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Anesthesia drug may better protect newborn brains during heart surgery

undergo open-heart surgery.

The researchers remain uncertain about the process by which desflurane improved neurologic outcomes in their study, although they speculate that it may decrease the amount and effects of deleterious amino acids in the brain. The current study builds on previous animal research by the Children's Hospital team, which showed neurological benefits to using desflurane during DHCA.

Approximately 40,000 babies are born in the United States every year with cardiovascular defects. About half of these children must undergo open-heart surgery with CPB before their first birthday. Dr. Loepke added that, "If results in humans parallel our results in animal studies, desflurane or similar anesthetics could contribute to clinical improvements for children with heart conditions."


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Contact: John Ascenzi
ascenzi@email.chop.edu
215-590-7332
Children's Hospital of Philadelphia
24-Dec-2002


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