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Alefacept effective in treating patients with psoriasis

CHICAGO Patients with psoriasis treated with the drug alefacept experienced a reduction in severity of their skin disease, according to an article in the December issue of The Archives of Dermatology, one of the JAMA/Archives journals.

Psoriasis is a chronic, inflammatory skin disorder. According to the article, scientific and clinical evidence suggests that T cells, specialized cells involved in the immune response, are involved in psoriasis. Skin severely affected by psoriasis has been observed to have high levels of CD4+ and CD8+ memory T cells (two types of T cells). Previous experimental studies have shown that elimination of T cells reduced the severity of psoriasis.

Kenneth B. Gordon, M.D., of Loyola University Medical Center, Maywood, Ill., and colleagues examined the effects of intravenous alefacept on the severity of psoriasis and T cell levels.

The researchers conducted a phase 3 clinical trial involving 553 patients with chronic psoriasis. The patients were randomized into one of three groups. Each group participated in a 12 week course of treatment (or placebo), followed by a twelve week period of observation without any drugs. Then, for eligible patients, there was a second 12 week course of treatment (or placebo) and another 12 weeks of observation.

  • group 1 7.5 milligrams of intravenous alefacept each week for both courses
  • group 2 7.5 milligrams intravenous alefacept each week in the first course, and 7.5 milligrams intravenous placebo each week for the second course
  • group 3 7.5 milligrams intravenous placebo each week in the first course, and 7.5 milligrams intravenous alefacept each week in the second course

    The researchers found that one or two courses of alefacept reduced CD4+ and CD8+ memory T cell counts. Patients who received alefacept in course 1 with the largest decrease in T cell counts experienced the greatest reduction in disease severity. The benefits
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  • Contact: Joanne Swanson
    708-216-2445
    JAMA and Archives Journals
    15-Dec-2003


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