AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

l-fed rabbits, an accepted and well established experimental model that has been used in the development of current cholesterol-lowering therapies, including the statins. The results showed that CETP-vaccinated rabbits exhibited significantly reduced CETP activity and changes in plasma lipoproteins. Moreover, CETP-vaccinated rabbits had higher concentrations of HDL cholesterol in their blood, and had significantly smaller areas of fatty streak lesions in their aortas than were exhibited by untreated control animals.

AVANT believes that inhibiting CETP has great potential to be a safe and effective strategy for preventing coronary artery disease. AVANT cites the existence of a well-studied human population in Japan which congenitally lacks functional CETP. Individuals with this genetic mutation have been observed to have high HDL levels and a low incidence of atherosclerosis, and to have otherwise normal health. AVANT hopes to show similar effects in normal individuals through vaccination.

Dr. Ryan said, "Currently there is no effective therapy for increasing blood HDL levels: diet and moderate exercise are ineffective, statins produce only a modest 5-7% increase in HDL cholesterol, and niacin has side effects that limit its use. In addition, patient compliance with cholesterol lowering drugs has been low, leading to their reduced usefulness. Thus we believe a vaccine approach to raising HDL, by which patients might receive treatment two to three times yearly, could offer significant benefits for reducing the risks of atherosclerosis and coronary artery disease. In addition, such a vaccine might expand the market for cholesterol-lowering therapies to people at somewhat lower health risk, for whom cholesterol-lowering drugs are not presently employed."

Atherosclerosis is a progressive condition leading to arterial blockage and reduced blood flow by fatty deposits called plaque on blood vessel walls. This condition significantly increases the ris

Contact: Joan Kureczka
Kureczka/Martin Associates

Page: 1 2 3

Related medicine news :

1. Atherosclerosis linked to depression in older persons
2. Atherosclerosis more common, progresses quicker in HIV patients
3. Successful Atherosclerosis Treatment Program
4. Vaccine against childhood pneumonia shows promise
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Vaccine preparedness, or not
7. Oct. 14 Web cast: Reporters Workshop -- Covering Vaccines & Immunizations
8. Vaccine reduces racial disparity in incidence of childhood pneumonia and meningitis
9. Vaccine nips breast cancer in the bud
10. Vaccine shows promise for kidney cancer
11. Vaccine development against influenza A (h5n1) virus should be made a priority

Post Your Comments:

(Date:11/25/2015)... Neb. (PRWEB) , ... November 25, 2015 , ... ... staffing companies, has been recognized once again for its stellar workplace culture with ... to Work.” , Medical Solutions’ Cincinnati office was named a finalist ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... For the ... companies’ “ Two Organizations, One Beat ” campaign. The partnership between the two groups ... to aid in MAP International’s cause. , MAP International was founded in 1954 and ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... for physicians and athletic programs, launches new Wimbledon Athletics Facebook page ... testing young athletes for unsuspected cardiac abnormalities. About 2,000 people under the age ...
(Date:11/25/2015)... Calif. (PRWEB) , ... November 25, 2015 , ... Beddit® ... and Beddit Classic sleep tracking systems. The new app features a more intuitive SleepScore™ ... and understand how well you slept. The SleepScore is created by a proprietary algorithm. ...
(Date:11/25/2015)... ST. LOUIS, Missouri (PRWEB) , ... November 25, ... ... with Project HEAL, will provide scholarships for people struggling with eating disorders as ... Proceeds from the second annual event, held at Fox Run Golf Club ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "2016 Future ... Drugs of Abuse Testing Market: Supplier Shares, ... report to their offering. --> ... of the "2016 Future Horizons and ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Therapeutic Drug Monitoring (TDM) Market: Supplier ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
(Date:11/26/2015)... , Nov. 26, 2015 Research ... addition of the "2016 Future Horizons and ... (TDM) Market: Supplier Shares, Country Segment Forecasts, Competitive ... --> --> ... analysis of the Italian therapeutic drug monitoring market, ...
Breaking Medicine Technology:
Cached News: