HOME >> MEDICINE >> NEWS
Animal studies prove hormone replacement therapy improves memory, report Pitt researchers

PITTSBURGH, Nov. 5 For estrogen to enhance learning and memory, nerve cells in the brain called cholinergic neurons are essential to the process, suggest animal studies performed by researchers from the University of Pittsburgh School of Pharmacy and reported in the November issue of Hormones and Behavior, the official journal of the Society for Behavioral Neuroendocrinology.

"Estrogen replacement in postmenopausal women has important effects on mood and cognition. This research was focused on trying to understand what estrogen does in the brain to reduce the effects on brain aging and cognitive decline," stated Robert Gibbs, Pharm.D., associate professor of pharmaceutical sciences at the University of Pittsburgh School of Pharmacy.

In the study, rats had their ovaries removed and some of the animals had specific cholinergic neurons destroyed. A few weeks after surgery, most of the animals were put on estrogen replacement therapy (ERT), while some were not. Four weeks after ERT, the animals were placed several times in a maze to test their memory and performance. Rats that had their ovaries removed with subsequent ERT outperformed rats on various tasks without ERT. The ability of estrogen to enhance performance was lost in animals that had specific cholinergic neurons removed.

"This tells us that the cholinergic neurons are necessary for estrogen to enhance performance in this model," explained Dr. Gibbs.

"We have shown, as in previous studies, that acute and short-term estrogen replacement can significantly enhance the functional status of cholinergic neurons. These results give us hope that estrogen may help to significantly reduce the risk of Alzheimer's-related dementia in postmenopausal women, possibly by affecting these cholinergic neurons," added Dr. Gibbs.

While there have been some studies on the effects of hormone replacement therapy in cognitive decline in postmenopausal women, many experts say further studies n
'"/>

Contact: Maureen McGaffin
412-647-3555
University of Pittsburgh Medical Center
5-Nov-2002


Page: 1 2

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
8. Animal studies indicate new approach for treating end-stage skin and kidney cancers
9. Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors
10. Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
(Date:11/23/2014)... 2014 (HealthDay News) -- Close friends have more influence ... does, a new study says. "We,ve known ... an influence on individual alcohol use, but there are ... group and the friend group,s influence on those decisions," ... of Public Health, said in a university news release. ...
(Date:11/23/2014)... high quality access control power suppliers are popular in ... new collection of power suppliers. Additionally, it has launched ... All the new models come with big discounts, up ... 20, 2014. , SWAccessControl.com has thousands of happy customers, ... a long time. It is very wise to visit ...
(Date:11/23/2014)... The FDA is Watching: , What ... Webinar**, Dec. 11, 2014 ? Any Time at Your ... on promotional activities is no longer limited to magazine ... at websites, Twitter, journal articles, TV appearances, Facebook and ... 11, for On-Demand access to Timothy Ayers and Michelle ...
(Date:11/22/2014)... 23, 2014 Every year AlignLife clinics ... AlignLife experience rapid growth in the Greenville, SC area ... opportunity. AlignLife of Simpsonville will be partnering ... their first annual Toy Drive. These six offices came ... support with this year's toy drive. With so many ...
(Date:11/22/2014)... 2014 A classic black prom dress will ... famous dress suppliers, has unveiled its new items of black ... now offered at a big discount, up to 70% off. ... , The new black prom dresses, made with the best ... the needs of all customers, the company provides these beautiful ...
Breaking Medicine News(10 mins):Health News:Close Friends May Be Key to Teens' Drinking 2Health News:Cheap Access Control Power Supplies Online Now at SWAccessControl.com, Special Offer Until Dec. 20, 2014 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 3Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 4Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 5Health News:Greenville Area AlignLife Offices Join Together for a Local Toy Drive 2Health News:New Black Prom Dresses from BellasDress.com 2
(Date:11/21/2014)... research firm Kalorama information says that 2014 will be ... medical device industry.  The firm thinks the $360 billion-dollar ... growth this year, which led firms to look to ... entrance by acquisition into new competitive zones.  The company ... Global Market for Medical Devices, 5 th Edition ...
(Date:11/21/2014)... , 21. November 2014 Michael ... sich am Morgen des 14. Februar 2014 zugetragen hat. ... wohl kaum vergessen. Video - http://youtu.be/5cVoMCe0uiE ... ich dabei war, mein morgendliches Training zu machen", erzählt ... zu der Zeit begeisterte Anhänger der CrossFit-Trainingsmethode. ...
(Date:11/21/2014)... Nov. 21, 2014  Lexicon Pharmaceuticals, Inc. (Nasdaq: ... previously announced underwritten public offering of $50,000,000 of shares ... registration statement. The offering will consist of 49,751,244 shares ... $1.005 per share.  Lexicon has also granted the underwriters ... shares of common stock.  All of the shares in ...
Breaking Medicine Technology:Kalorama: 2014 The "Year of The Buy" in Medical Device Industry 2Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 2Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 3Lexicon Announces Pricing Of Common Stock Offering 2Lexicon Announces Pricing Of Common Stock Offering 3
Cached News: