HOME >> MEDICINE >> NEWS
Altered cyclin E protein leads to genetic instability in breast cancer

SAN ANTONIO -- Researchers at The University of Texas M. D. Anderson Cancer Center have found a protein linked to poor outcome in breast cancer is often associated with genetic instability and increased resistance to endocrine therapy.

The study, presented at the San Antonio Breast Cancer Symposium, provides a molecular model for the 25 percent of breast cancer patients who have high levels of "low molecular weight" cyclin E in their tumors.

"We want to come up with a better mode of therapy for patients with this form of cyclin E and this model system may provide a biological tool for drug targeting," says the study's lead researcher, Khandan Keyomarsi, Ph.D., associate professor in experimental radiation oncology.

Last year, Keyomarsi and her colleagues found in a study of about 400 patients that patients with high levels of low molecular weight cyclin E were significantly more likely to have an aggressive, invasive breast cancer. The protein, which is involved in regulation of a cell's living cycle, appears to be a much better predictor of patient outcome than any current predictive marker, says Keyomarsi, who reported the findings in the New England Journal of Medicine.

Currently, the prognosis for women diagnosed with breast cancer is determined by assessing whether tumor cells have spread to lymph nodes. But some women who have cancer cells in the lymph nodes never have a recurrence, while others whose cancer has not spread do have a recurrence. Yet many women undergo chemotherapy because of the uncertainty of their prognosis.

If an accurate predictive marker were available, many women could be spared chemotherapy, and those with the altered cyclin E protein may be offered more aggressive therapy from their initial diagnosis, Keyomarsi says.

Using the cell line model system in this study, led by Said Akli, Ph.D., an instructor in Keyomarsi's laboratory, the investigators found that low molecular weight cyclin
'"/>


3-Dec-2003


Page: 1 2

Related medicine news :

1. Altered mice provide model of rare childhood disease, NIH and Georgetown researchers find
2. Altered Brain Chemistry In Bulimia Nervosa Patients Persists After Recovery, According To UPMC Researchers
3. Regular cycling can improve sexual function in men with heart failure
4. UC Davis recycling expert wins Stockholm Water Prize
5. Targeting mutant B-Raf protein reduces melanoma development
6. Mechanism of RNA recoding: New twists in brain protein production
7. Epstein-Barr virus protein crucial to its role in blood cancers
8. Neuronal death and processing of Tau protein in Alzheimers disease
9. CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
10. Brain synapse formation linked to proteins, Stanford study finds
11. Stat5 protein inhibits spread of breast cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... December 07, 2016 , ... A. Kevin Spann Insurance, a ... throughout the Five Boroughs, is launching a charity drive to raise funds that will ... traditions and spirit of marines and Navy FMF Corpsmen. Working closely with the MCL, ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... to announce that its fully redesigned website, which launched October 17, 2016, features ... sleek responsive design and easy-to-navigate layout. Visitors and patients can discover the latest ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... Texas, is condemning "scam operations" carried out by unethical locksmith companies and is ... operations to a halt. According to Texas Premier Locksmith, these fraudulent locksmith services ...
(Date:12/7/2016)... ... 2016 , ... "ProBrand Flip allows FCPX editors to create unique logo reveals ... of Pixel Film Studios. , ProBrand Flip includes 30 flip book reveal animations. Easily ... from a variety of flip book animations. In Addition, users can modify each preset ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... Wellness (IFW) Program at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin brings nearly ... team of three acupuncturists to help patients realize their family building goals. ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7,2016  Based on ... delivery industry, Frost & Sullivan recognizes Nemaura ... & Sullivan Award for Enabling Technology Leadership. ... the loopholes in traditional drug delivery technologies, ... liquid microneedle-based drug delivery technologies, Memspatch and ...
(Date:12/7/2016)... , Dec. 7, 2016  Ionis Pharmaceuticals, Inc. (NASDAQ: ... management will present a company overview at the BMO Capital Markets ... New York, NY . A live webcast ... section of the Ionis website.  The replay will be available within ... ...
(Date:12/7/2016)... , December 7, 2016 According ... Research titled , Global Market Study on Multiplex Detection Immunoassay: ... , the global multiplex detection immunoassay market is expected to ... 2016-2024. ... ,      ...
Breaking Medicine Technology:
Cached News: