HOME >> MEDICINE >> NEWS
Altered cyclin E protein leads to genetic instability in breast cancer

SAN ANTONIO -- Researchers at The University of Texas M. D. Anderson Cancer Center have found a protein linked to poor outcome in breast cancer is often associated with genetic instability and increased resistance to endocrine therapy.

The study, presented at the San Antonio Breast Cancer Symposium, provides a molecular model for the 25 percent of breast cancer patients who have high levels of "low molecular weight" cyclin E in their tumors.

"We want to come up with a better mode of therapy for patients with this form of cyclin E and this model system may provide a biological tool for drug targeting," says the study's lead researcher, Khandan Keyomarsi, Ph.D., associate professor in experimental radiation oncology.

Last year, Keyomarsi and her colleagues found in a study of about 400 patients that patients with high levels of low molecular weight cyclin E were significantly more likely to have an aggressive, invasive breast cancer. The protein, which is involved in regulation of a cell's living cycle, appears to be a much better predictor of patient outcome than any current predictive marker, says Keyomarsi, who reported the findings in the New England Journal of Medicine.

Currently, the prognosis for women diagnosed with breast cancer is determined by assessing whether tumor cells have spread to lymph nodes. But some women who have cancer cells in the lymph nodes never have a recurrence, while others whose cancer has not spread do have a recurrence. Yet many women undergo chemotherapy because of the uncertainty of their prognosis.

If an accurate predictive marker were available, many women could be spared chemotherapy, and those with the altered cyclin E protein may be offered more aggressive therapy from their initial diagnosis, Keyomarsi says.

Using the cell line model system in this study, led by Said Akli, Ph.D., an instructor in Keyomarsi's laboratory, the investigators found that low molecular weight cyclin
'"/>


3-Dec-2003


Page: 1 2

Related medicine news :

1. Altered mice provide model of rare childhood disease, NIH and Georgetown researchers find
2. Altered Brain Chemistry In Bulimia Nervosa Patients Persists After Recovery, According To UPMC Researchers
3. Regular cycling can improve sexual function in men with heart failure
4. UC Davis recycling expert wins Stockholm Water Prize
5. Targeting mutant B-Raf protein reduces melanoma development
6. Mechanism of RNA recoding: New twists in brain protein production
7. Epstein-Barr virus protein crucial to its role in blood cancers
8. Neuronal death and processing of Tau protein in Alzheimers disease
9. CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
10. Brain synapse formation linked to proteins, Stanford study finds
11. Stat5 protein inhibits spread of breast cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, ... dedicated to helping service members that have been wounded in battle and their families. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at www.diabetesscholars.org by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening to conquer ... in advanced audiology and hearing aid technology, has today ... world,s first internet connected hearing aid that opens up ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... , TwinLink™ - the first dual communication ...
Breaking Medicine Technology:
Cached News: