HOME >> MEDICINE >> NEWS
Aerosol form of cyclosporine hits key cellular target in lung transplant patients, researchers report at international meetin

An aerosol spray that delivers the anti-rejection drug cyclosporine directly to transplanted lungs appears to target an important biological process that other immunosuppressant drugs, including oral cyclosporine, have not been demonstrated to do. At the XVIII International Congress of the Transplantation Society, researchers from the University of Pittsburgh today presented preliminary results from an ongoing clinical study indicating aerosol cyclosporine can hinder the pumping mechanism a cell uses to spit out anything deemed undesirable, including drugs.

Understanding this mechanism could help researchers and clinicians identify ways to improve the concentrations of drugs within cells, making them more efficient and therapeutic, reported Vera Donnenberg, M.S., a graduate student working with University of Pittsburgh lung transplant surgeons Bartley P. Griffith, M.D., and Kenneth McCurry, M.D.

P-glycoprotein (P-gp) is a biological pump that was first identified in studies of cancer patients. The mechanism is so powerful that it is believed to be responsible for some types of cancer drug resistance -- the more the cell is exposed to the drug the more active and effective the pump becomes. With transplant patients, the mechanism makes it so that only about one third to one quarter of anti-rejection drugs are absorbed. Clinicians must compensate for this fact by delivering higher doses, but not without a price. Immunosuppressants, such as cyclosporine and tacrolimus, can produce a number of unwanted side effects as well as make patients more susceptible to life-threatening infections and tumor growth.

"Because organ transplant patients must take a life-long regimen of drugs to protect their donor organs from immune system attack, we were curious what effect the long-term exposure of such drugs would be to P-gp activity. Furthermore, we wanted to determine if delivering the drug directly to the transplanted organ -- where immune system cells wou
'"/>

Contact: Lisa Rossi
rossil@msx.upmc.edu
412-647-3555
University of Pittsburgh Medical Center
27-Aug-2000


Page: 1 2 3

Related medicine news :

1. Chemists Discover That Aerosol Clusters Play Larger Role In Generation Of Air Pollution
2. Mayo Clinic identifies key cellular process in prostate and other cancers
3. University of Utah study suggests cellular waste to blame for a form of blinding eye disease
4. New breast pap smear detects early cellular changes; May prevent onset of breast cancer
5. UVA researchers make cellular model of Parkinsons disease
6. How the cellular garbage disposal grinds to a halt to cause Batten disease
7. The Niemann Pick C Lesion and the role of intracellular lipid sorting in humandisease
8. Normal cellular enzyme becomes marker for Alzheimers disease
9. NHS target driven culture is failing patients
10. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
11. NHS stop-smoking services are insufficient to deliver national smoking targets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/12/2019)... ... 2019 , ... Remote Medical Technologies (RMT) will be a ... Annual Meeting being held in National Harbor, Maryland on March 18th to the ... RMT’s Mobile-Cart Solution . These solutions are high-performance HD telepathology systems ...
(Date:3/12/2019)... ... 12, 2019 , ... Caring Transitions is pleased to recognize Caring Transitions North ... owned by mother/daughter team Donna and Nicole Rea with the support of their team. ... Donna and Nicole of Caring Transitions of North Dallas Suburbs drove them to be ...
(Date:3/12/2019)... ... March 12, 2019 , ... When it comes to selecting ... to treat pain and diseases of joints, muscles, tendons and ligaments, “choose wisely,” ... the movie Indiana Jones. , “Some clinics and health centers have been built ...
(Date:3/12/2019)... , ... March 12, 2019 , ... A recent report ... facilities. Focusing on a series of Idaho case studies, the report argues that charter ... These arguments, while focused on Idaho in this particular report, have been made with ...
(Date:3/12/2019)... ... March 12, 2019 , ... The U.S. healthcare industry has ... each patient moving through different care settings. With a shared goal of providing ... ® today announced its support for broader discussions about the unique patient identifier ...
Breaking Medicine News(10 mins):
(Date:3/16/2019)... Hartford, CT (PRWEB) , ... March 16, 2019 , ... ... Ryaz Ansari are proud to announce that they are launching the JawFixers Implant Synergy ... March 27, 2019. This series is designed for implant clinicians to better understand the ...
(Date:3/15/2019)... , ... March 15, 2019 , ... Peter Saltonstall ... will be the keynote speaker at Keck Graduate Institute’s 18th annual commencement ceremony on ... CEO in 2008 after he served for more than 30 years as a senior ...
(Date:3/14/2019)... WARNER ROBINS, Ga. (PRWEB) , ... March 14, ... ... small minority-owned business enterprise (MBE) LOUi Consulting Group, Inc. (LCGI) its fourth consecutive ... DHA has awarded LCGI a $7M, 22-month contract to maintain the computer servers ...
Breaking Medicine Technology:
Cached News: