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A site for sore eyes: New target for allergies found under the eyelid

hat MIP-1a or similar molecules are also essential for the development of other allergies such as asthma, dermatitis or anaphylaxis, a body-wide allergy that left untreated can result in death.

The UCL study suggests that drugs that block the binding of MIP-1a to its receptors CCR1 or CCR5 may have therapeutic value in the treatment of ocular allergy and possibly other allergic diseases.

Professor Ono says: "Current treatments for severe eye allergy are either ineffective or have associated side effects, such as glaucoma and cataract formation, so our study will be of interest to allergists and ophthalmologists. Many current allergy treatments target symptoms rather than the cause of the disease, meaning this discovery could constitute a new target for the treatment of allergic diseases.

"We are currently carrying out studies to test the efficacy of existing drugs that block MIP-1a and similar molecules in the therapy of allergic diseases. Clinical trials are anticipated shortly and if they prove effective, these studies may lead to new therapies within the next 5 to 7 years."


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Contact: Jenny Gimpel
j.gimpel@ucl.ac.uk
44-207-679-9739
University College London
13-Jan-2005


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