HOME >> MEDICINE >> NEWS
Analysis of tamoxifen studies reveals slight increase of stroke risk

ST. PAUL, Minn. A recent analysis of tamoxifen studies completed since 1980 revealed an increased risk of stroke in women who were randomized to tamoxifen versus placebo or other therapies. Details of the analysis and the researchers' conclusions are reported in the October 12 issue of Neurology, the scientific journal of the American Academy of Neurology.

More than 250,000 U.S. women are diagnosed with breast cancer each year. Breast cancer accounts for nearly one in three cancers diagnosed in the U.S. and is the second leading cause of death for women. Fortunately, 90 percent of breast cancers are now diagnosed at localized and regional stages, for which five-year survival rates are 97 percent and 79 percent, respectively. Tamoxifen, a medication in pill form that interferes with the activity of estrogen, has been used for more than 20 years to treat patients with advanced breast cancer. It is used as adjuvant, or additional, therapy following primary treatment for early stage breast cancer. In women at high risk of developing breast cancer, tamoxifen reduces the chance of developing the disease.

In addition to its effects on breast cancer, the benefits of tamoxifen include increased bone mineral density, reduced risk of hip fractures, and lower levels of cholesterol. While tamoxifen is known to increase the risk of blood clotting in women with cancer, its relationship to stroke risk has been unclear. Because tamoxifen increases the risk of thromboembolism (a blood clot that has traveled from its site of origin to another vessel), its use could be associated with a higher risk of ischemic stroke (arterial obstruction) as compared to hemorrhagic (bleeding) stroke.

Researchers from Duke University Medical Center sought to determine the overall risk of both ischemic stroke and all strokes associated with tamoxifen. They conducted a systematic review of all clinical trials of tamoxifen published since 1980 using MEDLINE.

Nine
'"/>

Contact: Marilee Reu
mreu@aan.com
651-695-2789
American Academy of Neurology
11-Oct-2004


Page: 1 2

Related medicine news :

1. Analysis finds drug improves odds of complete stroke recovery
2. Analysis of study looks at why quitters return to smoking
3. Analysis suggests women treated for breast cancer do better with axillary node dissection
4. Retrospective Statistical Analysis Corroborates Early Results Of Randomized Breast Cancer Trials
5. New U-M Analysis Of Brain At Work
6. Meta-Analysis Of The Efficacy Of Sildenafil (ViagraTM) In The Treatment Of Severe Erectile Dysfunction
7. Digital Speech Analysis Tests Sobriety
8. Common antidepressants lower effects of tamoxifen in many women
9. Study finds women hesitant to take tamoxifen as preventive measure
10. Decision to take tamoxifen difficult for many women
11. Chemotherapy, but not tamoxifen, associated with stroke risk after breast cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... ... September 01, 2020 , ... Dr. Kiran Gill is ... surgery of the face, breast, and body. In 2018, she founded Aesthetics in ... surgery and aesthetic practice in Southwest Florida. Dr. Gill and her team offer ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... 1,400 N95 face masks to medical first responders across the United States. Since ... donations of personal protective equipment (PPE) medical centers , hospitals , ...
(Date:8/31/2020)... ... 31, 2020 , ... Smile Brands Inc., one of the ... States, today announced the grand opening of another affiliated Bright Now! Dental ... convenient hours, a comfortable office, and full-service care at the new Beaumont location. ...
(Date:8/31/2020)... ... 2020 , ... Dr. Chang has over 20 years of ... developmental disabilities, as well as supporting staff in caring for patients and families. ... and staff development. She joined the company in 2015 as Chief of Clinical ...
(Date:8/28/2020)... ... 28, 2020 , ... WHAT , Hespiro™ is a new ... conditions, including COVID-19, while reducing the need for scarce mechanical ventilators. It not ... and scrubs it free of carbon dioxide in a completely closed “rebreather” system, ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... SEATTLE (PRWEB) , ... August 31, 2020 , ... ... technology research and advisory guide, has named Cloudticity a Gold winner in the ... are industry and peer recogniti o ns from Network Products Guide ...
(Date:8/28/2020)... ... ... Dr. Mark Surrey has been in practice for over 25 years. He ... the Department of OBGYN at UCLA’s David Geffen School of Medicine. , He ... is a Clinical Director of Fellowship Training for UCLA & Cedars Sinai Reproductive Endocrinology. ...
(Date:8/27/2020)... ... August 27, 2020 , ... ... today announced the successful completion of their 2020 System and Organizational Controls (SOC) ... HITRUST® interim assessment and MARS-E compliance assessment. These achievements reflect their long-standing commitment ...
Breaking Medicine Technology:
Cached News: