HOME >> MEDICINE >> NEWS
Analysis of tamoxifen studies reveals slight increase of stroke risk

ST. PAUL, Minn. A recent analysis of tamoxifen studies completed since 1980 revealed an increased risk of stroke in women who were randomized to tamoxifen versus placebo or other therapies. Details of the analysis and the researchers' conclusions are reported in the October 12 issue of Neurology, the scientific journal of the American Academy of Neurology.

More than 250,000 U.S. women are diagnosed with breast cancer each year. Breast cancer accounts for nearly one in three cancers diagnosed in the U.S. and is the second leading cause of death for women. Fortunately, 90 percent of breast cancers are now diagnosed at localized and regional stages, for which five-year survival rates are 97 percent and 79 percent, respectively. Tamoxifen, a medication in pill form that interferes with the activity of estrogen, has been used for more than 20 years to treat patients with advanced breast cancer. It is used as adjuvant, or additional, therapy following primary treatment for early stage breast cancer. In women at high risk of developing breast cancer, tamoxifen reduces the chance of developing the disease.

In addition to its effects on breast cancer, the benefits of tamoxifen include increased bone mineral density, reduced risk of hip fractures, and lower levels of cholesterol. While tamoxifen is known to increase the risk of blood clotting in women with cancer, its relationship to stroke risk has been unclear. Because tamoxifen increases the risk of thromboembolism (a blood clot that has traveled from its site of origin to another vessel), its use could be associated with a higher risk of ischemic stroke (arterial obstruction) as compared to hemorrhagic (bleeding) stroke.

Researchers from Duke University Medical Center sought to determine the overall risk of both ischemic stroke and all strokes associated with tamoxifen. They conducted a systematic review of all clinical trials of tamoxifen published since 1980 using MEDLINE.

Nine
'"/>

Contact: Marilee Reu
mreu@aan.com
651-695-2789
American Academy of Neurology
11-Oct-2004


Page: 1 2

Related medicine news :

1. Analysis finds drug improves odds of complete stroke recovery
2. Analysis of study looks at why quitters return to smoking
3. Analysis suggests women treated for breast cancer do better with axillary node dissection
4. Retrospective Statistical Analysis Corroborates Early Results Of Randomized Breast Cancer Trials
5. New U-M Analysis Of Brain At Work
6. Meta-Analysis Of The Efficacy Of Sildenafil (ViagraTM) In The Treatment Of Severe Erectile Dysfunction
7. Digital Speech Analysis Tests Sobriety
8. Common antidepressants lower effects of tamoxifen in many women
9. Study finds women hesitant to take tamoxifen as preventive measure
10. Decision to take tamoxifen difficult for many women
11. Chemotherapy, but not tamoxifen, associated with stroke risk after breast cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Analysis tamoxifen studies reveals slight increase stroke risk

(Date:8/5/2015)... ... 05, 2015 , ... Social Security benefits are not keeping pace with rising ... The Senior Citizens League (TSCL). The record low growth in cost-of-living adjustments ... Social Security beneficiaries age 65 and older, says TSCL. , When asked to select ...
(Date:8/5/2015)... ... 2015 , ... A leader in Primary Care Continuing Medical Education (CME), ... Su Barnwell as its new Director of Program Management. , Su has over 16 ... worked for Primary Care Network (PCN) as the Director, Program Implementation as well as ...
(Date:8/5/2015)... , ... August 05, 2015 , ... Over 6,500 athletes ... of competition and camaraderie at the Special Olympics World Games 2015 (July 25 to ... largest international sporting competition held in Los Angeles since the 1984 Olympics, and the ...
(Date:8/4/2015)... ... 2015 , ... MONTICELLO, Fla. – After completing 2,400 hours in the Clinical ... journey as a clinician allowed Dr. Barbara Thomas-Reddick to gain the skills ... for patients, families, friends and staff, and she was able to witness after leaving ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... How cool ... share what inspires you via geolocation? The new "Now" feature will soon allow you ... will be able to inspire each other using the now feature. , Users will ...
Breaking Medicine News(10 mins):Health News:Majority of Older Americans Say Social Security Benefits Not Keeping up with Rising Household Costs, According to a New Survey from the Senior Citizens League 2Health News:Majority of Older Americans Say Social Security Benefits Not Keeping up with Rising Household Costs, According to a New Survey from the Senior Citizens League 3Health News:Leading Continuing Medical Education (CME) Provider, Continuing Education Company (CEC), hires expert Su Barnwell as Director of Program Management 2Health News:Leading Continuing Medical Education (CME) Provider, Continuing Education Company (CEC), hires expert Su Barnwell as Director of Program Management 3Health News:CPMA Member Podiatrists Ensure Fit Feet at the Special Olympics World Games in Los Angeles 2Health News:CPMA Member Podiatrists Ensure Fit Feet at the Special Olympics World Games in Los Angeles 3Health News:New book shows how ‘The Presence of a Chaplain’ affects lives 2Health News:New book shows how ‘The Presence of a Chaplain’ affects lives 3Health News:Ahhaa App Soon to Release the "Now" Feature 2
(Date:8/5/2015)... 2015  Butterfly Network was awarded today as ... Pioneers for 2015.  The company is democratizing medical ... surgery. By integrating its novel imaging platform with ... a virtuous cycle, learning as they image, and ... was chosen by a professional jury among hundreds ...
(Date:8/4/2015)... Karuna Pharmaceuticals, Inc. ("Karuna"), a PureTech ... product candidate for the treatment of schizophrenia, announced ... Award from the Wellcome Trust comprising an unsecured ... million. The funding, along with other capital, will ... KarXT, a potentially innovative therapy for the treatment ...
(Date:8/4/2015)... On August 3, 2015, a press conference on anti-virus and ... ceremony of a million masks by Wuhan Longfeixiang Technology Products ... . Wuhan Longfeixiang Technology Products ... Longfeixiang Industrial Group, which has successfully developed the globally ... mask, filling the global gap for masks of this ...
Breaking Medicine Technology:Butterfly Network Recognized as a Technology Pioneer by the World Economic Forum 2Karuna Receives Wellcome Trust Award to Advance Innovative Clinical Stage Product Candidate for the Treatment of Schizophrenia 2Karuna Receives Wellcome Trust Award to Advance Innovative Clinical Stage Product Candidate for the Treatment of Schizophrenia 3Karuna Receives Wellcome Trust Award to Advance Innovative Clinical Stage Product Candidate for the Treatment of Schizophrenia 4
Cached News: