HOME >> MEDICINE >> NEWS
A pair of discoveries helps unravel complex genetics of inflammatory bowel disease

he disease, was examined using several genetic techniques. They found a clear association between IBD and the MDR1 gene. Like NFKB1, mouse genetic studies similarly suggested that the MDR1 gene was important in colitis, alerting researchers to the potential importance of MDR1 to human IBD.

"Taken together, these new discoveries combine with the original NOD2 gene discovery and will hopefully lead to ways to intervene and possibly prevent IBD from occurring," says Brant. In addition to their association with IBD, Brant hopes the new discoveries will prove useful to researchers working on different diseases.

Crohn's disease and ulcerative colitis primarily affect the intestines, resulting in pain, severe diarrhea, intestinal bleeding, weight loss and fever. Symptoms vary in severity and duration; some patients suffer from frequent prolonged attacks, and others have fewer recurrences. The disease usually starts in the adolescent or young adult years. In ulcerative colitis, the inner lining of the colon is inflamed. People with Crohn's disease have similar inflammation, but it extends deeper into the intestinal wall and can also involve the small and large intestines.

Researchers from Johns Hopkins University, University of Chicago, University of Pittsburgh and the Cleveland Clinic participated in both studies, and researchers from University of Toronto and New York University participated in the NFKB1 study. These studies were funded by the National Institutes of Health, the Crohn's and Colitis Foundation of America, the Meyerhoff IBD Center, the Stewart W. Bainum family, the Reva and David Logan Foundation, the Scaife Family Foundation, the Israeli Society of Gastroenterology, Toyobo Biotechnology Foundation, the Crohn's and Colitis Foundation of Canada, the Canadian Association of Gastroenterology, the Canadian Institutes of Health Research, , and the Gastrointestinal Research Foundation.

Functional Annotation of a Novel NFKB1
'"/>

Contact: Trent Stockton
tstockt1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
19-Dec-2003


Page: 1 2 3 4

Related medicine news :

1. Alzheimers disease - recent discoveries pave the way toward new treatments
2. California chemist wins national award for drug discoveries
3. NIH-funded UCSD rheumatic diseases center to facilitate collaboration, speed discoveries
4. Virginia Tech students discoveries can help prevent water-borne diseases
5. Japanese chemist wins U.S. award for molecular discoveries
6. Stony Brook chemist wins national award for drug discoveries
7. 7,000 Pharmaceutical scientists to share latest drug developments and discoveries
8. Protein that helps skin cancer spread identified by Stanford researchers
9. Treating depression helps slow physical decline in older adults, study shows
10. Laughter helps blood vessels function better
11. Chemists synthesize molecule that helps body battle cancers, malaria

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/21/2017)... Helena, AL (PRWEB) , ... July 21, 2017 ... ... that offers insurance assistance and financial planning services to communities in the greater ... that promises to provide resources to underprivileged young people in the region. , ...
(Date:7/21/2017)... ... , ... Hospital M&A activity slowed in the second quarter of 2017, according ... to 23 in the second quarter, up 15% from the 20 publicly announced acquisitions ... in the year-ago second quarter. Only four of the transactions disclosed a purchase price ...
(Date:7/21/2017)... NJ (PRWEB) , ... July 21, 2017 , ... ... has received a $5,000 grant from the C. R. Bard Foundation, ... Day Center at Somerset Hills , a service available through the nonprofit home ...
(Date:7/21/2017)... ... , ... West Dermatology is pleased to announce the newest addition to their ... Vu will join West Dermatology’s large network of medical and cosmetic dermatology practices, bringing ... and more. She graduated from the University of Florida College of Medicine Physician Assistant ...
(Date:7/20/2017)... Viejo, CA (PRWEB) , ... July 20, 2017 , ... ... when placed between two clips in the FCPX timeline. This effect isolates horizontal and ... transition in this package contains either a rotating or flipping animation and can be ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... RESEARCH TRIANGLE PARK, N.C. , July 21, 2017 ... ) announced today that it will report its second ... Thursday, July 27, 2017. ... July 27, 2017, at 9:00 a.m. Eastern Time.  The ... dialing 1-970-315-0533.  A rebroadcast of the teleconference will be ...
(Date:7/20/2017)... -- Prime Therapeutics LLC (Prime) released this statement from its Chief ... for Clinical and Economic Review,s (ICER) public meeting ... of abuse-deterrent formulations (ADF) of opioids. Prime was the sole ... "The ICER data ... use of abuse-deterrent formulations (ADF) in opioids in terms of ...
(Date:7/15/2017)... Inc., a Philadelphia -based biotechnology company developing ... completion of a $12.7 million Series A financing round. The ... the participation of existing investors. ... New Ventures III and our current investors, and view the ... our platform technology to transform the course of PD and ...
Breaking Medicine Technology:
Cached News: