HOME >> MEDICINE >> NEWS
Animal study show that heat-sensitive liposome improves chemotherapy delivery to tumors

A tiny fat-based spherical structure called a liposome, modified at Duke to be sensitive to mild heating, can triple the amount of an anti-cancer drug delivered to tumors in mice compared to other liposome-based drug-delivery methods, Duke Medical Center researchers reported Thursday.

"Earlier this year we saw an improved therapeutic effect in animals, but didn't know exactly why," said Garheng Kong, lead author of the new study findings published in the Dec. 15 issue of Cancer Research. "Now we've shown that it's due to increasing the concentration of the drug in the tumor compared to the other treatments tested."

Because delivering anti-cancer drugs into tumors is one of the major hurdles in advancing potential drugs from the cell culture dish to clinical trials, this discovery could pave the way to improve the success of chemotherapy in humans, the researchers said.

"There are countless drugs that are very effective at killing cancer cells in the laboratory, but they act very differently in a living system many just won't go where you want them to go," said principal investigator Mark Dewhirst, director of Duke Comprehensive Cancer Center's Hyperthermia Program. "We're able to see an enhanced anti-tumor effect in mice with this new liposome because we're getting more drug into the tumor. This new liposome may eventually be applicable in cases where traditional chemotherapy is not effective."

While human studies are more than a year away, the results of the scientists' studies in mice differentiate the therapeutic importance of heat, liposomes and drug release and the interaction of these factors by measuring amounts of the chemotherapy drug doxorubicin delivered to tumors by 10 different treatments. The study was funded by the National Institutes of Health, the Department of Defense, an NIH Medical Scientist Training Grant and Celsion Corp., Columbia, Md.

Drugs enclosed in standard liposomes, which aren't sensitive to temperatu
'"/>

Contact: Joanna Downer
downe010@mc.duke.edu
919-684-4148
Duke University Medical Center
13-Dec-2000


Page: 1 2 3 4

Related medicine news :

1. Animal study shows link between nicotine and atrial flutter
2. Animal studies show stem cells might make biological pacemaker
3. Animal study suggests safer immunization approach to Alzheimers
4. Animal model, new grant, propel UB researchers forward in search for tinnitus treatment
5. Animal model shows early promise for SARS vaccine
6. Understanding Alzheimers disease: Animal research points to new direction for therapy
7. Animal studies prove hormone replacement therapy improves memory, report Pitt researchers
8. Animal-based nutrients linked with higher risk of stomach and esophageal cancers
9. Animal studies indicate new approach for treating end-stage skin and kidney cancers
10. Animal model shows pain and tissue injury in newborns alters nerve circuitry and reaction to pain later in life
11. AVANT Atherosclerosis Vaccine Raises HDL, Reduces Atherosclerosis In Vaccinated Animals

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to improve their ... The patient is doing more than filling out a survey; in many cases health ... increasing emphasis in health care and research on the importance of active engagement with ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health ... technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing ... form that can be easily incorporated into liquid products, while reducing costs to end ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released a ... books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture of ... have tossed it off as mere rubbish, but Yisrayl Hawkins says that is because ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
(Date:9/19/2017)... HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform ... leadership team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led ...
Breaking Medicine Technology:
Cached News: