HOME >> MEDICINE >> NEWS
AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

l-fed rabbits, an accepted and well established experimental model that has been used in the development of current cholesterol-lowering therapies, including the statins. The results showed that CETP-vaccinated rabbits exhibited significantly reduced CETP activity and changes in plasma lipoproteins. Moreover, CETP-vaccinated rabbits had higher concentrations of HDL cholesterol in their blood, and had significantly smaller areas of fatty streak lesions in their aortas than were exhibited by untreated control animals.

AVANT believes that inhibiting CETP has great potential to be a safe and effective strategy for preventing coronary artery disease. AVANT cites the existence of a well-studied human population in Japan which congenitally lacks functional CETP. Individuals with this genetic mutation have been observed to have high HDL levels and a low incidence of atherosclerosis, and to have otherwise normal health. AVANT hopes to show similar effects in normal individuals through vaccination.

Dr. Ryan said, "Currently there is no effective therapy for increasing blood HDL levels: diet and moderate exercise are ineffective, statins produce only a modest 5-7% increase in HDL cholesterol, and niacin has side effects that limit its use. In addition, patient compliance with cholesterol lowering drugs has been low, leading to their reduced usefulness. Thus we believe a vaccine approach to raising HDL, by which patients might receive treatment two to three times yearly, could offer significant benefits for reducing the risks of atherosclerosis and coronary artery disease. In addition, such a vaccine might expand the market for cholesterol-lowering therapies to people at somewhat lower health risk, for whom cholesterol-lowering drugs are not presently employed."

Atherosclerosis is a progressive condition leading to arterial blockage and reduced blood flow by fatty deposits called plaque on blood vessel walls. This condition significantly increases the ris
'"/>

Contact: Joan Kureczka
JKureczka@aol.com
415-821-2413
Kureczka/Martin Associates
19-Apr-1999


Page: 1 2 3

Related medicine news :

1. Atherosclerosis linked to depression in older persons
2. Atherosclerosis more common, progresses quicker in HIV patients
3. Successful Atherosclerosis Treatment Program
4. Vaccine against childhood pneumonia shows promise
5. Vaccine may complement conventional treatment for chronic leukaemia
6. Vaccine preparedness, or not
7. Oct. 14 Web cast: Reporters Workshop -- Covering Vaccines & Immunizations
8. Vaccine reduces racial disparity in incidence of childhood pneumonia and meningitis
9. Vaccine nips breast cancer in the bud
10. Vaccine shows promise for kidney cancer
11. Vaccine development against influenza A (h5n1) virus should be made a priority

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... Beverly Hills, CA (PRWEB) , ... April 29, 2016 , ... ... distributor of devices and products for the head and neck/ear, nose and throat specialty, ... Safety Device , The KOTLER NASAL AIRWAY™ is a newly patented safety ...
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, the market ... funding led by Eastside Partners, with participation from existing investor Martin Ventures. ... and accelerate its technology and product roadmap. , “Jvion is experiencing ...
(Date:4/29/2016)... ... ... Regenerative Medicine Solutions (RMS) scored 94.8124 out of 100 on ... place for Tampa’s Best Places to Work. They were ranked in the Big Category, ... for our team,” says RMS Human Resources Manager Irene Miller. “We work hard to ...
(Date:4/29/2016)... ... 29, 2016 , ... The infertility specialists at HRC Fertility/Orange County (HRC/OC) -- ... A. Potter -- are proud of the recent release of their 2014 in vitro ... SART published the latest verified data for 375 U.S. member clinics. *Preliminary data ...
(Date:4/29/2016)... Westlake Village, CA (PRWEB) , ... April 29, ... ... Greater Philadelphia Pet Expo to promote their animal line of probiotics, Petbiotics ... to see the large turnout of animal rescue groups networking for their non-profit ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... Review, H1 2016" is a report that provides ... helps strengthen R&D pipelines by identifying new targets ... Company Profiles discussed in this H1 ... Farmaceutiche Riunite Srl, AbbVie Inc., Abiogen Pharma S.p.A., ...
(Date:4/27/2016)...   , Total Sales Grow ... Clinical sales grow 16% year-over-year  , ... MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser endomicroscopy ... ended March 31, 2016 and provided an update on ... First Quarter 2016 Revenue Results by Category  ...
(Date:4/27/2016)... 27, 2016 Tie-up with Government ... to save newborns   Fortis La ... newborns in collaboration with Breast Milk Foundation (BMF), a non-profit ... Human Milk Bank, ,Amaara, in Delhi-NCR today. This non-profit centre ... for infants and should be available to babies deprived of ...
Breaking Medicine Technology:
Cached News: