HOME >> MEDICINE >> NEWS
Anti-depressants used during pregnancy linked to neonatal withdrawal syndrome

Babies exposed to anti-depressants called Selective Serotonin Reuptake Inhibitors (SSRIs) in the womb may be born with withdrawal syndrome, suggests a study published in this week's issue of THE LANCET. The authors of the study conclude that doctors should avoid or cautiously manage the prescribing of these drugs to pregnant women with psychiatric disorders.

SSRIs were introduced in 1988 and are becoming the gold standard treatment for depression and a wide spectrum of other mood and behavioural disorders. The presence of a withdrawal reaction to SSRIs is now widely recognised and several cases of neonatal withdrawal syndrome associated with the drugs - characterised by convulsions, irritability, abnormal crying and tremor- have been reported.

Emilio Sanz (University of La Laguna, Spain) and colleagues screened the WHO database of adverse drug reactions for cases of neonatal convulsions and neonatal withdrawal syndrome associated with the use of SSRIs. The database contains information from 72 countries and holds over 3 million records dating from 1968. Use of other medications and symptoms were carefully reviewed in the original reports to rule out alternative causes of withdrawal syndrome.

The investigators found that by November 2003, a total of 93 cases of SSRI use associated with either neonatal convulsions or withdrawal syndrome had been reported, suggesting a possible causal relationship. Of these cases 64 were associated with paroxetine, 14 with fluoxetine, nine with sertraline and seven with citalopram.

The dose was only reported in 13 cases associated with paroxetine and ranged from 10mg to 50mg per day. The duration of treatment was reported only in eight cases, and in all of them the drug was used for 4 to 60 months before delivery and stopped at delivery.

Professor Sanz concludes: "Within the limits of spontaneous reports on these drugs, the results suggest that symptoms of withdrawal might be a greater proble
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
3-Feb-2005


Page: 1 2

Related medicine news :

1. New study in Nature demonstrates protection against cell death during heart attack
2. Acupuncture relieves pelvic pain during pregnancy
3. Neurobehavioral function during coma, stroke rehabilitation effective for elderly
4. Northwestern Memorial physicians encourage screenings during colon cancer awareness month
5. Columbia study shows widely used artery clearing device does not help patients during heart attack
6. Researchers model brains electrical storm during a seizure
7. Brain activity of men and women during hostile or impulsive acts differs less on nicotine
8. Abnormal brain activity during the observation of others actions
9. Study reports women dont experience undue pain, anxiety during mammography screening
10. How women can avoid migraines during that time-of-the-month
11. Assessing the season: LSU hurricane experts learned lessons during Hurricane Season 2004

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/20/2017)... ... ... Are you an adult with gluten intolerance or Celiac disease living with another ... in a research study that focuses on family interactions when dealing with dietary restrictions. ... of adults who have gluten sensitivities who cohabitate with other adults who may or ...
(Date:8/19/2017)... ... August 19, 2017 , ... The digital health and ... with pending recognition status from the Centers for Disease Control and Prevention (“CDC”) ... and live video conferencing. , The DPP resulted from clinical work conducted ...
(Date:8/19/2017)... ... August 19, 2017 , ... Physician Partners of ... location as an interventional pain management physician. He brings a wealth of pain ... migraine headaches, and significant experience in spinal cord stimulation for chronic pain. , ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... LLC (“Quick”), a highly specialized asset-light logistics provider of complex transport solutions ... definitive agreement to purchase Unitrans International Corporation, a division of Roadrunner Transportation ...
(Date:8/18/2017)... O'Fallon, MO (PRWEB) , ... August 18, 2017 , ... ... Charles County, is inaugurating a new charity drive to generate community support for efforts ... for research into cures and treatments for all types of cancer. , Each ...
Breaking Medicine News(10 mins):
(Date:7/28/2017)... Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today announced financial ... 2017, and updated its financial outlook for fiscal 2017. ... fiscal third quarter, Hill-Rom reported earnings of $0.09 per ... the prior-year period. These results reflect after-tax special items, ... related to the non-cash write-down of assets associated with ...
(Date:7/27/2017)... Holdings, Inc. (NYSE and SIX: ZBH) today reported financial results ... reported second quarter net sales of $1.954 billion, an ... an increase of 2.1% on a constant currency basis.  ... LDR Holding Corporation acquisition, second quarter 2017 revenues decreased ... on a constant currency basis. ...
(Date:7/26/2017)... 26, 2017 E.I. Medical Imaging (EIMI) has ... SharkLab to custom design the worlds first ultrasound system to be ... their native habitat. In preparation for a piece produced by ... Shark Week, Dr. Guttridge approached EIMI with the idea of ... to hammerhead sharks underwater. ...
Breaking Medicine Technology:
Cached News: