Advance reported in search for skin cancer treatment

In a search for skin cancer treatments, chemists at the University of Notre Dame have constructed a computer model of the chemical structure of an enzyme that many organisms use to repair DNA damaged by ultraviolet light. Their findings are reported in the June 9 issue of the Journal of the American Chemical Society and are now on the journal's website at http://pubs.acs.org/journals/jacsat/index.html.

According to Olaf Wiest, assistant professor of chemistry and biochemistry and principal investigator, the ultimate goal of the research is to produce an artificial enzyme for human use that could repair DNA damaged by ultraviolet light in humans. Such damage leads to certain types of skin cancer, which have reached almost endemic proportions. Skin cancer is now the most common form of cancer in the United States, with an estimated 1.4 million cases diagnosed annually. According to Wiest, the number of skin cancer patients has risen steadily over the past 20 years.

The computer model provides atomic details of the binding interactions of damaged DNA and DNA photolyase, the repair enzyme of the bacterium Escherichia coli. According to Wiest, the model provides new insights into which parts of the enzyme are important for electron transfer that repairs the damage.

DNA photolyase and other mechanisms are used by many organisms, suc h as yeast and algae -- but not humans -- to protect against damage by ultraviolet light. By understanding how the protection mechanisms in these organisms work, scientists may be able to develop ways to protect humans from these types of skin cancer, Wiest says.

"To the best of our knowledge, our model is the first to explain all the pertinent experimental data -- binding and alkylation studies, spectroscopic data, rate constants and mutagenesis results -- in a consistent fashion," Wiest says. "It is

Contact: Olaf Wiest
University of Notre Dame

Page: 1 2

Related medicine news :

1. Advances in Uterine Leiomyoma Research: 2nd NIH International Congress
2. Advances in plasma physics at Annual APS Meeting
3. Advances in plasma physics at Annual APS Meeting
4. Advanced, precise radiation may boost limb-sparing therapy for sarcoma
5. Advances in understanding brain circuits responsible for tics in Tourettes shed light on disorder
6. Advances in Skeletal Anabolic Agents for the Treatment of Osteoporosis: A scientific meeting
7. Advances emerging in hepatitis management
8. Advanced small-cell lung cancer patients
9. Advances in prevention and treatment research hold promise for pipeline
10. Advances in MRI imaging may lead to new standards for faster diagnosis of multiple sclerosis
11. Peanut Allergy: Major Advances in Treatment and Education

Post Your Comments:

(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... for healthcare compliance program management, will showcase a range of technology and learning ... Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 at ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed sound ... ... Jim Bertolina, PhD ... Tom Tefft ... device executive Josh Stopek , PhD, who has led R&D and business development teams ...
(Date:9/18/2017)... , Sept. 18, 2017 EpiVax, ... of bioinformatics and immune engineering, today announced ... influenza A (H7N9) vaccine. ... to seasonal influenza and presents a challenge ... prior exposure to be effective. Using state-of-the-art ...
(Date:9/12/2017)... N.J. , Sept. 12, 2017  Consumer reviews on the ... Hearing as the number one company for hearing aids, ranking ... and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high ...
Breaking Medicine Technology:
Cached News: