pecific base reference values for the remodeling ratio. According to the authors, failure to achieve a ratio within the normal range despite the use of a bronchodilator suggested the presence of structural abnormalities in the airway wall, indicating a lack of full reversibility. Airway remodeling in this way occurred in 7.4 percent of the cohort at age 18 and 6.4 percent at age 26. This problem occurred in up to one-third of the patients with asthma. Remodeling was associated with male sex, low lung function values, asthma, and, in childhood, airway hyperresponsiveness. The research appears in the first issue for June of the American Thoracic Society's peer- reviewed American Journal of Respiratory and Critical Care Medicine.

CANADIAN INVESTIGATORS DISCOVER RARE
NEW INFANT DEVELOPMENTAL DISORDER

Canadian investigators have identified a new neonatal interstitial lung disease they call "pulmonary interstitial glycogenosis," which they believe is an infant developmental disorder rather than one caused by infection or inflammation. To develop their conclusion, the physician researchers looked at the clinical, radiologic, and pathologic findings from lung biopsies in seven infants with atypical noninfective respiratory disorders during their neonatal period. The authors believe that the pathology they saw had not been described previously and could represent a unique form of interstitial lung disease. Six of the seven infants showed favorable outcomes after being treated primarily with corticosteroids. One infant died from complications associated with extreme prematurity. Three of the cases were followed by the researchers for 6 years. Over that time, these three children showed both a clinical resolution of their problem and improved radiographic results. The study appears in the first issue for June of the American Thoracic Society peer-reviewed American Journal of Respiratory and Critical Care
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Contact: Cathy Carlomagno
ccarlomagno@thoracic.org
212-315-6442
American Thoracic Society
6-Jun-2002

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