HOME >> MEDICINE >> NEWS
Adding radiation therapy to chemotherapy improves survival in patients with high-risk breast cancer

For patients with high-risk breast cancer treated with radical mastectomy and adjuvant chemotherapy, the addition of radiation therapy leads to better survival outcomes with few long-term toxic effects, according to a 20-year follow-up of a randomized trial, which appears in the January 19 issue of the Journal of the National Cancer Institute.

The British Columbia randomized radiation therapy trial was designed to determine the effect on survival of the addition of locoregional radiation therapy (radiation to the lymph nodes and chest wall) to a course of chemotherapy after radical mastectomy in premenopausal women with lymph nodepositive breast cancer. Between 1979 and 1986, 318 patients were randomly assigned to receive no radiation therapy or to receive radiation. A 15-year follow-up found that radiation therapy was associated with improved breast cancer survival but not with overall survival.

In this 20-year follow-up of the British Columbia trial, Joseph Ragaz, M.D., of McGill University Health Center in Montreal, and colleagues found that the chemotherapy and radiation regimen, compared with chemotherapy alone, was associated with improvement in all end points analyzed. This included a 32% reduction in breast cancer mortality and a 27% reduction in overall mortality compared with chemotherapy alone. In addition, long-term toxic effects, including cardiac deaths, were acceptable for both groups of patients.

"Our results, and those from other groups, confirm that in situations where residual disease remains, adjuvant chemotherapy alone in high-risk breast cancer patients is suboptimal and that the addition of locoregional radiation therapy is important to achieve the highest cure rate," the authors write.

In an editorial, Timothy Whelan, B.M., B.Ch., and Mark Levine, M.D., of the Juravinski Cancer Centre in Hamilton, Ontario, discuss the use of locoregional radiation therapy in breast cancer patients and note that fewer cli
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
18-Jan-2005


Page: 1 2

Related medicine news :

1. Adding menthol to topical creams for osteoarthritis provides significant pain relief
2. Adding Progestins May Negate Heart Protection From Estrogen Replacement Therapy
3. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
4. Combining PET and CT scans leads to more accurate radiation therapy for lung cancer patients
5. NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure
6. Florida Tech scientist wins patent for device to deliver X-ray irradiation
7. More precise radiation therapy lets prostate cancer patients avoid erectile dysfunction
8. Combining hormones with external, internal radiation helps high risk prostate cancer patients
9. Timing appears essential to combining antiangiogenesis and radiation therapy
10. Can the standard course of radiation therapy following lumpectomy be shortened?
11. Understanding how prostaglandin prevents gut injury during radiation therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2020)... , ... February 26, 2020 , ... ... platform, today announced the launch of its new HealthBus Worklflows solution, which will ... the crafting and deploying of client-specific health data exchange workflows to scenarios in ...
(Date:2/21/2020)... , ... February 21, 2020 , ... Dr. Stong, a ... advocate for giving back. He has been a long-time volunteer with Healing the ... of this particular HTC trip is to provide cleft lip and palate procedures to ...
(Date:2/21/2020)... ... February 21, 2020 , ... Used for ... continues to garner traction as a viable replacement for invasive cosmetic surgery, such ... is predicted to remain the market leader for the expected robust growth of ...
(Date:2/21/2020)... ... February 21, 2020 , ... ... lifestyle solutions, has announced its third and final round of Canada finalists for ... finalists are John Birr of Markdale, Ontario; Taiya Farrell of Winnipeg, Manitoba; Véronique ...
(Date:2/20/2020)... Pa. (PRWEB) , ... February 20, 2020 , ... Millennial ... Dermatology Surgery & Laser Center in Milford, Penn requesting treatments to achieve “ Rich ... And it doesn’t look like it is slowing down into 2020. It’s a look ...
Breaking Medicine News(10 mins):
(Date:2/20/2020)... ... February 20, 2020 , ... NJ Top Docs practice, The Rubino ... in Warren, NJ on Thursday, January 16 at 12PM. The Rubino OB/GYN Group ... the ribbon-cutting ceremony. Members of the public and media were also in attendance. , ...
(Date:2/20/2020)... ... February 20, 2020 , ... ... Scottsdale Road, in Arizona, will be a timely and relevant 2-day program providing ... in the management of chronic pain. , In 2020, paper prescriptions for certain ...
(Date:2/19/2020)... , ... February 19, 2020 , ... ... readmission rate and skilled nursing facility rehospitalization rate are the lowest in the ... 4.7 percent, a 29 percent drop year over year. GHC’s skilled nursing facility ...
Breaking Medicine Technology:
Cached News: