HOME >> MEDICINE >> NEWS
Analysis of tamoxifen studies reveals slight increase of stroke risk

ST. PAUL, Minn. A recent analysis of tamoxifen studies completed since 1980 revealed an increased risk of stroke in women who were randomized to tamoxifen versus placebo or other therapies. Details of the analysis and the researchers' conclusions are reported in the October 12 issue of Neurology, the scientific journal of the American Academy of Neurology.

More than 250,000 U.S. women are diagnosed with breast cancer each year. Breast cancer accounts for nearly one in three cancers diagnosed in the U.S. and is the second leading cause of death for women. Fortunately, 90 percent of breast cancers are now diagnosed at localized and regional stages, for which five-year survival rates are 97 percent and 79 percent, respectively. Tamoxifen, a medication in pill form that interferes with the activity of estrogen, has been used for more than 20 years to treat patients with advanced breast cancer. It is used as adjuvant, or additional, therapy following primary treatment for early stage breast cancer. In women at high risk of developing breast cancer, tamoxifen reduces the chance of developing the disease.

In addition to its effects on breast cancer, the benefits of tamoxifen include increased bone mineral density, reduced risk of hip fractures, and lower levels of cholesterol. While tamoxifen is known to increase the risk of blood clotting in women with cancer, its relationship to stroke risk has been unclear. Because tamoxifen increases the risk of thromboembolism (a blood clot that has traveled from its site of origin to another vessel), its use could be associated with a higher risk of ischemic stroke (arterial obstruction) as compared to hemorrhagic (bleeding) stroke.

Researchers from Duke University Medical Center sought to determine the overall risk of both ischemic stroke and all strokes associated with tamoxifen. They conducted a systematic review of all clinical trials of tamoxifen published since 1980 using MEDLINE.

Nine
'"/>

Contact: Marilee Reu
mreu@aan.com
651-695-2789
American Academy of Neurology
11-Oct-2004


Page: 1 2

Related medicine news :

1. Analysis finds drug improves odds of complete stroke recovery
2. Analysis of study looks at why quitters return to smoking
3. Analysis suggests women treated for breast cancer do better with axillary node dissection
4. Retrospective Statistical Analysis Corroborates Early Results Of Randomized Breast Cancer Trials
5. New U-M Analysis Of Brain At Work
6. Meta-Analysis Of The Efficacy Of Sildenafil (ViagraTM) In The Treatment Of Severe Erectile Dysfunction
7. Digital Speech Analysis Tests Sobriety
8. Common antidepressants lower effects of tamoxifen in many women
9. Study finds women hesitant to take tamoxifen as preventive measure
10. Decision to take tamoxifen difficult for many women
11. Chemotherapy, but not tamoxifen, associated with stroke risk after breast cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Analysis tamoxifen studies reveals slight increase stroke risk

(Date:8/22/2014)... (PRWEB) August 22, 2014 A new, online ... connection. The summit is no-cost and open to everyone. ... kept secrets, practical tips and advice on how to stop ... or manage weight. Mindful eating is not a diet. ... stay motivated instead of an "eat this, don't eat that" ...
(Date:8/22/2014)... who need surgery for facial pain caused by trigeminal ... used, reports a study in the September issue of ... Congress of Neurological Surgeons . The journal is ... part of Wolters Kluwer Health . , Percutaneous ... lower cost than other types of surgical treatments for ...
(Date:8/22/2014)... Ticket Down is a reliable source for ... Albuquerque and Rapid City. For fans looking to speak with ... allows just that. Caputo was born and raised in Hicksville, ... knit family who began to see spirits when she was ... had a chance to do what most people wished they ...
(Date:8/22/2014)... 2014 Pirate Jonny's Caribbean ... in providing new recipe cards, fun t-shirts, and caps ... Hailing from Clearwater, Florida, Pirate Jonny, aka, Jonathan Toner, ... with two to three recipes featuring different flavors of ... on the website. The recipe cards will feature ...
(Date:8/22/2014)... According to the new research ... Global Trends & Forecast to 2019" defines and ... forecast of the market value. The isocyanate material ... 2019, at a significant CAGR from 2014 to ... 44 figures spread through 286 pages and in-depth ...
Breaking Medicine News(10 mins):Health News:20 Top Experts Discuss How to Unravel the Food-Mood Connection 2Health News:More common procedures for painful facial tics carry high costs, reports study in Neurosurgery 2Health News:Theresa Caputo Tickets in Kalamazoo at Wings Stadium, Saenger Theatre in New Orleans, Kiva Auditorium in Albuquerque and Rapid City at Don Barnett Arena Now Available 2Health News:Pirate Jonny's Caribbean BBQ Rubs, Seasonings & Sauces Get New Look by Hoisting New Recipe Card Creations and New Clothing Apparel for its Logos 2Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 2Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 3Health News:Isocyanate Market An Industry Growing Steadily Projected to Grow $38,729 Million by 2019 - Report by MarketsandMarkets 4
(Date:8/21/2014)...  Aptuit LLC announces that Aptuit SSCI, located ... has enhanced its capabilities in the areas of ... molecules, including biologic drugs, metabolites, and polymers, through ... spectrometer. In making the announcement, Dr. ... expanded large molecule capability enhances our early development ...
(Date:8/21/2014)... The spinal column is one of the most ... to and from the brain through the column control many ... or ailment here can be life altering, and leave the ... over their body. Though back injury and disease can have ... more options available to make things better than ever before. ...
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- Inc. ... Inc. for the third straight year, No. 349 ... an exclusive ranking of the nation,s fastest-growing private ... at the most important segment of the economy—America,s ... Dell, Domino,s Pizza, LinkedIn, Zillow, and many other ...
Breaking Medicine Technology:Aptuit SSCI Adds Ultra High Resolution Q-TOF Mass Spectrometer for Large & Small Molecule Analyses 2Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3
Cached News: