Alcohol researchers confirm molecular culprit of alcohol-induced liver damage

A study reported in the October issue of Gastroenterology (Volume 177, pages 1-12) shows that tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory protein, plays an important role in the development of early liver damage associated with alcohol consumption. Researchers from the University of North Carolina at Chapel Hill (UNC-CH) found that wild-type mice fed alcohol continuously over four weeks exhibited liver pathology almost seven times as severe as that in genetically selected mice without the TNF-alpha receptor (TNF-R1).

"This major increase in our understanding of the mechanisms of liver injury brings us one step closer to therapies for alcoholic liver disease," said Enoch Gordis, M.D., Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA), a component of the National Institutes of Health.

The placebo-controlled study offers the first solid proof that TNF-alpha mediates the development of early liver injury associated with long-term alcohol consumption. The exact role of TNF-alpha in liver disease pathogenesis is not clear, although this cytokine earlier was associated with high mortality from alcoholic hepatitis and TNF-alpha antibodies have been known to exert a protective effect on liver cells against alcohol attack.

Supported by a grant from the NIAAA, the researchers combined gene knockout technology and the enteral feeding techniques originally developed by Tsukamoto and French to allow continuous tube infusion of a high-fat diet with alcohol into mice without severely limiting their mobility. The research team assessed liver enzyme levels, degree of steatosis (fatty liver), inflammation, and necrosis as liver damage indicators.

"The use of animals lacking TNF-alpha receptors provides a direct way to test the hypothesis that this cytokine is important in the initiation and progression of alcohol-induced liver injury," said senior study author Ronald Thurman, Ph.D., professor of pharmacology and nutrition at the

Contact: Ann Bradley
NIH/National Institute on Alcohol Abuse and Alcoholism

Page: 1 2

Related medicine news :

1. Alcohol relapse adversely affects 10-year liver transplant survival
2. Alcohol intervention attempted for violent males
3. Alcohols damaging effects on adolescent brain function
4. Alcohol drinkers three times as likely to die from injury
5. Alcohol: Global burden on health similar to tobacco and high blood pressure
6. Alcoholics can have deficits in visuoperception and frontal executive function despite sobriety
7. RFA safe for treating liver tumors pushing on GI tract; Alcohol injection makes RFA more effective
8. Alcohol consumption may be associated with irregular heart beat in men
9. Alcohol use and victimization among college women
10. Alcohol limit for drink driving should be much lower
11. Alcohol-related emergency department visits higher than previously thought

Post Your Comments:

(Date:12/4/2019)... CARDIFF BY THE SEA, Calif. (PRWEB) , ... ... ... Prickly Pear fruit, trademarked as Tex-OE, Opuntia Mesocarp Extract®, provides protection from disruptions ... amazing extract, effective at countering the menace of Jet Lag, is available in ...
(Date:12/4/2019)... ... December 04, 2019 , ... Healthcare Real Estate Insights™ ... national awards dedicated to recognizing excellence in the areas of healthcare real estate ... nine different categories during the GlobeSt Healthcare Conference today in Scottsdale, Ariz. , ...
(Date:12/4/2019)... (PRWEB) , ... December 04, 2019 , ... UNC Health ... easily find their way around the campuses of UNC Medical Center in Chapel Hill ... two hospitals, parking garages, clinics and more. , The free interactive app, developed by ...
(Date:12/2/2019)... YORK (PRWEB) , ... December 02, 2019 , ... More ... year at midnight on December 31. While many people spend their tax-free funds throughout ... ball drops on New Year’s Eve. In an effort to help account holders use ...
(Date:12/2/2019)... ... December 02, 2019 , ... Interim HealthCare Inc. , a ... the 2019 Workforce: Optimas Awards . Selected for its multi-pronged approach to building ... help combat the nation’s caregiver shortage. By 2025, the U.S. will need to hire ...
Breaking Medicine News(10 mins):
(Date:12/4/2019)... FOREST, Calif. (PRWEB) , ... December 04, 2019 ... ... technology company providing healthcare professionals with minimally invasive technologies to treat chronic pain ... procedures performed with the Tenex Health TX® technology. , Dr. Bernard ...
(Date:12/4/2019)... (PRWEB) , ... December 04, 2019 , ... ... physicians to better manage their COPD patient’s symptoms, joined forces nearly a year ... patients immediate access to in-person care at times when the attention is most ...
(Date:12/2/2019)... , ... December 02, 2019 , ... ... of A Mission for Michael, an intensive mental health facility, announced it has ... oversee client relations, business development and national advocacy efforts. , "We are proud ...
Breaking Medicine Technology:
Cached News: