Anti-eosinophil therapy shown to be effective in treating hypereosinophilic syndrome

Anti-eosinophil therapy is a safe and effective way to treat patients with hypereosinophilic syndromes, according to new research published in the January 2004 Journal of Allergy and Clinical Immunology (JACI). The JACI is the peer-reviewed scientific journal of the American Academy of Allergy, Asthma and Immunology (AAAAI).

Hypereosinophilic syndromes are a group of disorders characterized by excessive numbers of eosinophils, a type of white blood cell, which accumulate in the blood. An increase in eosinophils is most commonly caused by an allergic reaction, resulting in the use of steroids to decrease their over-production.

However, in hypereosinophilic syndromes, eosinophils multiply in an uncontrolled manner, attacking numerous parts of the body, including the heart, lungs, gastrointestinal tract, and skin. Treatment usually involves the use of potentially toxic medications to stop the overproduction of eosinophils. However, current treatments only provide limited control and quickly become ineffective.

A research team led by Marc E. Rothenberg, MD, PhD, Cincinnati Children's Hospital Medical Center, is the first to report on the safety and efficacy of a new anti-IL-5 therapy in patients with severe forms of hypereosinophilic syndromes. Originally developed for the treatment of asthma, anti-IL-5 therapy blocks the eosinophil growth factor interleukin-5 (IL-5). IL-5 is a cytokine critically involved in regulating several aspects of eosinophils including their production, activation and tissue recruitment.

Four patients, previously dependent on a variety of toxic medications to partially treat their hypereosinophilic syndrome, were given three intravenous doses of anti-IL-5 administered at four week intervals. Researchers found that anti-IL-5 was well tolerated in all four patients and lowered eosinophil counts despite on-going systemic steroid therapy. This decline in eosinophil counts was sustained for at least 12 weeks aft

Contact: John Gardner
American Academy of Allergy, Asthma & Immunology

Page: 1 2

Related medicine news :

1. Study shows patch therapy may be as effective as oral medications
2. Novel therapy tested in mice could chase away cat allergies
3. Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack
4. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
5. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
6. Bevacizumab combined with chemotherapy prolongs survival for some patients with advanced lung cancer
7. Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
8. Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit
9. Combining PET and CT scans leads to more accurate radiation therapy for lung cancer patients
10. Cognitive behavioral therapy and medication is effective in the treatment of panic disorder
11. Study finds drug eluting stents as effective as vascular brachytherapy in preventing restenosis

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... ... PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor ... prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. The ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... IRVING, Texas , Oct. 11, 2017  Caris ... science focused on fulfilling the promise of precision medicine, ... Institute has joined Caris, Precision Oncology Alliance™ (POA) as ... leading cancer centers, the St. Jude Crosson Cancer Institute ... to advance the use of tumor profiling, making cancer ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
Breaking Medicine Technology:
Cached News: