HOME >> MEDICINE >> NEWS
Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life

urring," explained Dr. Ruda. "Abnormal stimulation during these critical developmental time points may abnormally wire the brain."

There has been considerable debate over the existence of pain in newborns and its management. As late as the mid-1980's, surgery was performed on infants without benefit of anesthesia, the belief being that even if babies did experience pain, they would forget about it. Since then, studies of the biological response to pain and the facial expressions of newborns during traumatic procedures document that they do indeed respond to pain. Today, pain from traumatic surgeries in newborns is carefully managed with anesthesia and analgesics.

Scientists have learned that by 24 weeks gestation, very immature pain transmission pathways are already in place. The development of these pathways continues postnatally. What newborns lack are fully developed and functional pain inhibitory systems. These typically develop several weeks after a full-term baby is born.

"Unlike other sensory modalities such as vision and hearing that require the input of sight and sound for their appropriate development, pain pathways normally develop in the absence of, or with little exposure to, painful stimulation. However, medical procedures shortly after birth can expose the nervous system to pain, the developmental effects of which we are just learning," said Dr. Ruda.

In their study, Dr. Ruda and her colleagues used newborn rat pups to explore the effect of tissue injury and pain on the development of pain pathways. An irritant was injected into the left hind paw of the pups to induce swelling. One group received the injection when they were 1 day old, an age equivalent to 24 weeks gestation in humans. A second group received the injection 14 days after birth, equivalent to adolescence in humans. Swelling and redness occurred shortly after the injection and persisted for 5-7 days in both groups.

When the
'"/>

Contact: Jody Dove
jody.dove@nih.gov
301-594-7558
NIH/National Institute of Dental and Craniofacial Research
26-Jul-2000


Page: 1 2 3

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal studies prove hormone replacement therapy improves memory, report Pitt researchers
8. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
9. Animal studies indicate new approach for treating end-stage skin and kidney cancers
10. Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 13, 2017 , ... PurhealthRX , a leading Health and Nutrition Company, ... Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market by ... be easily incorporated into liquid products, while reducing costs to end users. , The ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance ... care insurance companies have a waiver for care if the client has a cognitive ... the family pays for care, is often waived, so the benefits from their insurance ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed a ... and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been ... standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... AMSTERDAM , Sept. 25, 2017   ... Trial Master File solutions, today—from the IQPC Trial ... Amsterdam , NL)—announced that EastHORN Clinical Services ... its clinical programs and TMF management. EastHORN, a ... Montrium,s eTMF platform to increase transparency to enable ...
(Date:9/19/2017)... 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, ... three leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis ... global supply chains, has published the first annual edition of its Global ... more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that ... ... Risk & Performance Index ...
Breaking Medicine Technology:
Cached News: