HOME >> MEDICINE >> NEWS
Altered cyclin E protein leads to genetic instability in breast cancer

SAN ANTONIO -- Researchers at The University of Texas M. D. Anderson Cancer Center have found a protein linked to poor outcome in breast cancer is often associated with genetic instability and increased resistance to endocrine therapy.

The study, presented at the San Antonio Breast Cancer Symposium, provides a molecular model for the 25 percent of breast cancer patients who have high levels of "low molecular weight" cyclin E in their tumors.

"We want to come up with a better mode of therapy for patients with this form of cyclin E and this model system may provide a biological tool for drug targeting," says the study's lead researcher, Khandan Keyomarsi, Ph.D., associate professor in experimental radiation oncology.

Last year, Keyomarsi and her colleagues found in a study of about 400 patients that patients with high levels of low molecular weight cyclin E were significantly more likely to have an aggressive, invasive breast cancer. The protein, which is involved in regulation of a cell's living cycle, appears to be a much better predictor of patient outcome than any current predictive marker, says Keyomarsi, who reported the findings in the New England Journal of Medicine.

Currently, the prognosis for women diagnosed with breast cancer is determined by assessing whether tumor cells have spread to lymph nodes. But some women who have cancer cells in the lymph nodes never have a recurrence, while others whose cancer has not spread do have a recurrence. Yet many women undergo chemotherapy because of the uncertainty of their prognosis.

If an accurate predictive marker were available, many women could be spared chemotherapy, and those with the altered cyclin E protein may be offered more aggressive therapy from their initial diagnosis, Keyomarsi says.

Using the cell line model system in this study, led by Said Akli, Ph.D., an instructor in Keyomarsi's laboratory, the investigators found that low molecular weight cyclin
'"/>


3-Dec-2003


Page: 1 2

Related medicine news :

1. Altered mice provide model of rare childhood disease, NIH and Georgetown researchers find
2. Altered Brain Chemistry In Bulimia Nervosa Patients Persists After Recovery, According To UPMC Researchers
3. Regular cycling can improve sexual function in men with heart failure
4. UC Davis recycling expert wins Stockholm Water Prize
5. Targeting mutant B-Raf protein reduces melanoma development
6. Mechanism of RNA recoding: New twists in brain protein production
7. Epstein-Barr virus protein crucial to its role in blood cancers
8. Neuronal death and processing of Tau protein in Alzheimers disease
9. CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
10. Brain synapse formation linked to proteins, Stanford study finds
11. Stat5 protein inhibits spread of breast cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance ... care insurance companies have a waiver for care if the client has a cognitive ... the family pays for care, is often waived, so the benefits from their insurance ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized ... have expanded their existing home health joint venture through an agreement, effective October ... a joint venture home health company with Asante, delivering clinically integrated care, for ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & ... by Moonlight to raise money for the American Heart Association Heart Walk. Teams of ... will work together to keep their treadmills moving for 5 hours. Treadmills will start ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/25/2017)... AMSTERDAM , Sept. 25, 2017   ... Trial Master File solutions, today—from the IQPC Trial ... Amsterdam , NL)—announced that EastHORN Clinical Services ... its clinical programs and TMF management. EastHORN, a ... Montrium,s eTMF platform to increase transparency to enable ...
(Date:9/19/2017)... -- HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy ... team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D ...
Breaking Medicine Technology:
Cached News: