HOME >> MEDICINE >> NEWS
Alcohol researchers find genetic locus of human brain wave

Bernice Porjesz, Ph.D., Department of Psychiatry, State University of New York, Health Sciences Center at Brooklyn, and others from six of the nine universities that comprise NIAAA's Collaborative Study of the Genetics of Alcoholism (COGA) report in today's online version of the Proceedings of the National Academy of Sciences (99[6]:3729-3733) significant linkage and linkage disequilibrium between beta brain wave (EEG) frequency and a cluster of gamma-aminobutyric acid type A (GABAA) receptor genes on human chromosome 4. Conducted in the laboratory of COGA Principal Investigator Dr. Henri Begleiter, the study is coauthored by Laura Almasy, Ph.D., Howard J. Edenberg, Ph.D., and Theodore Reich, Ph.D., among others.

"Drs. Porjesz and Begleiter are the first to find a specific genetic locus associated with fundamental human brain oscillations. Their work contributes to understanding of brain neuroelectric activity and expedites our search for alcoholism risk and protective genes," said NIAAA Acting Director Raynard S. Kington, M.D., Ph.D.

Since the 1929 discovery of the human electroencephalogram (EEG), scientists have measured brain electrical activity, displayed as undulating lines with "peaks" and "valleys" called waves. Oscillations in these waves represent important features of information processing and are highly heritable. Beta EEG frequency, elevated in alcoholics and their alcohol-nave offspring, for some years has been regarded as a possible marker of alcoholism susceptibility. While its specific functional role is not yet defined, beta wave oscillation reflects heightened activity of the underlying neuronal network, scientists believe.

Activity of GABAA, the primary receptor subtype of the inhibitory brain neurotransmitter GABA, is responsible for nerve cell inhibition throughout the brain. Mounting evidence from human and animal studies implicates GABAA in the development of tolerance to and dependence on alcohol and in genetic lia
'"/>

Contact: Ann Bradley
301-443-0595
NIH/National Institute on Alcohol Abuse and Alcoholism
12-Mar-2002


Page: 1 2

Related medicine news :

1. Alcohol relapse adversely affects 10-year liver transplant survival
2. Alcohol intervention attempted for violent males
3. Alcohols damaging effects on adolescent brain function
4. Alcohol drinkers three times as likely to die from injury
5. Alcohol: Global burden on health similar to tobacco and high blood pressure
6. Alcoholics can have deficits in visuoperception and frontal executive function despite sobriety
7. RFA safe for treating liver tumors pushing on GI tract; Alcohol injection makes RFA more effective
8. Alcohol consumption may be associated with irregular heart beat in men
9. Alcohol use and victimization among college women
10. Alcohol limit for drink driving should be much lower
11. Alcohol-related emergency department visits higher than previously thought

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/13/2017)... ATLANTA , Sept. 13, 2017   OrthoAtlanta ... to the Atlanta Football Host Committee (AFHC) for the 2018 ... Monday, Jan. 8, 2018, at Mercedes-Benz Stadium in ... part of the AFHC "I,m In" campaign, participating in many ... ...
Breaking Medicine Technology:
Cached News: