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African-American women with endometrial cancer have more aggressive cancer than Caucasian women

that these underlying molecular differences may partially explain the racial disparity in survival outcome.

More information about the studies can be found in the manuscripts:

"Racial disparity in survival among patients with advanced/recurrent endometrial adenocarcinoma: a Gynecologic Oncology Group Study"

"Racial disparity in global gene expression among patients with advanced endometrial adenocarcinoma"

"Both of these studies on racial disparities between African-American and Caucasian women with endometrial cancer suggest that a biologic reason may in part underlie the 'aggressive' endometrial cancers that develop in some African-American patients," said LTC Larry Maxwell, MD, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center. "Further research is needed to determine how these differences can be studied to help identify better therapies for high-risk minority groups."

The authors of the first study are: LTC G. Larry Maxwell, MD, Walter Reed Army Medical Center and the National Cancer Institute; G.V.R. Chandramouli, PhD, National Cancer Institute; Lou Dainty, MD, Walter Reed Army Medical Center; Tracy Litzi, MS, National Cancer Institute; Michael A. Bidus, MD, Walter Reed Army Medical Center; Andrew Berchuck, MD, Duke University Medical Center; J. Carl Barrett, PhD, National Cancer Institute; and John I. Risinger, PhD, National Cancer Institute.

The authors of the second study are: LTC G. Larry Maxwell, MD, Walter Reed Army Medical Center and the National Cancer Institute; Chunqiao Tian, MD, Gynecologic Oncology Group Statistical and Data Center; John I. Risinger, PhD, National Cancer Institute; Carol Brown, MD, Memorial Sloan Kettering; Tate Thigpen, MD, University of Mississippi Medical Center; Gini Fleming, MD, University of Chicago; Holly Gallion, MD, Precision Therapeutics; and Wendy Brewster, MD, University of California Irvine Medical Center.

According to the American
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Contact: Sarah Handza
202-441-3712
Society of Gynecologic Oncologists
22-Mar-2005


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