HOME >> MEDICINE >> NEWS
Actonel helped preserve bone quality at five years, new data show

MINNEAPOLIS (September 22, 2003) Actonel (risedronate sodium tablets) helped preserve important aspects of bone quality at five years in postmenopausal women with osteoporosis, according to new research presented at the 25th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR).

"Studies suggest that bone quality may be an important contributor to bone strength and fracture resistance. These new data provide value in learning how therapies such as risedronate affect bone quality," said principal investigator Eleftherios P. Paschalis, PhD, Ludwig Boltzmann Institute for Osteology, Vienna. "However, additional studies are necessary to fully understand how the different aspects of bone quality relate to fracture risk."

One aspect of bone quality is the integrity of the material components of bone. Bone is a living tissue composed of calcium-based mineral crystals that are embedded in a network of protein fibers, called collagen. In osteoporotic bone, the calcium-based mineral crystals enlarge and the integrity of the collagen deteriorates compared to what is found in normal bone. Actonel, as shown in study biopsies, maintained the size of the calcium crystals and the integrity of the collagen structure over five years of treatment. Actonel is the only osteoporosis therapy for which these aspects of bone quality have been evaluated in bone biopsies taken from the same patients before and after five years of treatment.

About the Study
The study analyzed paired iliac crest biopsies from eight postmenopausal women with osteoporosis who received Actonel (5mg/day) over a 5-year period. The biopsies were analyzed with a novel imaging technique called Fourier Transform Infrared Spectroscopic Imaging (FTIRI), which provides microscopic information on the size of the calcium-based mineral crystals (crystallinity) and the structure of the collagen (collagen cross-link ratio, pyr/deH-DHLNL).

Biopsies
'"/>


22-Sep-2003


Page: 1 2 3 4 5

Related medicine news :

1. Actonel reduced nonveterbral fracture as early as 6 months
2. New analysis shows early intervention with Actonel reduces first vertebral fracture risk
3. FDA approves Actonel for once-a-week use
4. Study shows Actonel reduces vertebral fracture risk 70 percent in patients on chronic steroid therapy
5. Has cricket helped to unite South Asia?
6. Treatment helped reduce dose of inhaled corticosteroids while maintaining asthma control
7. Media focus on endostatin helped -- not hurt --
8. Burnout patients helped by comparisons with colleagues
9. Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects
10. Doctors transplant ovary to womans arm to preserve fertility
11. Physical activity in later years helps women preserve functional abilities

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Actonel helped preserve bone quality five years new data show

(Date:4/17/2014)... vaccine brands for children may not be the most ... factors when choosing vaccines, driving the market toward what ... new study by University of Illinois researchers. , "The ... numerous factors," says Sheldon H. Jacobson, a co-author of ... of mathematics at the U. of I. "In an ...
(Date:4/17/2014)... Diego School of Medicine report that older women, plucky ... loss are more likely to be compassionate toward strangers ... in this month,s issue of the International Journal ... associated with better health and well-being as we age, ... the outcomes of individuals whose deficits in compassion put ...
(Date:4/17/2014)... Pediatrician-in-Chief Jon McCullers, MD, was recently invited to ... Nature Reviews Microbiology , one of the ... world-renowned infectious disease specialist, and chair of the ... Health Science Center, analyzed the epidemiology and microbiology ... pandemics, as well as more recent 2009 novel ...
(Date:4/17/2014)... who treat patients with a severe and progressive ... agonizing treatment decision. , The drug sirolimus can ... shortness of breath. But some patients eventually may ... fatal complications following transplantation. , "It,s a terrible ... of Loyola University Medical Center,s LAM Clinic and ...
(Date:4/17/2014)... IL, April 17, 2014-- Colic affects about one in ... for numerous pediatric visits during the first several months ... colic symptoms was showing promise; however, the April 1, ... (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics and ... L reuteri for infant colic did ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:The ilk of human kindness 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... - India Drug Forecast and Market Analysis ... PharmaPoint: Atopic Dermatitis - India ...
(Date:1/15/2014)... Jan. 15, 2014  A novel wearable injector slightly larger than ... for patients to self-inject prescription drugs in the large doses ... blood diseases, autoimmune deficiencies, and genetic disorders.  ... $220B by 2018, according to analysts.   Many of these drugs ...
(Date:1/14/2014)... Healthcare Services, Inc. ("DHS"), a portfolio company of GMH Ventures ... Equipment, Inc. ("Progressive") of Clarion, PA ... not disclosed. Progressive is a full service ... sleep, mobility, and respiratory products to customers in the western ...
Breaking Medicine Technology:PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3
Cached News: