HOME >> MEDICINE >> NEWS
AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

l-fed rabbits, an accepted and well established experimental model that has been used in the development of current cholesterol-lowering therapies, including the statins. The results showed that CETP-vaccinated rabbits exhibited significantly reduced CETP activity and changes in plasma lipoproteins. Moreover, CETP-vaccinated rabbits had higher concentrations of HDL cholesterol in their blood, and had significantly smaller areas of fatty streak lesions in their aortas than were exhibited by untreated control animals.

AVANT believes that inhibiting CETP has great potential to be a safe and effective strategy for preventing coronary artery disease. AVANT cites the existence of a well-studied human population in Japan which congenitally lacks functional CETP. Individuals with this genetic mutation have been observed to have high HDL levels and a low incidence of atherosclerosis, and to have otherwise normal health. AVANT hopes to show similar effects in normal individuals through vaccination.

Dr. Ryan said, "Currently there is no effective therapy for increasing blood HDL levels: diet and moderate exercise are ineffective, statins produce only a modest 5-7% increase in HDL cholesterol, and niacin has side effects that limit its use. In addition, patient compliance with cholesterol lowering drugs has been low, leading to their reduced usefulness. Thus we believe a vaccine approach to raising HDL, by which patients might receive treatment two to three times yearly, could offer significant benefits for reducing the risks of atherosclerosis and coronary artery disease. In addition, such a vaccine might expand the market for cholesterol-lowering therapies to people at somewhat lower health risk, for whom cholesterol-lowering drugs are not presently employed."

Atherosclerosis is a progressive condition leading to arterial blockage and reduced blood flow by fatty deposits called plaque on blood vessel walls. This condition significantly increases the ris
'"/>

Contact: Joan Kureczka
JKureczka@aol.com
415-821-2413
Kureczka/Martin Associates
19-Apr-1999


Page: 1 2 3

Related medicine news :

1. Atherosclerosis linked to depression in older persons
2. Atherosclerosis more common, progresses quicker in HIV patients
3. Successful Atherosclerosis Treatment Program
4. Vaccine against childhood pneumonia shows promise
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Vaccine preparedness, or not
7. Oct. 14 Web cast: Reporters Workshop -- Covering Vaccines & Immunizations
8. Vaccine reduces racial disparity in incidence of childhood pneumonia and meningitis
9. Vaccine nips breast cancer in the bud
10. Vaccine shows promise for kidney cancer
11. Vaccine development against influenza A (h5n1) virus should be made a priority

Post Your Comments:
(Date:8/27/2014)... August 27, 2014 Shawna's new book, ... is about Seed Digging, which a brand-new technique she ... models, yet works to bring permanent healing quickly. , ... and mental health disorders cured on a daily basis. ... own minds and find incredible inner peace with only ...
(Date:8/27/2014)... iFitDress.com, a professional company of women’s dresses and related ... bridal gowns . To top it all off, all ... percent off) when buying the company’s new items. ... with these new items. All its online sales representatives ... can gain an enjoyable shopping experience on its website. ...
(Date:8/27/2014)... Seventy-three members of the founding class ... beginning of their careers as healthcare professionals at a ... entering a four-year PharmD program traditionally receive white coats?a ... into the profession as colleagues dedicated to patient care. ... Garrison Theater in Claremont, Calif., KGI President Sheldon Schuster ...
(Date:8/27/2014)... 27, 2014 Ticket Down is ... at Levi’s Stadium in Santa Clara. Levi’s Stadium ... California just opened in July and will host their first ... on Chile. These are two of the best teams that ... Cup and will look to continue their successes from the ...
(Date:8/27/2014)... TN (PRWEB) August 27, 2014 ... Shofner Vision Center see multitudes of patients suffering from ... LASIK and Cataract vision correction surgery . Recently, ... requesting glaucoma information during an eye exam and also ... debunks the top five myths about glaucoma. , 1)    Myth: ...
Breaking Medicine News(10 mins):Health News:Shawna Burns, Counselor, Releases Debut Book, "Seed Digging," to Improve Lives of Children and Adults with Addictions and Mental Health Disorders 2Health News:Promotion For Romantic Bridal Gowns Launched By Professional Company iFitDress.com 2Health News:Founding Class of the KGI School of Pharmacy Formally Welcomed into the Profession at a Traditional White Coat Ceremony 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 3Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 2Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 3Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 4
(Date:8/27/2014)... Varian Medical Systems (NYSE: VAR) today broke ground on ... Lake City manufacturing facility and allow for the ... to ultimately create 1,000 new full time jobs ... " Utah is home to hardworking ... can be credited with Varian,s success in the manufacturing of ...
(Date:8/27/2014)... DALLAS , August 27, 2014 ... "Dental Equipment Market By Products (Dental Radiology, CAD/CAM, Dental Chairs, ... 2019" published by MarketsandMarkets, the global Dental Equipment Market ... from $5,416.3 million in 2014, growing at a ... Browse 95 market data tables and 61 ...
(Date:8/27/2014)... 27, 2014 ResearchMoz presents this ...  Laparoscopes Market Outlook to 2020. New report, "United States ... on the United States Laparoscopes market . The ... (in units) and average prices (in US dollars) within ... Flexible Tip Video Laparoscopes), Robotic Surgical Systems and Rigid ...
Breaking Medicine Technology:Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 4Dental Equipment Market Worth $7,138.9 Million by 2019 2Dental Equipment Market Worth $7,138.9 Million by 2019 3United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 3United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 4United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 5
Cached News: