Alexandria, VA -- The American Association of Pharmaceutical Scientists' (AAPS) newest exclusively online journal, AAPS PharmSciTech, http://www.pharmscitech.com, today published its premier issue. A summary of each original research article is provided below.
Orthogonal HPLC Methods For Quantitating Related Substances and Degradation Products of Pramlintide By Richard A. Kenley, Wade Demond, James L. Italien, David Lokensgard, and G. Weilersbacher.
Pramlintide is a 37-amino acid peptide under development for diabetes therapy. This investigation describes analytical test methods for assuring the purity of the drug. These methods may have general application for analysis of complex peptides intended for therapeutic use.
Sustained Activity and Release of Leuprolide Acetate from an In Situ Polymeric Implant By Harish B. Ravivarapu, Katie L. Moyer, and Richard L. Dunn This article describes the preclinical development of an injectable and in situ forming polymeric implant system for effective delivery and activity of leuprolide acetate over a period of 90 days in the treatment of prostate cancer.
The Stabilization and Release of Hirudin from Liposomes or Lipid-Assemblies Coated with Hydrophobically Modified Dextran By Russell J. Mumper and Allan S. Hoffman Hirudin is a peptide used to prevent deep-vein thrombosis following knee and hip replacement surgery. Palmitoyl dextran-coated liposomes were found to stabilize hirudin, thereby enhancing the peptide's ability to inhibit thrombin.
Dynamic Changes in Size Distribution of Emulsion Droplets During Ethyl Acetate-Based Microencapsulation Process
By Yogita Bahl and Hongkee Sah
This study focuses on the dynamic process of the breakup and formation of emulsion droplets during an ethyl acetate-based emulsion microencapsulation process. The results reported provide invaluable insight into the effect of the onset of ethyl ace
Contact: Debbie Mierke
American Association of Pharmaceutical Scientists