HOME >> MEDICINE >> NEWS
A pair of discoveries helps unravel complex genetics of inflammatory bowel disease

he disease, was examined using several genetic techniques. They found a clear association between IBD and the MDR1 gene. Like NFKB1, mouse genetic studies similarly suggested that the MDR1 gene was important in colitis, alerting researchers to the potential importance of MDR1 to human IBD.

"Taken together, these new discoveries combine with the original NOD2 gene discovery and will hopefully lead to ways to intervene and possibly prevent IBD from occurring," says Brant. In addition to their association with IBD, Brant hopes the new discoveries will prove useful to researchers working on different diseases.

Crohn's disease and ulcerative colitis primarily affect the intestines, resulting in pain, severe diarrhea, intestinal bleeding, weight loss and fever. Symptoms vary in severity and duration; some patients suffer from frequent prolonged attacks, and others have fewer recurrences. The disease usually starts in the adolescent or young adult years. In ulcerative colitis, the inner lining of the colon is inflamed. People with Crohn's disease have similar inflammation, but it extends deeper into the intestinal wall and can also involve the small and large intestines.

Researchers from Johns Hopkins University, University of Chicago, University of Pittsburgh and the Cleveland Clinic participated in both studies, and researchers from University of Toronto and New York University participated in the NFKB1 study. These studies were funded by the National Institutes of Health, the Crohn's and Colitis Foundation of America, the Meyerhoff IBD Center, the Stewart W. Bainum family, the Reva and David Logan Foundation, the Scaife Family Foundation, the Israeli Society of Gastroenterology, Toyobo Biotechnology Foundation, the Crohn's and Colitis Foundation of Canada, the Canadian Association of Gastroenterology, the Canadian Institutes of Health Research, , and the Gastrointestinal Research Foundation.

Functional Annotation of a Novel NFKB1
'"/>

Contact: Trent Stockton
tstockt1@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
19-Dec-2003


Page: 1 2 3 4

Related medicine news :

1. Alzheimers disease - recent discoveries pave the way toward new treatments
2. California chemist wins national award for drug discoveries
3. NIH-funded UCSD rheumatic diseases center to facilitate collaboration, speed discoveries
4. Virginia Tech students discoveries can help prevent water-borne diseases
5. Japanese chemist wins U.S. award for molecular discoveries
6. Stony Brook chemist wins national award for drug discoveries
7. 7,000 Pharmaceutical scientists to share latest drug developments and discoveries
8. Protein that helps skin cancer spread identified by Stanford researchers
9. Treating depression helps slow physical decline in older adults, study shows
10. Laughter helps blood vessels function better
11. Chemists synthesize molecule that helps body battle cancers, malaria

Post Your Comments:
(Date:5/24/2015)... 2015 EnviroLeather™ by LDI, a ... – a classic, rugged leather grain with enhanced ... stains, including ink, to be easily removed. The ... for corporate, healthcare, hospitality and education environments. , ... goal of developing products that are more sustainable, ...
(Date:5/24/2015)... May 24, 2015 ... CEO - The students were ... at the fourth annual A Day ... at Geneva National in Lake Geneva. ...     -Badger High School,         Jonathan Alfonso,         Bridget ...
(Date:5/23/2015)... With the implementation of the Affordable ... increasingly difficult to provide their employees with a viable ... insurance for employees stand to face strict penalties. Never ... part of a business’s success or failure. In an ... USA Doctors has created a varying level of less ...
(Date:5/23/2015)... 23, 2015 Javon Bea Mercy ... Sports Medicine and Rehabilitation Center, 557 N. Washington St., ... June 1-July 20, 5:30-6:30 pm. , The 8-week clinic ... Laurie Finke, RN, BSN, who will offer training that ... nutrition, running mechanics and show selection and weekly training ...
(Date:5/22/2015)... May 22, 2015 The American College ... events in June. They will hold a webinar on ... a two-day class on Classical Chinese Medicine. , Webinar ... Dr. Steve Given, the Dean of Clinical Education, will ... new First Professional Doctorate program. ACTCM is currently developing ...
Breaking Medicine News(10 mins):Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 3Health News:ACTCM Announces Upcoming June Events 2
(Date:5/22/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/3rthk2/latest ) ... Regulations on Pharmaceutical International Multi-Center Clinical Trials in ... This is first time in history, Chinese pharmaceutical ... clinical trials of drugs in China ... on March 1, 2015. The guidance provides an ...
(Date:5/22/2015)... China , May 22, 2015  China Nepstar ... "Company"), a leading retail drugstore chain in ... operated stores, today announced the resignation of Mr. ... for personal reasons, effective immediately. Ms. Rebecca Yingnan ... by the Company,s board of directors, effective immediately. Meanwhile, ...
(Date:5/21/2015)... DUBLIN , May 21, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/5x7nlz/arthroscopy ) has announced the addition of ... report to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... to analyze and size the world market ... players and identifies trends impacting the market ...
Breaking Medicine Technology:2015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 3Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3
Cached News: