HOME >> MEDICINE >> NEWS
Alzheimer's pathology reduced, longevity improved in mouse model, Gladstone study shows

Removal of an enzyme that regulates the activity of many proteins can suppress key features of Alzheimer's disease in experimental models, researchers at the Gladstone Institute of Neurological Disease (GIND) recently reported in the Journal of Neuroscience (May 12, 2004).

Using well-established mouse models of Alzheimer's disease, the investigators examined how changing levels of the enzyme Fyn affects key aspects of the disease, including accumulation of large clumps of amyloid proteins in the brain (so-called plaques) and changes in the complex neuronal networks in which memories are formed and stored. Genetic engineering strategies were used to increase or decrease the expression of Fyn, which regulates many other proteins through the attachment of specific groups of atoms known as phosphate groups.

The researchers determined that changing levels of Fyn had no effect on plaque formation or aberrant sprouting (the abnormal growth of nerve terminals, in which neuchemical messages are stored), indicating that these pathologies involve discrete molecular mechanisms. However, they observed that blocking Fyn expression prevented amyloid proteins from damaging synapses, the specialized connections between brain cells, and improved the longevity of mice. (Experimental mice with Alzheimer's-like disease otherwise die prematurely.) In contrast, increasing Fyn in the brain worsened synaptic damage, and also increased the number of premature deaths in the mice.

Loss of synapses and abnormal outgrowth of nerve terminals occur both in people with Alzheimer's disease and in transgenic mice producing human amyloid proteins in the brain (the model used in the study). Humans with the disease, like mice, die prematurely.

"Synaptic degeneration in Alzheimer's disease is like electrical circuits in a computer becoming faulty -- signals can no longer be transmitted through broken connections," says senior author and GIND director Lennart Mucke, MD, who
'"/>

Contact: John Watson
jwatson@gladstone.ucsf.edu
415-476-2557
University of California - San Francisco
19-May-2004


Page: 1 2

Related medicine news :

1. Chemical decoy shows promise for slowing Alzheimers by acting as decoy
2. Neuronal death and processing of Tau protein in Alzheimers disease
3. Researchers discover link between insulin and Alzheimers
4. New trials for counseling caregivers and patients with Alzheimers begin
5. Marijuana ingredient may stall decline from Alzheimers
6. Drugs used to treat Alzheimers in nursing homes are worsening sufferers illness
7. UT Southwestern doctors track Oklahoma Alzheimers patients via telemedicine
8. Contrary to previous findings, smoking is detrimental to patients with Alzheimers
9. Nanoscale diagnostic sets sights on Alzheimers
10. New test is first step in early detection of Alzheimers disease
11. Older people with the Alzheimers gene find it harder to remember to remember even if healthy

Post Your Comments:
(Date:5/26/2015)... Ill. (PRWEB) May 26, 2015 Degeneration ... an early marker of specific types of Alzheimer’s disease ... new study published in the journal Radiology. , ... M.D., Ph.D., co-author of the study conducted at the ... Italy. “However, white matter damage has a central role ...
(Date:5/26/2015)... 27, 2015 Readers who struggle with ... help in author Chester Litvin ’s new book, ... Code” (published by Trafford Publishing). , Litvin, who is ... stimulating the brain. This book will guide readers through ... sensory brain cells . He shares his patented ...
(Date:5/26/2015)... Forex Income Boss is a new system for traders ... the foreign exchange market. The system, which was developed ... to help traders locate perfect setups with a higher ... trading system is the talk of the town in ... product reviewer at HonestyFirstReview.com. "While Horn's products are always ...
(Date:5/26/2015)... Rolling Meadows, Ill. (PRWEB) May 26, 2015 ... and cosmetic procedures in 2014, according to survey results ... , With increases in skin cancer treatments and several ... two years ago but remained steady overall compared to ... a row, skin cancer treatments ranked as the most-performed ...
(Date:5/26/2015)... May 26, 2015 Over 700 doctors, ... letter to the secretaries of the U.S. Department ... Human Services urging them to embrace the 2015 Dietary ... more plants for human health, economic prosperity, and our ... medicine signed the letter, including: Dr. David Katz, founding ...
Breaking Medicine News(10 mins):Health News:RSNA: Imaging Test May Identify Biomarker of Alzheimer’s Disease 2Health News:RSNA: Imaging Test May Identify Biomarker of Alzheimer’s Disease 3Health News:Chester Litvin’s New Book Offers ‘Tune-Up’ for Brain Cells 2Health News:Chester Litvin’s New Book Offers ‘Tune-Up’ for Brain Cells 3Health News:Forex Income Boss - Review Of Russ Horn's New FX Trading System Released 2Health News:New ASDS Survey: 9.5 Million Treatments Performed in 2014 2Health News:New ASDS Survey: 9.5 Million Treatments Performed in 2014 3Health News:New ASDS Survey: 9.5 Million Treatments Performed in 2014 4Health News:700 Doctors, Health Professionals, Including the American College of Lifestyle Medicine, Support Dietary Guidelines Message to Eat Less Meat, More Plants 2Health News:700 Doctors, Health Professionals, Including the American College of Lifestyle Medicine, Support Dietary Guidelines Message to Eat Less Meat, More Plants 3
(Date:5/26/2015)... May 26, 2015 Depomed, Inc. (NASDAQ: DEPO ... healthcare conferences in June. The 2015 Jefferies ... Jefferies conference is scheduled for 3:00 pm EDT (12:00 noon ... JMP Securities Life Sciences Conference in New York City.  The ... EDT (8:30 am PDT) Wednesday, June 24, 2015. ...
(Date:5/26/2015)... Generational Equity , a leading mergers and acquisitions advisor ... acquisition of its client, Peaks & Plains Inc. ... by Mi-Med Supply , headquartered in Vista, California.  ... Peaks & Plains is the only dual accredited ... patient care, and housekeeping equipment to long-term care facilities ...
(Date:5/26/2015)... , May 26, 2015  Juniper Pharmaceuticals, ... pharmaceutical company focused on developing therapeutics that address ... that CFO George Elston will present ... Thursday, May 28, 2015Time: , 4:00 PM EDTLocation: ... & archive): , www.juniperpharma.com, under  ,Investor, ...
Breaking Medicine Technology:Depomed To Present At Healthcare Conferences In June 2Generational Equity Announces the Acquisition of Peaks & Plains Inc. by Mi-Med Supply 2Juniper Pharmaceuticals to Present at Investor Conference on May 28, 2015 2
Cached News: