HOME >> MEDICINE >> NEWS
Animal studies indicate new approach for treating end-stage skin and kidney cancers

New Orleans, La., March 26, 2001 Advanced skin and end-stage kidney cancer patients may have a better chance of survival with drugs developed from a new synthetic enzyme that significantly improves the effectiveness of existing interleukin-2 (IL-2) cancer therapy, based on research presented today at the American Association for Cancer Research 92nd Annual Meeting.

In animal studies conducted by researchers at the Huntsman Cancer Institute in Salt Lake City, UT, and MetaPhore Pharmaceuticals in St. Louis, MO, the synthetic enzyme M40403 showed an ability to reverse the extreme blood-pressure drop that is a common side effect of high-dosage IL-2 cancer therapy. The research also showed that the compound enhances the anti-cancer properties of IL-2 therapy.

IL-2 immunotherapy, which works by activating natural killer (NK) cells that have the ability to recognize and destroy many types of tumors, is an approved treatment for inoperable metastatic melanoma and metastatic renal cell carcinoma. About 80,000 cases of melanoma and renal cell carcinoma are diagnosed in the U.S. each year.

IL-2 use is limited, however, by potentially life threatening side effects, including hypotension, particularly at the high-dosage level indicated for these end-stage cancers. A majority of patients undergoing high-dosage IL-2 treatment currently either require intensive care unit (ICU) intervention and/or are unable to complete the full course of treatment.

Reseachers administered the synthetic enzyme, which mimics the action of a natural enzyme, superoxide dismutase (SOD), as a co-therapy with IL-2 in several animal models of advanced cancer. Previous studies have confirmed that the synthetic enzyme effectively reproduces the free-radical fighting properties of the natural SOD enzyme, which has been found to be deficient in cancer states.

When in excess, free radicals particularly superoxide anions have been shown to deactivate a class of molecules, calle
'"/>

Contact: Punnie Donohue
pdonohue@kupperparker.com
314-290-2014
Kupper Parker Communications
25-Mar-2001


Page: 1 2 3 4

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal studies prove hormone replacement therapy improves memory, report Pitt researchers
8. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
9. Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors
10. Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
(Date:7/29/2015)... ... July 29, 2015 , ... A June 10, 2015 article from the News-Press, ... the importance of having regular skin cancer screenings from an early age. Skin cancer ... rays. When caught early, skin cancer is rarely fatal; however, if left alone for ...
(Date:7/29/2015)... Wis. (PRWEB) , ... July 29, 2015 , ... ... its first two patients in a Clinical Performance Study for the Invisiport at ... 4.4 and 6 French catheter options, offers a less invasive, patient-friendly alternative to ...
(Date:7/29/2015)... MO (PRWEB) , ... July 29, 2015 , ... Attorneys ... the Talcum Powder Cancer Lawsuit Center. The website now features a page dedicated to ... news pieces from other sources. The Talcum Powder Lawsuit News page was ...
(Date:7/29/2015)... ... July 29, 2015 , ... The New Foundation ... which will by the end will cost the 501(c) organization nearly $1 million, will ... anti-ligature requirements. , “We took it down to the studs,” said Geraldine Leary, ...
(Date:7/29/2015)... Charlotte, North Carolina (PRWEB) , ... July 29, ... ... that MetLife, Inc ., a global provider of life insurance, annuities, employee ... Adventure Team Challenge North Carolina inclusive sporting event taking place in Charlotte, ...
Breaking Medicine News(10 mins):Health News:Get Checked for Skin Cancer Early and Often 2Health News:Get Checked for Skin Cancer Early and Often 3Health News:Stealth Therapeutics Inc. Enrolls First Patients in a Clinical Performance Study for the Invisiport Product Line 2Health News:Stealth Therapeutics Inc. Enrolls First Patients in a Clinical Performance Study for the Invisiport Product Line 3Health News:National Attorneys Provide Regular Talcum Powder Lawsuit News Updates 2Health News:National Attorneys Provide Regular Talcum Powder Lawsuit News Updates 3Health News:The New Foundation AZ Renovates Residential Dorms for Youth in Crisis 2Health News:The New Foundation AZ Renovates Residential Dorms for Youth in Crisis 3Health News:MetLife Joins World T.E.A.M. Sports’ Adventure Team Challenge North Carolina as Presenting Sponsor 2Health News:MetLife Joins World T.E.A.M. Sports’ Adventure Team Challenge North Carolina as Presenting Sponsor 3
(Date:7/28/2015)... , July 21, 2015 ... announced the addition of the "Craniomaxillofacial Implants ... Trends and Forecast 2014 - 2022" report ... the craniomaxillofacial implants market studies the current and ... are rapidly gaining popularity in the global market ...
(Date:7/28/2015)... , July 28, 2015 At ... Customer Experience Association recognized 15 winners in the ... as applied across multiple vertical markets. ContextMedia:Health ... Deployment Award for its success with its ... ContextMedia:Health, the leading provider of ...
(Date:7/28/2015)... 28, 2015  Leaf Healthcare releases white paper ... place on the healthcare system . ... modern quality healthcare. Research by the U.S. Department ... Research and Quality shows that pressure ulcers cost ... a year. The condition is both excruciatingly painful ...
Breaking Medicine Technology:Global Craniomaxillofacial Implants (Plate and Screw Fixator Systems, Bone Graft Substitutes, Distraction Systems, and TMJ Replacement Devices) Market Analysis 2014-2022 2ContextMedia:Health Receives Top Award at the ICX Association Excellence Awards 2Impact of Pressure Ulcers on Patient Care: Leaf Healthcare Releases White Paper on the Healthcare Burden of Pressure Ulcers 2Impact of Pressure Ulcers on Patient Care: Leaf Healthcare Releases White Paper on the Healthcare Burden of Pressure Ulcers 3
Cached News: