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Antabuse May Inhibit Fatal Reaction To Anesthetic

major component in Tylenol, for instance, is also metabolized by the P450 2E1 enzyme. Inhibiting it may allow physicians to prevent liver damage in overdose cases. Kharasch said he is currently investigating this possibility in studies with Dr. John Slattery, professor of pharmaceutics and a member at Fred Hutchinson Cancer Research Center.

The knowledge researchers have gained in their work on halothane may also enable them to manipulate P450 2E1 to prevent damage to organs in workers who have been exposed to Freon, or other hazardous chemicals, in industrial accidents. "With further work, we could recommend disulfiram as a treatment for people exposed to carcinogens, or in other situations where we want to intercept the process of metabolism," Kharasch said.


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Contact: Will Morton
wmmorton@u.washington.edu
206-543-3620
University of Washington
3-Dec-1998


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