Animal studies prove hormone replacement therapy improves memory, report Pitt researchers

PITTSBURGH, Nov. 5 For estrogen to enhance learning and memory, nerve cells in the brain called cholinergic neurons are essential to the process, suggest animal studies performed by researchers from the University of Pittsburgh School of Pharmacy and reported in the November issue of Hormones and Behavior, the official journal of the Society for Behavioral Neuroendocrinology.

"Estrogen replacement in postmenopausal women has important effects on mood and cognition. This research was focused on trying to understand what estrogen does in the brain to reduce the effects on brain aging and cognitive decline," stated Robert Gibbs, Pharm.D., associate professor of pharmaceutical sciences at the University of Pittsburgh School of Pharmacy.

In the study, rats had their ovaries removed and some of the animals had specific cholinergic neurons destroyed. A few weeks after surgery, most of the animals were put on estrogen replacement therapy (ERT), while some were not. Four weeks after ERT, the animals were placed several times in a maze to test their memory and performance. Rats that had their ovaries removed with subsequent ERT outperformed rats on various tasks without ERT. The ability of estrogen to enhance performance was lost in animals that had specific cholinergic neurons removed.

"This tells us that the cholinergic neurons are necessary for estrogen to enhance performance in this model," explained Dr. Gibbs.

"We have shown, as in previous studies, that acute and short-term estrogen replacement can significantly enhance the functional status of cholinergic neurons. These results give us hope that estrogen may help to significantly reduce the risk of Alzheimer's-related dementia in postmenopausal women, possibly by affecting these cholinergic neurons," added Dr. Gibbs.

While there have been some studies on the effects of hormone replacement therapy in cognitive decline in postmenopausal women, many experts say further studies n

Contact: Maureen McGaffin
University of Pittsburgh Medical Center

Page: 1 2

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
8. Animal studies indicate new approach for treating end-stage skin and kidney cancers
9. Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors
10. Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
(Date:10/9/2015)... ... 09, 2015 , ... Smoke alarms can save lives. In fact, according to ... dying in reported home fires in half. As part of Fire Prevention Week, ... installed and maintained. , Half of home fire deaths result from fires reported between ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... ... offering a special promotion on Invisalign, the orthodontic system that uses clear, plastic ... aligners are almost invisible against the teeth, which allow patients to complete treatment ...
(Date:10/9/2015)... ... October 09, 2015 , ... Matrix IT Medical Tracking ... for TRACTUS, the world’s first sterile field scanner. , The TRACTUS ... the FDA’s recent Unique Device Identifier (UDI) Final Rule, which will require manufacturers ...
(Date:10/9/2015)... ... October 09, 2015 , ... The Asthma and Allergy Foundation of ... Disease Control and Prevention (CDC) to improve the knowledge and skills of underserved adults ... awarded a project by the CDC and allows AAFA to continue vital efforts to ...
(Date:10/9/2015)... ... October 09, 2015 , ... Cambias Insurance ... surrounding communities, is initiating a combined charity effort with Animal Rescue New Orleans ... southern Louisiana. , Animal Rescue New Orleans is a non-profit organization committed ...
Breaking Medicine News(10 mins):
(Date:10/8/2015)...  Trovagene, Inc., (NASDAQ:   TROV) a developer ... of results from a field experience analysis featuring ... (PCM) platform to accurately identify mutational status, ... appropriate therapy for patients. Mark Erlander , ... the results today in an oral presentation titled ...
(Date:10/8/2015)... 2015 " Biomedical Refrigerators and ... and Forecast 2014 - 2022 " , the biomedical ... in 2013 and is anticipated to expand at a CAGR ... billion in 2022. --> " Biomedical Refrigerators ... Trends and Forecast 2014 - 2022 " , the ...
(Date:10/8/2015)... 2015 http://www.researchandmarkets.com/research/pvzb7x/natural_language ... "Natural Language Processing Market for Health ... (Rule-Based, Statistical, & Hybrid NLP Solutions), Region ... Africa, Latin America) - Global Forecast to ... --> http://www.researchandmarkets.com/research/pvzb7x/natural_language ) has announced the ...
Breaking Medicine Technology:
Cached News: