American Heart Association Comment On New England Journal Of Medicine Report OnCalcium Antagonist Nisoldipine (March 5 issue)

revention and progression of diabetes in equal number of individuals. A secondary goal of the study was to determine if the drugs could prevent cardiovascular disease, a leading cause of death among individuals with diabetes.

The study found that nisoldipine (Sular) was linked with a higher rate of fatal and non-fatal heart attacks -- a total of 25 compared to five for enalapril in this particular group. Despite these striking differences, the authors of the study stress that "it is plausible that the findings resulted from a protective effect of enalapril and not a deleterious effect of nisoldipine."

Other calcium antagonists include: nimodipine (Nimotop); verapamil (Calen, Isoptin, Verelan); nicardipine (Cardene); diltiazem (Cardizem, Dilacor); isradipine (DynaCirc); amlodipine (Norvasc); felodipine (Plendil); nifedipine (Procardia); and bepridil (Vascor).


Contact: Carole Bullock
American Heart Association

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