HOME >> MEDICINE >> NEWS
Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life

urring," explained Dr. Ruda. "Abnormal stimulation during these critical developmental time points may abnormally wire the brain."

There has been considerable debate over the existence of pain in newborns and its management. As late as the mid-1980's, surgery was performed on infants without benefit of anesthesia, the belief being that even if babies did experience pain, they would forget about it. Since then, studies of the biological response to pain and the facial expressions of newborns during traumatic procedures document that they do indeed respond to pain. Today, pain from traumatic surgeries in newborns is carefully managed with anesthesia and analgesics.

Scientists have learned that by 24 weeks gestation, very immature pain transmission pathways are already in place. The development of these pathways continues postnatally. What newborns lack are fully developed and functional pain inhibitory systems. These typically develop several weeks after a full-term baby is born.

"Unlike other sensory modalities such as vision and hearing that require the input of sight and sound for their appropriate development, pain pathways normally develop in the absence of, or with little exposure to, painful stimulation. However, medical procedures shortly after birth can expose the nervous system to pain, the developmental effects of which we are just learning," said Dr. Ruda.

In their study, Dr. Ruda and her colleagues used newborn rat pups to explore the effect of tissue injury and pain on the development of pain pathways. An irritant was injected into the left hind paw of the pups to induce swelling. One group received the injection when they were 1 day old, an age equivalent to 24 weeks gestation in humans. A second group received the injection 14 days after birth, equivalent to adolescence in humans. Swelling and redness occurred shortly after the injection and persisted for 5-7 days in both groups.

When the
'"/>

Contact: Jody Dove
jody.dove@nih.gov
301-594-7558
NIH/National Institute of Dental and Craniofacial Research
26-Jul-2000


Page: 1 2 3

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal studies prove hormone replacement therapy improves memory, report Pitt researchers
8. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
9. Animal studies indicate new approach for treating end-stage skin and kidney cancers
10. Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
(Date:3/4/2015)... 04, 2015 In a small ceremony with ... on their new facility in New Port Richey on February ... new facility will allow the Florida drug detox facility ... drug abuse epidemic through treatment and education. “Due to our ... in the United States, we made the decision that expanding ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 Jeannie Mai, TV ... “The Real” graces the cover of the print publication. Mai ... to choose organic when shopping for clothes and personal care ... opens up about her commitment to an organic diet. She ... energy, not only in gymnastics, but also now as I’m ...
(Date:3/4/2015)... Hoersholm, DK (PRWEB) March 04, 2015 ... of Dako , has joined the Visiopharm ... joins Visiopharm at a time when we are positioned ... quantitative digital pathology for cancer diagnostics and research. ... invested significantly in the development and validation of ONCOtopix™ ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 Problem Gambling ... time to join individuals and organizations across the nation ... general public, health care professionals, policymakers, and others about ... Council on Compulsive Gambling (FCCG) and FCCG partner organizations ... to screen patients for a gambling problem, to make ...
(Date:3/4/2015)... A new dieting routine, called the ... of extending life. Studies conducted by the ... routine can help extend life by increasing anti-oxidant production. ... term benefits, many suffering from obesity are already experiencing ... necessary. As an alternative to the new Feast and ...
Breaking Medicine News(10 mins):Health News:Novus Medical Detox Hosts Ribbon Cutting Ceremony at Pasco County Facility 2Health News:Novus Medical Detox Hosts Ribbon Cutting Ceremony at Pasco County Facility 3Health News:Visiopharm Appoints Patrik Dahlen as Chairman of the Board 2Health News:Visiopharm Appoints Patrik Dahlen as Chairman of the Board 3Health News:Problem Gambling - A Public Health Issue; March Is Problem Gambling Awareness Month 2Health News:Diet Doc Introduces New Alternative to the Feast and Famine Diet 2Health News:Diet Doc Introduces New Alternative to the Feast and Famine Diet 3
(Date:3/3/2015)... DUBLIN , March 3, 2015 Actavis ... it has priced an offering of $21 billion aggregate ... in a registered public offering to be issued by ... by certain of its other subsidiaries (the "Notes"), as ... to PublicFloating Rate Senior Notes* , $500,000,000 ...
(Date:3/3/2015)... Medical Tracking Solutions, Inc., developers of ... Brian Timberlake as Senior Vice President ... build relationships with existing and new clients. Brian brings ... and sales management as well as a deep ... comprehensive inventory management system that provides real-time tracking ...
(Date:3/3/2015)... March 3, 2015 Boston Scientific Corporation (NYSE: ... Dockendorff and Stephen P. MacMillan to its ... of the board, Uwe E. Reinhardt and ... the company,s annual meeting of stockholders in May 2015. ... executive vice president and chief financial officer of Covidien plc. ...
Breaking Medicine Technology:Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 2Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 3Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 4Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 5Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 6Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 7Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 8Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 9Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 10Medical Tracking Solutions, Inc. Hires New SVP, Sales 2Boston Scientific Elects Charles J. Dockendorff And Stephen P. MacMillan To Board Of Directors 2
Cached News: