HOME >> MEDICINE >> NEWS
Aerosol form of cyclosporine hits key cellular target in lung transplant patients, researchers report at international meetin

An aerosol spray that delivers the anti-rejection drug cyclosporine directly to transplanted lungs appears to target an important biological process that other immunosuppressant drugs, including oral cyclosporine, have not been demonstrated to do. At the XVIII International Congress of the Transplantation Society, researchers from the University of Pittsburgh today presented preliminary results from an ongoing clinical study indicating aerosol cyclosporine can hinder the pumping mechanism a cell uses to spit out anything deemed undesirable, including drugs.

Understanding this mechanism could help researchers and clinicians identify ways to improve the concentrations of drugs within cells, making them more efficient and therapeutic, reported Vera Donnenberg, M.S., a graduate student working with University of Pittsburgh lung transplant surgeons Bartley P. Griffith, M.D., and Kenneth McCurry, M.D.

P-glycoprotein (P-gp) is a biological pump that was first identified in studies of cancer patients. The mechanism is so powerful that it is believed to be responsible for some types of cancer drug resistance -- the more the cell is exposed to the drug the more active and effective the pump becomes. With transplant patients, the mechanism makes it so that only about one third to one quarter of anti-rejection drugs are absorbed. Clinicians must compensate for this fact by delivering higher doses, but not without a price. Immunosuppressants, such as cyclosporine and tacrolimus, can produce a number of unwanted side effects as well as make patients more susceptible to life-threatening infections and tumor growth.

"Because organ transplant patients must take a life-long regimen of drugs to protect their donor organs from immune system attack, we were curious what effect the long-term exposure of such drugs would be to P-gp activity. Furthermore, we wanted to determine if delivering the drug directly to the transplanted organ -- where immune system cells wou
'"/>

Contact: Lisa Rossi
rossil@msx.upmc.edu
412-647-3555
University of Pittsburgh Medical Center
27-Aug-2000


Page: 1 2 3

Related medicine news :

1. Chemists Discover That Aerosol Clusters Play Larger Role In Generation Of Air Pollution
2. Mayo Clinic identifies key cellular process in prostate and other cancers
3. University of Utah study suggests cellular waste to blame for a form of blinding eye disease
4. New breast pap smear detects early cellular changes; May prevent onset of breast cancer
5. UVA researchers make cellular model of Parkinsons disease
6. How the cellular garbage disposal grinds to a halt to cause Batten disease
7. The Niemann Pick C Lesion and the role of intracellular lipid sorting in humandisease
8. Normal cellular enzyme becomes marker for Alzheimers disease
9. NHS target driven culture is failing patients
10. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
11. NHS stop-smoking services are insufficient to deliver national smoking targets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: