HOME >> MEDICINE >> NEWS
Animal studies prove hormone replacement therapy improves memory, report Pitt researchers

PITTSBURGH, Nov. 5 For estrogen to enhance learning and memory, nerve cells in the brain called cholinergic neurons are essential to the process, suggest animal studies performed by researchers from the University of Pittsburgh School of Pharmacy and reported in the November issue of Hormones and Behavior, the official journal of the Society for Behavioral Neuroendocrinology.

"Estrogen replacement in postmenopausal women has important effects on mood and cognition. This research was focused on trying to understand what estrogen does in the brain to reduce the effects on brain aging and cognitive decline," stated Robert Gibbs, Pharm.D., associate professor of pharmaceutical sciences at the University of Pittsburgh School of Pharmacy.

In the study, rats had their ovaries removed and some of the animals had specific cholinergic neurons destroyed. A few weeks after surgery, most of the animals were put on estrogen replacement therapy (ERT), while some were not. Four weeks after ERT, the animals were placed several times in a maze to test their memory and performance. Rats that had their ovaries removed with subsequent ERT outperformed rats on various tasks without ERT. The ability of estrogen to enhance performance was lost in animals that had specific cholinergic neurons removed.

"This tells us that the cholinergic neurons are necessary for estrogen to enhance performance in this model," explained Dr. Gibbs.

"We have shown, as in previous studies, that acute and short-term estrogen replacement can significantly enhance the functional status of cholinergic neurons. These results give us hope that estrogen may help to significantly reduce the risk of Alzheimer's-related dementia in postmenopausal women, possibly by affecting these cholinergic neurons," added Dr. Gibbs.

While there have been some studies on the effects of hormone replacement therapy in cognitive decline in postmenopausal women, many experts say further studies n
'"/>

Contact: Maureen McGaffin
412-647-3555
University of Pittsburgh Medical Center
5-Nov-2002


Page: 1 2

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
8. Animal studies indicate new approach for treating end-stage skin and kidney cancers
9. Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors
10. Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
(Date:8/31/2015)... ... August 31, 2015 , ... Wyoming Medical Center, an ... for its Clinical Documentation Improvement (CDI) and medical coding needs. Based on a ... - ezCAC is an enterprise-level coding solution that combines CDI, Coding, Quality and ...
(Date:8/31/2015)... ... ... The more hours young adults spend watching television each day, the greater ... a 15-year analysis by the University of Pittsburgh Graduate School of Public Health revealed. ... adulthood is an important time to intervene and promote less television viewing, according to ...
(Date:8/31/2015)... ... August 31, 2015 , ... People ... at a greater risk for injury, potentially because they are more susceptible to ... Graduate School of Public Health analysis discovered. , The research, published online ...
(Date:8/31/2015)... ... August 31, 2015 , ... With baseball season in full ... World Series will dominate the sports world. Fans desire nothing more than to see ... final series. For children, especially those who are too young to really understand what ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... to develop skills and assess their competencies in managing challenging conversations, announced today ... at the Defense Centers of Excellence for Psychological Health and Traumatic Brain ...
Breaking Medicine News(10 mins):Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 3Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 4Health News:Watching More TV as a Young Adult Predicts Obesity 2Health News:Watching More TV as a Young Adult Predicts Obesity 3Health News:Television Viewing Linked to Higher Injury Risk in Hostile People 2Health News:Television Viewing Linked to Higher Injury Risk in Hostile People 3Health News:New Children's Baseball Series Offers Young Fans a Way to Celebrate the World Series 2Health News:Kognito’s Glenn Albright to Present at DCoE Summit 2
(Date:8/31/2015)... 31, 2015  Dipexium Pharmaceuticals, Inc. (NASDAQ: DPRX ... and commercialization of Locilex® (pexiganan cream 0.8%), a novel, ... participate in four investor conferences in September. ... Sidoti & Company, LLC Emerging Growth Conference in ... P. Luci , President & Chief Executive Officer, will ...
(Date:8/31/2015)... 2015 Regen BioPharma, Inc. (OTCBB: RGBP) ... novel means of delivering its patented (US Patent ... tumors utilizing a clinically approved formulation as delivery ... with gene silencing therapeutics in which the gene ... whole body.  By utilizing a local delivery system, ...
(Date:8/31/2015)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ), the nation,s largest ... Chairman & CEO, and Sean Whelan , CFO, will ... Hagerman and Mr. Whelan are scheduled to participate in the ... on Wednesday, September 9, 2015 at 1:45 PM ET. ... to participate in the Robert W. Baird 2015 Healthcare Conference ...
Breaking Medicine Technology:Dipexium Pharmaceuticals Announces Participation in Four Investor Conferences in September 2Dipexium Pharmaceuticals Announces Participation in Four Investor Conferences in September 3Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3Diplomat to Participate in Upcoming Investor Conferences 2
Cached News: