HOME >> MEDICINE >> NEWS
Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors

A tiny fat-based spherical structure called a liposome, modified at Duke to be sensitive to mild heating, can triple the amount of an anti-cancer drug delivered to tumors in mice compared to other liposome-based drug-delivery methods, Duke Medical Center researchers reported Thursday.

"Earlier this year we saw an improved therapeutic effect in animals, but didn't know exactly why," said Garheng Kong, lead author of the new study findings published in the Dec. 15 issue of Cancer Research. "Now we've shown that it's due to increasing the concentration of the drug in the tumor compared to the other treatments tested."

Because delivering anti-cancer drugs into tumors is one of the major hurdles in advancing potential drugs from the cell culture dish to clinical trials, this discovery could pave the way to improve the success of chemotherapy in humans, the researchers said.

"There are countless drugs that are very effective at killing cancer cells in the laboratory, but they act very differently in a living system many just won't go where you want them to go," said principal investigator Mark Dewhirst, director of Duke Comprehensive Cancer Center's Hyperthermia Program. "We're able to see an enhanced anti-tumor effect in mice with this new liposome because we're getting more drug into the tumor. This new liposome may eventually be applicable in cases where traditional chemotherapy is not effective."

While human studies are more than a year away, the results of the scientists' studies in mice differentiate the therapeutic importance of heat, liposomes and drug release and the interaction of these factors by measuring amounts of the chemotherapy drug doxorubicin delivered to tumors by 10 different treatments. The study was funded by the National Institutes of Health, the Department of Defense, an NIH Medical Scientist Training Grant and Celsion Corp., Columbia, Md.

Drugs enclosed in standard liposomes, which aren't sensitive to temperatu
'"/>

Contact: Joanna Downer
downe010@mc.duke.edu
919-684-4148
Duke University Medical Center
13-Dec-2000


Page: 1 2 3 4

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal studies prove hormone replacement therapy improves memory, report Pitt researchers
8. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
9. Animal studies indicate new approach for treating end-stage skin and kidney cancers
10. Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... Walton Beach, Florida (PRWEB) , ... May 31, ... ... technology to Jay Butch of CertainTeed Corporation, he knew it was something that ... is as state-of-the-art and cutting-edge as it gets,” says Butch, CertainTeed’s Director of ...
(Date:5/31/2016)... ... ... The successful implementation of “lean manufacturing” in various fields has inspired many businesses ... compared to manufacturing environments. , In order to provide a way to gain ... Lean Lab Checklist . This checklist will help users gain an overview of ...
(Date:5/31/2016)... ... May 31, 2016 , ... Spectrum Aquatics has launched a brand new ... designed and built with the user in mind. , “Over the last two years ... that an ADA 400 lbs lift is a necessary requirement for certain facilities with ...
(Date:5/31/2016)... ... , ... In a recent interview on The Greenburgh Report radio show hosted ... WVOX (1460 AM), leading medical insurance advocate Adria Goldman Gross discussed several eye-opening ... maelstrom.” , During the interview with Mr. Feiner that aired on May 7, ...
(Date:5/31/2016)... PLAINSBORO, N.J. (PRWEB) , ... May 31, 2016 ... ... digital and print media enterprise focused on patients with cancer, has added ... provide readers and website visitors with more timely content on continuing successful careers ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... York , May 31, 2016 ... biomaterials market is progressing at a CAGR of 10.6% ... market was valued at US$0.46 bn in 2013. Owing ... is expected to reach US$0.88 bn by the end ... is derived from the market,s holistic representation in a ...
(Date:5/31/2016)... VALLEY COTTAGE, New York , May 31, 2016 ... traction as an essential ingredient in food, cosmetics and ... 2016 end, representing revenues worth US$ 1.6 Bn. ... vera gels, cosmetics products, juices, and yogurts will continue ... health and wellness trend will also boost positive sentiment ...
(Date:5/31/2016)... The global biomaterials market is driven ... of deaths from chronic diseases. According to research report, "Global ... Opportunities and Forecasts (2016-2021) - (By Value; By Material Type ... Wound Care); By Region-North America, Europe , ... , Italy , Japan ...
Breaking Medicine Technology:
Cached News: