Advance reported in search for skin cancer treatment

In a search for skin cancer treatments, chemists at the University of Notre Dame have constructed a computer model of the chemical structure of an enzyme that many organisms use to repair DNA damaged by ultraviolet light. Their findings are reported in the June 9 issue of the Journal of the American Chemical Society and are now on the journal's website at http://pubs.acs.org/journals/jacsat/index.html.

According to Olaf Wiest, assistant professor of chemistry and biochemistry and principal investigator, the ultimate goal of the research is to produce an artificial enzyme for human use that could repair DNA damaged by ultraviolet light in humans. Such damage leads to certain types of skin cancer, which have reached almost endemic proportions. Skin cancer is now the most common form of cancer in the United States, with an estimated 1.4 million cases diagnosed annually. According to Wiest, the number of skin cancer patients has risen steadily over the past 20 years.

The computer model provides atomic details of the binding interactions of damaged DNA and DNA photolyase, the repair enzyme of the bacterium Escherichia coli. According to Wiest, the model provides new insights into which parts of the enzyme are important for electron transfer that repairs the damage.

DNA photolyase and other mechanisms are used by many organisms, suc h as yeast and algae -- but not humans -- to protect against damage by ultraviolet light. By understanding how the protection mechanisms in these organisms work, scientists may be able to develop ways to protect humans from these types of skin cancer, Wiest says.

"To the best of our knowledge, our model is the first to explain all the pertinent experimental data -- binding and alkylation studies, spectroscopic data, rate constants and mutagenesis results -- in a consistent fashion," Wiest says. "It is

Contact: Olaf Wiest
University of Notre Dame

Page: 1 2

Related medicine news :

1. Advances in Uterine Leiomyoma Research: 2nd NIH International Congress
2. Advances in plasma physics at Annual APS Meeting
3. Advances in plasma physics at Annual APS Meeting
4. Advanced, precise radiation may boost limb-sparing therapy for sarcoma
5. Advances in understanding brain circuits responsible for tics in Tourettes shed light on disorder
6. Advances in Skeletal Anabolic Agents for the Treatment of Osteoporosis: A scientific meeting
7. Advances emerging in hepatitis management
8. Advanced small-cell lung cancer patients
9. Advances in prevention and treatment research hold promise for pipeline
10. Advances in MRI imaging may lead to new standards for faster diagnosis of multiple sclerosis
11. Peanut Allergy: Major Advances in Treatment and Education

Post Your Comments:

(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The American ... to become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer ... Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader ... been awarded a contract by the Center for Medicare and Medicaid Services (CMS). ... the enterprise use of Agile methodologies in a consistent and high value manner ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
(Date:9/23/2017)... 22, 2017 Janssen Biotech, Inc. (Janssen) announced ... from the U.S. Food and Drug Administration (FDA) for ... for the treatment of moderately to severely active rheumatoid ... data are needed to further evaluate the safety of ... RA. "We ...
(Date:9/18/2017)... , Pa. and KALAMAZOO, Mich. , Sept. ... Penn. , and OptiMed Specialty Pharmacy of ... partnership to offer a strategic hub service that expedites ... highly sought-after personal spirometer, Spiro PD 2.0, and wellness ... A spirometer is a medical device used to measure ...
Breaking Medicine Technology:
Cached News: