. ... 1:30 p.m. US Pacific Time and the live webcast of ...
Breaking Medicine Technology:Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 2Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 3Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 4Redwood Pharma Licenses Novel Hydrogel Drug Delivery Technology From Broda Technologies 2ResMed to Announce Fourth Quarter and Fiscal Year-End 2015 Results 2
Cached News: