AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

l-fed rabbits, an accepted and well established experimental model that has been used in the development of current cholesterol-lowering therapies, including the statins. The results showed that CETP-vaccinated rabbits exhibited significantly reduced CETP activity and changes in plasma lipoproteins. Moreover, CETP-vaccinated rabbits had higher concentrations of HDL cholesterol in their blood, and had significantly smaller areas of fatty streak lesions in their aortas than were exhibited by untreated control animals.

AVANT believes that inhibiting CETP has great potential to be a safe and effective strategy for preventing coronary artery disease. AVANT cites the existence of a well-studied human population in Japan which congenitally lacks functional CETP. Individuals with this genetic mutation have been observed to have high HDL levels and a low incidence of atherosclerosis, and to have otherwise normal health. AVANT hopes to show similar effects in normal individuals through vaccination.

Dr. Ryan said, "Currently there is no effective therapy for increasing blood HDL levels: diet and moderate exercise are ineffective, statins produce only a modest 5-7% increase in HDL cholesterol, and niacin has side effects that limit its use. In addition, patient compliance with cholesterol lowering drugs has been low, leading to their reduced usefulness. Thus we believe a vaccine approach to raising HDL, by which patients might receive treatment two to three times yearly, could offer significant benefits for reducing the risks of atherosclerosis and coronary artery disease. In addition, such a vaccine might expand the market for cholesterol-lowering therapies to people at somewhat lower health risk, for whom cholesterol-lowering drugs are not presently employed."

Atherosclerosis is a progressive condition leading to arterial blockage and reduced blood flow by fatty deposits called plaque on blood vessel walls. This condition significantly increases the ris

Contact: Joan Kureczka
Kureczka/Martin Associates

Page: 1 2 3

Related medicine news :

1. Atherosclerosis linked to depression in older persons
2. Atherosclerosis more common, progresses quicker in HIV patients
3. Successful Atherosclerosis Treatment Program
4. Vaccine against childhood pneumonia shows promise
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Vaccine preparedness, or not
7. Oct. 14 Web cast: Reporters Workshop -- Covering Vaccines & Immunizations
8. Vaccine reduces racial disparity in incidence of childhood pneumonia and meningitis
9. Vaccine nips breast cancer in the bud
10. Vaccine shows promise for kidney cancer
11. Vaccine development against influenza A (h5n1) virus should be made a priority

Post Your Comments:

(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on ... Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ability ... fumigation is not a common occurrence, but a necessary one in the event that lice ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room ... Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
Breaking Medicine Technology:
Cached News: