HOME >> MEDICINE >> NEWS
Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life

urring," explained Dr. Ruda. "Abnormal stimulation during these critical developmental time points may abnormally wire the brain."

There has been considerable debate over the existence of pain in newborns and its management. As late as the mid-1980's, surgery was performed on infants without benefit of anesthesia, the belief being that even if babies did experience pain, they would forget about it. Since then, studies of the biological response to pain and the facial expressions of newborns during traumatic procedures document that they do indeed respond to pain. Today, pain from traumatic surgeries in newborns is carefully managed with anesthesia and analgesics.

Scientists have learned that by 24 weeks gestation, very immature pain transmission pathways are already in place. The development of these pathways continues postnatally. What newborns lack are fully developed and functional pain inhibitory systems. These typically develop several weeks after a full-term baby is born.

"Unlike other sensory modalities such as vision and hearing that require the input of sight and sound for their appropriate development, pain pathways normally develop in the absence of, or with little exposure to, painful stimulation. However, medical procedures shortly after birth can expose the nervous system to pain, the developmental effects of which we are just learning," said Dr. Ruda.

In their study, Dr. Ruda and her colleagues used newborn rat pups to explore the effect of tissue injury and pain on the development of pain pathways. An irritant was injected into the left hind paw of the pups to induce swelling. One group received the injection when they were 1 day old, an age equivalent to 24 weeks gestation in humans. A second group received the injection 14 days after birth, equivalent to adolescence in humans. Swelling and redness occurred shortly after the injection and persisted for 5-7 days in both groups.

When the
'"/>

Contact: Jody Dove
jody.dove@nih.gov
301-594-7558
NIH/National Institute of Dental and Craniofacial Research
26-Jul-2000


Page: 1 2 3

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal studies prove hormone replacement therapy improves memory, report Pitt researchers
8. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
9. Animal studies indicate new approach for treating end-stage skin and kidney cancers
10. Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
(Date:12/20/2014)... York, NY (PRWEB) December 20, 2014 ... that allege a metal-on-metal version of the artificial ... forward in state and federal courts, Bernstein Liebhard ... New Jersey’ Bergen County Superior Court on December ... permitted to begin deposition of plaintiffs on November ...
(Date:12/20/2014)... Recently, VogueQueen.com, a leading wedding dress wholesaler and ... for 2015. Great discounts are now offered on ... can get a discount, up to 80% off, when ... January 30, 2015. , VogueQueen.com has recently released its ... dress promotion. Many customers worldwide like VogueQueen’s special designs ...
(Date:12/20/2014)... New York, New York (PRWEB) December 20, 2014 ... ) continue to move forward in U.S. ... a new study which suggests that children treated ... prolactin, a hormone linked to breast development and ... Psychopharmacology, looked at 34 children and adolescents who ...
(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer (called ... Christmas. In the promotion, all buyers worldwide can enjoy ... something special for the women who are looking for ... new collections of 2015 dresses have been unveiled recently. ... discounted prices. Visit our website now before they are ...
(Date:12/20/2014)... The Twin Cities DI Day is ... the nation! Over 250 financial professionals come together each ... the industry, get motivated to protect their clients and ... and overcoming the challenges of disability. , On September ... came together to attend The 13th Annual Twin Cities ...
Breaking Medicine News(10 mins):Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 4Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3
(Date:12/17/2014)... Revenue and earnings above the previous year - ... In the past 2013/14 fiscal year (ended 30 September ... 4.287 billion (last year: EUR 4.190 billion) despite unfavorable currency ... million. "Overall, 2013/14 was a successful fiscal year for the ... CEO of Carl Zeiss AG. "Thanks to our broad portfolio ...
(Date:12/17/2014)... , The new ... of information concerning the biopharmaceutical Group,s national and international clinical ... to the recently launched institutional website that is receiving accolades ... by a new chapter in the fascinating story of Drug ... and panoramic hub on the world of clinical research, ranging ...
(Date:12/17/2014)... HOUSTON , Dec. 17, 2014 ... Autism Approved ( http://bit.ly/1382OkS ) program seal ... autism community. The program highlights medical practices, materials ... considered "autism-community friendly." Children affected by ... that can be exacerbated by ingredients found in ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3
Cached News: