HOME >> MEDICINE >> NEWS
American Heart Association Comment On New England Journal Of Medicine Report OnCalcium Antagonist Nisoldipine (March 5 issue)

A study in the NEJM titled "The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension," finds an increased risk of fatal and non-fatal heart attacks among individuals taking the calcium antagonist nisoldipine compared to individuals taking enalapril, which is a member of a class of drugs called ACE-inhibitors.

The study provides more evidence that calcium antagonists (preferred term for calcium channel blockers) may pose risks for certain people, including those with diabetes and coronary heart disease. Past studies of short-acting calcium antagonists have also found increased risk of cardiovascular complications. It was thought that the longer-acting drugs did not pose similar risks. However, the current study used a long-acting drug.

Speaking for the American Heart Association, Joseph Izzo, M.D., says "individuals taking calcium antagonists should not panic and stop medication without consulting a physician. However, individuals with both known cardiovascular disease and diabetes may want to talk to their physicians about choosing another type of high blood pressure drug, or to use the calcium antagonist in combination with other agents that are complementary." Izzo is a member of the American Heart Association's Continuing Education Committee.

Calcium antagonists dilate (relax) constricted blood vessels and thus reduce blood pressure. However, this vasodilator action may force the heart to pump harder and may also stimulate stress hormones. This action is the opposite of beta-blockers that limit cardiac output, notes Izzo, professor of medicine and pharmacology at the State University of New York, Buffalo.

The study, by Raymond Estacio, M.D., of the Colorado Prevention Center, Denver, included 470 individuals who had high blood pressure and non-insulin dependent diabetes. The trial compared an ACE-inhibitor with a calcium antagonist in the p
'"/>

Contact: Carole Bullock
caroleb@amhrt.org
214-705-1279
American Heart Association
3-Mar-1998


Page: 1 2

Related medicine news :

1. Consumers with disabilities empowered by American Disabilities Act
2. Definition of persistent vegetative state available from American Academy of Neurology
3. African-American women with endometrial cancer have more aggressive cancer than Caucasian women
4. New colorectal cancer screening recommendations for African Americans
5. American Thoracic Society Journal news tips for March 2005 (second issue)
6. Community care tops medical care at preventing heart disease in black Americans
7. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
8. Obesity among African-American stroke survivors increases risk factors for recurrent stroke
9. Awards & fellowships at the International & American Association for Dental Research General Session
10. American Academy of Neurology presents 57th Annual Meeting in Miami Beach
11. News tips from the 2005, 54th Annual Scientific Sessions of the American College of Cardiology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... As health professionals work to improve their approach to healthcare, there is a ... filling out a survey; in many cases health professionals and patients are working together ... research on the importance of active engagement with patients and members of the public ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... New York, NY (PRWEB) , ... October 13, 2017 , ... ... most influential people in business to advocate for action towards gender equality at their ... 18,000 views from around the globe, and reached a social audience of over 3 ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... to meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s ... experts and tested to meet the highest standard. , These products are ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... 28, 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), ... call and webcast on Friday, November 3, 2017, beginning ... ending at approximately 8:30 a.m. (CDT) / 9:30 a.m. ... 2017 financial performance and guidance for 2018, Hill-Rom executives ... enhance operational performance, and long-range financial outlook through 2020. ...
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
Breaking Medicine Technology:
Cached News: