HOME >> MEDICINE >> NEWS
Antibiotic provides promise in treatment of spinal cord injuries

Researchers at Brigham and Women's Hospital (BWH) and Children's Hospital Boston (CHB) have found that a commonly prescribed antibiotic could be used to help prevent paralysis and other long-term functional deficits associated with a partial spinal cord injury (SCI). Researchers in the field have known that a significant proportion of paralysis and long-term functional disorders associated with SCI are triggered by post-trauma tissue loss. Administering the antibiotic, minocycline, to rats within the first hour after a paralyzing injury has been shown to reduce this tissue loss and ultimately enable more hind-leg function, the ability to walk with more coordination, better foot posture and stepping, and better support of body weight than untreated controls. The findings are published in the March 2, 2004 issue of the Proceedings of the National Academy of Sciences.

The BWH/CHB researchers found that minocycline reduces later-stage tissue loss by blocking release of a protein known as mitochondrial cytochrome c. Yang D. Teng, MD, PhD, of the joint BWH/CHB neurosurgery program and co-lead author of the study, notes that other experimental agents can prevent later-stage tissue loss, but must be given immediately after or even before SCI to be effective. "The field has badly needed to develop a drug that could be used in a practical manner," said Teng.

According to the National Spinal Cord Injury Association, approximately 250,000 to 400,000 individuals in the United States currently have spinal cord injuries with more than 11,000 individuals each year impacted by a spinal cord injury. Ninety percent of these injuries are partial meaning that the spinal cord is damaged but not severed, as in the current study.

"These research results are exciting in that they demonstrate a novel post-trauma strategy in the form of a safe, FDA-approved drug that could serve as a prototype drug for developing better therapeutic strategies to improve quality of life for p
'"/>

Contact: Susan Craig
susan.craig@childrens.harvard.edu
617-355-8834
Children's Hospital Boston
24-Feb-2004


Page: 1 2

Related medicine news :

1. Antibiotics protect nerves in mice by turning on genes
2. Antibiotic rifampicin shows promise for fighting Parkinsons disease in lab tests
3. Antibiotics within 4 hours of arrival at hospital better for pneumonia patients
4. Antibiotic resistant bacteria frequently transmitted between intensive care patients
5. Antibiotic use on swine farms increases efficiency, profits
6. Antibiotic slows atherosclerosis in people with Chlamydia pneumonia antibodies
7. Antibiotics not always beneficial for childhood ear infections
8. Antibiotic could offer promise for treatment of cystic fibrosis
9. Antibiotics help heart patients
10. Antibiotic prescription patterns violate guidelines, increase costs
11. Antibiotic prescribing in local communities is linked to localised resistance

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... (PRWEB) , ... September 17, 2019 , ... ... to join the largest accountable care organization (ACO) in the country, the company ... this groundbreaking collaboration to improve care quality and increase cost efficiency. This opportunity ...
(Date:9/17/2019)... ... 17, 2019 , ... Dr. Perry Patel, the dentist ... the American Academy of Facial Esthetics (AAFE) to administer Botox and dermal filler ... conditions such as tooth clenching and grinding, tongue tension, temporomandibular joint disorders, commonly ...
(Date:9/17/2019)... ... September 17, 2019 , ... The Center for Information ... of the third edition of The Gift of Participation. Written by CISCRP Founder, ... families to navigate the clinical research process. The new edition offers a fresh ...
(Date:9/14/2019)... (PRWEB) , ... September 13, ... ... Society (WMIS) showcased several first-in-human studies on the detection and treatment of ... two examples of these ground-breaking studies were noninvasive detection of residual HIV ...
(Date:9/11/2019)... ... September 12, 2019 , ... “Heart Seizures”: a useful ... coronary artery disease as he hopes to prevent anyone from having it and to ... author John Saltwick, a writer who was diagnosed with coronary artery disease. Predicted to ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... Ill. (PRWEB) , ... September 17, 2019 , ... ... Illinois has joined the esteemed Haute Beauty network. , The Haute Beauty Network, ... to present Dr. Babis Rammos as a body expert and our newest addition ...
(Date:9/14/2019)... ... September 13, 2019 , ... Braun Industries, Crestline Coach Ltd, and ... service and wish him well on his retirement. Braun Industries and Crestline Coach invite ... contact them direct for inquires related to new ambulance sales and service. , ...
(Date:9/14/2019)... ... September 14, 2019 , ... ... plaintiffs living with peritoneal mesothelioma, a jury in Middlesex County found Johnson & ... of plaintiffs alleging their mesotheliomas were caused by asbestos-containing J&J talc products. ...
Breaking Medicine Technology:
Cached News: