HOME >> MEDICINE >> NEWS
A site for sore eyes: New target for allergies found under the eyelid

Scientists have found a protein in the eye which plays a critical role in how an allergic response develops over a 24-hour period. The University College London (UCL) team hope their discovery will pave the way for new treatments for allergic diseases such as asthma, eczema and hay fever.

In a study published today in the online edition of the Journal of Clinical Investigation, Professor Santa Jeremy Ono and colleagues from UCL's Institute of Ophthalmology and Moorfields Eye Hospital found that the macrophage inflammatory protein-1a, known as MIP-1a and located in the eye, plays a crucial role in the early stages of an allergic response. Their findings suggest that drugs that block the binding of MIP-1a to its receptors could help in the treatment of ocular allergy and other allergic diseases.

Allergies affect over one third of individuals in the Western world, with 17 million people in the UK currently suffering from asthma, conjunctivitis, eczema or hay fever.

Allergic responses develop in two phases. The first phase involves an immediate hypersensitivity reaction within one hour of exposure to an allergen, where mast cells (key cells responsible for causing allergies) release histamine and other molecules such as chemokines. MIP-1a is one such chemokine.

The second phase, which occurs 12 to 24 hours after exposure, involves the recruitment of inflammatory cells to the site of inflammation. While the role of chemokines in the second phase is well characterized, little is known about how chemokines contribute to the first phase of an allergic disease.

Ono and colleagues discovered that within the clear membrane that coats the inner surface of the eyelid and outer surface of the eye, known as the conjunctiva, MIP-1a was essential in the initial stages of development of an allergic response.

MIP-1a was also necessary for the second phase of the disease, which is associated with chronic allergy. It is likely t
'"/>

Contact: Jenny Gimpel
j.gimpel@ucl.ac.uk
44-207-679-9739
University College London
13-Jan-2005


Page: 1 2

Related medicine news :

1. Kaleidescope eyes: the secrets of a novel gift
2. NHS target driven culture is failing patients
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. NHS stop-smoking services are insufficient to deliver national smoking targets
5. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
6. Potential drug target for treating cocaine abuse found
7. NHS Trusts meeting government target on stroke units in name only
8. Inflammatory cells highly promising target in NF 1
9. T cells target HIV in a relationship on the rebound
10. Residual tumor cells are a barrier to targeted cancer therapeutics
11. Genetically targeted therapies create opportunities to do business in new ways

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
(Date:9/18/2017)... 2017 EpiVax, Inc. ("EpiVax") a ... immune engineering, today announced a new NIH-funded ... ... and presents a challenge for traditional flu ... be effective. Using state-of-the-art bioinformatics and molecular modeling methods, ...
Breaking Medicine Technology:
Cached News: