HOME >> MEDICINE >> NEWS
AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

l-fed rabbits, an accepted and well established experimental model that has been used in the development of current cholesterol-lowering therapies, including the statins. The results showed that CETP-vaccinated rabbits exhibited significantly reduced CETP activity and changes in plasma lipoproteins. Moreover, CETP-vaccinated rabbits had higher concentrations of HDL cholesterol in their blood, and had significantly smaller areas of fatty streak lesions in their aortas than were exhibited by untreated control animals.

AVANT believes that inhibiting CETP has great potential to be a safe and effective strategy for preventing coronary artery disease. AVANT cites the existence of a well-studied human population in Japan which congenitally lacks functional CETP. Individuals with this genetic mutation have been observed to have high HDL levels and a low incidence of atherosclerosis, and to have otherwise normal health. AVANT hopes to show similar effects in normal individuals through vaccination.

Dr. Ryan said, "Currently there is no effective therapy for increasing blood HDL levels: diet and moderate exercise are ineffective, statins produce only a modest 5-7% increase in HDL cholesterol, and niacin has side effects that limit its use. In addition, patient compliance with cholesterol lowering drugs has been low, leading to their reduced usefulness. Thus we believe a vaccine approach to raising HDL, by which patients might receive treatment two to three times yearly, could offer significant benefits for reducing the risks of atherosclerosis and coronary artery disease. In addition, such a vaccine might expand the market for cholesterol-lowering therapies to people at somewhat lower health risk, for whom cholesterol-lowering drugs are not presently employed."

Atherosclerosis is a progressive condition leading to arterial blockage and reduced blood flow by fatty deposits called plaque on blood vessel walls. This condition significantly increases the ris
'"/>

Contact: Joan Kureczka
JKureczka@aol.com
415-821-2413
Kureczka/Martin Associates
19-Apr-1999


Page: 1 2 3

Related medicine news :

1. Atherosclerosis linked to depression in older persons
2. Atherosclerosis more common, progresses quicker in HIV patients
3. Successful Atherosclerosis Treatment Program
4. Vaccine against childhood pneumonia shows promise
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Vaccine preparedness, or not
7. Oct. 14 Web cast: Reporters Workshop -- Covering Vaccines & Immunizations
8. Vaccine reduces racial disparity in incidence of childhood pneumonia and meningitis
9. Vaccine nips breast cancer in the bud
10. Vaccine shows promise for kidney cancer
11. Vaccine development against influenza A (h5n1) virus should be made a priority

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/13/2017)... Boulder, CO (PRWEB) , ... January 13, 2017 , ... ... Congress, a growing alliance of deans of colleges and schools of education across the ... public schools. , In a Declaration of Principles released today, 175 deans sounded the ...
(Date:1/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has published a new ... way to peace, health and eternal joy. Yisrayl says he has been accused of being ... that false accusations and persecution are nothing new in his world and says it has ...
(Date:1/13/2017)... , ... January 13, 2017 , ... One way to ... nationals can qualify if they can show their work is in the national interest. ... self-petition rather than having to be sponsored by an employer; and 2) the submission ...
(Date:1/13/2017)... ... 13, 2017 , ... U.S. News & World Report highly ... its 2017 Best Online Graduate Nursing Programs list released Jan. 10. The School ... graduate degree programs include a family nurse practitioner doctor of nursing practice (DNP), ...
(Date:1/13/2017)... ... 2017 , ... PrideStaff, a national, franchised staffing organization ... franchise by Entrepreneur. , The 38th annual Franchise 500® ranking was determined using ... success. All entrants were judged by financial strength and stability, growth rate and ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... Jan 13, 2017 Research and Markets has ... and Analysis" report to their offering. ... Cystic fibrosis (CF) is a progressive ... faulty cystic fibroses transmembrane conductance regulator (CFTR) gene from both parents. ... epithelial cells, and result in the buildup of a thick and ...
(Date:1/13/2017)... -- ... Research and Markets has announced the addition of the ... offering. The disease is divided into two categories ... melanoma, which can be treated with surgery, and advanced melanoma, which ... therapy aiming to prevent disease re-occurrence, and advanced therapies aiming to ...
(Date:1/12/2017)... Imaging, Inc., leading designer and manufacturer of the innovative ... proud to announce FDA 510(k) clearance of the G-Arm ... of the G-Arm with major improvements including axial tilt ... be launching this sooner than our original intended date," ... Marketing at Whale. "We feel that getting the B6 ...
Breaking Medicine Technology:
Cached News: