HOME >> MEDICINE >> NEWS
Anti-cocaine vaccine produces antibodies and is shown to be safe in Phase 1 study conducted by Yale researcher

A therapeutic cocaine vaccine designed to suppress the high addicts get from taking cocaine is safe and produced cocaine antibodies in humans, a Yale study finds.

Thomas Kosten, M.D., principal investigator on the phase 1 study, and his team administered the vaccine to 34 former cocaine abusers living in a residential treatment facility.

The vaccine, TA-CD, is designed to generate drug-specific antibodies, which bind to cocaine and prevent it from traveling to the brain from the bloodstream. This neutralizes its psychoactive effect.

"The vaccine is very safe and we did not observe any major side effects," said Kosten, professor of psychiatry at Yale School of Medicine. "TA-CD was effective in producing cocaine-specific antibodies, which lasted throughout the trial. More advanced trials are already underway. TA-CD offers the potential for a completely new and highly viable approach to a very serious problem for which there are no alternative therapies available."

Such a product, Kosten said, would be complementary to behavioral therapy in overcoming cocaine addiction. This vaccine would target the more than two million regular cocaine users in the United States alone. Of these, 900,000 seek treatment each year.

In the Phase 1 trial, the vaccine was given to 34 subjects split into three cohorts to evaluate three different doses of the vaccine following 30 days of abstinence. Two subjects in each cohort received a placebo and the rest received active vaccine. The studys participants had to meet the criteria for cocaine dependence, including a three- to 10-year cocaine habit, and willingness to get treatment and participate in the study.

The people in the study, Kosten said, had a motivation to want to stop using cocaine. This desire to stop is the key factor of any successful treatment outcome.

The vaccine does not take away the desire or the craving for cocaine, Kosten said, but the antibodies it generates block the priming effe
'"/>

Contact: Karen Peart
karen.peart@yale.edu
203-432-1326
Yale University
6-Mar-2000


Page: 1 2

Related medicine news :

1. Pitt marks 50th anniversary of its Salk polio vaccine with reunion, scientific symposium
2. NIAID initiates trial of experimental avian flu vaccine
3. Study finds majority of women willing to accept cervical cancer vaccine for self and children
4. Invasive pneumonia and antibiotic resistance decreased after childhood vaccine introduced
5. Earlier use of prostate cancer vaccines urged by Hopkins scientists
6. Researchers close in on breast cancer vaccine
7. EuroVacc 02 HIV vaccine trial begins in February 2005
8. Varicella vaccine effective on chicken pox; Impact on herpes zoster unclear
9. Pathogen-mimicking vaccine as strategy for cancer therapy
10. HIV vaccine trial breaks ground for future research
11. First US kidney cancer vaccine trial underway at Columbia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/19/2019)... FORT WASHINGTON, Pa. (PRWEB) , ... July 19, ... ... cardiovascular disease medical education, announces the hiring of Megan Clem as Senior Director ... pharmaceutical, medical device, and education sectors. , “Having worked globally with physician experts ...
(Date:7/18/2019)... (PRWEB) , ... July 18, 2019 , ... ... on addressing unmet needs in the field of urology, today announced that Garrett ... Center of Excellence. The designation recognizes that Dr. Matsunaga has achieved a high ...
(Date:7/18/2019)... Fla. (PRWEB) , ... July 18, 2019 , ... Dr. ... recent scientific studies in order to accurately address concerns brought to him by his ... of dental floss has been brought to his attention by patients in his Clearwater, ...
(Date:7/17/2019)... (PRWEB) , ... July 17, 2019 , ... ... device, the first that is capable of treating up to eight body areas ... perform total body muscle toning much faster and easier than previous muscle toning devices ...
(Date:7/17/2019)... ... 2019 , ... The Blackboard Catalyst Award in Teaching and ... honor is given to distance learning courses and programs that help set the ... from around the world that produce exemplary educational and training opportunities. Winners in ...
Breaking Medicine News(10 mins):
(Date:7/17/2019)... ... , ... Argos Risk, an industry leader of Third-Party Risk ... the second quarter of 2019. Three nationwide companies, whose primary focus is providing ... list in managing and mitigating third-party risk. , “We are excited to welcome ...
(Date:7/17/2019)... ... 16, 2019 , ... For the fifth consecutive year, ... excellence in healthcare-professional marketing and media. This year, ReachMD is a finalist in ... (3) Best Young Marketer , The MM&M Awards honor the best in healthcare ...
(Date:7/17/2019)... ... July 17, 2019 , ... Women’s Excellence is pleased to offer ... NFP is a method of birth regulation that is consistent with Catholic marriage ... To avoid pregnancy, the couple abstains from all sexual contact during the fertile time. ...
Breaking Medicine Technology:
Cached News: