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Advances emerging in hepatitis management

cent were negative, 2.5 percent did not know the results of the HIV test, and 0.2 percent declined to answer.

"Although the majority of our HCV-infected patients have been tested for HIV, there is still a substantial proportion who were either not tested or were tested but did not know the results," said Edmund Bini, M.D., lead author of the study. "Better public health programs to improve HIV awareness among these patients and those at high risk of coinfection are important and should be developed."

Models to Predict Inflammation and Fibrosis in Patients with Chronic Hepatitis B (Abstract 103945*)

Patients who contract the hepatitis B virus can experience a brief, acute illness or a chronic, life-long infection. Those with chronic hepatitis B (HBV) can have serious complications such as cirrhosis, liver failure and liver cancer. Until now, it has been difficult to identify HBV patients who are likely to develop complications. A team of doctors led by Anna Lok, M.D. from the University of Michigan report today that they have developed a set of models based on laboratory test results to detect inflammation and fibrosis in the liver.

"We're pleased that for some chronic hepatitis B patients, demographic and laboratory data enable us to predict liver injury thus avoiding the need for a liver biopsy," said Anna Lok, M.D., lead author of the study. "Ability to determine the severity of liver injury using readily available clinical data will allow us to make more informed treatment decisions and improve quality of life for our patients."

To identify these predictive models, researchers reviewed baseline data and liver histology from HBV patients who participated in trials of adefovir therapy for both HBeAg+ (hepatitis B e antigen positive, 494 pts) and HBeAg- (hepatitis B e antigen negative, 178 pts). The analysis identified patients with Knodell inflammatory score of eight or greater, and those with an Ishak fibr
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17-May-2004


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