HOME >> MEDICINE >> NEWS
Antibiotic rifampicin shows promise for fighting Parkinson's disease in lab tests

SANTA CRUZ, CA--Researchers at the University of California, Santa Cruz, have shown that rifampicin, an antibiotic used to treat leprosy and tuberculosis, can prevent the formation of protein fibrils associated with the death of brain cells in people with Parkinson's disease. The drug also dissolved existing fibrils in laboratory tests.

The researchers studied the effects of rifampicin in test tube experiments and are currently doing studies with cell cultures and mice to see if the same effects occur in living cells. Although these are just the first steps along the path toward clinical studies in humans, the findings suggest that rifampicin and related compounds might be effective in preventing fibril formation and associated neurological damage in patients with Parkinson's disease, said Anthony Fink, professor of chemistry and biochemistry at UCSC.

"Clearly, more work is needed to determine if this would work therapeutically, but if it does it would probably be most useful as a prophylactic therapy used in the early stages of the disease before there is general neurological damage," Fink said.

The research was carried out by a team of scientists in Fink's lab, including postdoctoral researchers Jie Li, Min Zhu, and Sudha Rajamani and research associate Vladimir Uversky. Li is first author of a paper describing their results in the November issue of the journal Chemistry and Biology, which is mailed and published online on November 29.

Aggregation of the protein known as alpha-synuclein into insoluble fibrils is thought to be a critical step in the development of Parkinson's disease, a progressive movement disorder resulting from the death of nerve cells in the brain that produce the neurotransmitter dopamine. Deposits called Lewy bodies, composed mostly of alpha-synuclein fibrils, appear in affected nerve cells, but the connection between the fibrils and cell death remains controversial, Fink said.

"There are t
'"/>

Contact: Tim Stephens
stephens@ucsc.edu
831-459-4352
University of California - Santa Cruz
29-Nov-2004


Page: 1 2 3

Related medicine news :

1. Antibiotics protect nerves in mice by turning on genes
2. Antibiotics within 4 hours of arrival at hospital better for pneumonia patients
3. Antibiotic provides promise in treatment of spinal cord injuries
4. Antibiotic resistant bacteria frequently transmitted between intensive care patients
5. Antibiotic use on swine farms increases efficiency, profits
6. Antibiotic slows atherosclerosis in people with Chlamydia pneumonia antibodies
7. Antibiotics not always beneficial for childhood ear infections
8. Antibiotic could offer promise for treatment of cystic fibrosis
9. Antibiotics help heart patients
10. Antibiotic prescription patterns violate guidelines, increase costs
11. Antibiotic prescribing in local communities is linked to localised resistance

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2019)... ... 2019 , ... Kurt Hurley, a veteran marketing executive, joins ... care and occupational medicine, as the healthcare network’s new Chief Marketing Officer. Hurley ... industry developing and implementing integrated marketing communication plans to ensure top line growth ...
(Date:6/24/2019)... Pa. (PRWEB) , ... June 24, 2019 , ... ... for adolescents and adults, today announced the restructuring of the Strategic Advisory Board ... struggling to meet the demand for behavioral health care. , We ...
(Date:6/20/2019)... Okla. (PRWEB) , ... June 20, 2019 , ... ... pleased to announce their partnership with Physical Therapy Solutions in Lawton, which has ... C, the clinic is the group’s 28th clinic in the state. , ...
(Date:6/19/2019)... ... June 19, 2019 , ... The Clean Cooking ... 2018 by the Alliance and its partners. Under the theme “Investment. Innovation. Impact,” ... the clean cooking sector, including an entrepreneur and manufacturer in Africa, a health ...
(Date:6/19/2019)... ... June 19, 2019 , ... Ovation® Fertility scientists have been invited to ... and Embryology (ESHRE) Annual Meeting in Vienna, June 23-26, 2019. , Ovation’s oral ... for both the Basic Science Award for Oral Presentation and the Fertility Society of ...
Breaking Medicine News(10 mins):
(Date:6/24/2019)... ... 2019 , ... Prof. Yitshak Kreiss, Director General of Israel’s Sheba Medical Center ... the Palestinian people as part of a first step in a potential Israeli-Palestinian peace ... invited by U.S. Secretary of the Treasury Mr. Steven Mnuchin to the Peace and ...
(Date:6/20/2019)... ... June 20, 2019 , ... World Trade Center (WTC) responders ... Center site had activated chronic inflammation in their prostates, which may have contributed ... Cancer Research in June. , Inflammation has long been considered an important ...
(Date:6/19/2019)... ... June 19, 2019 , ... Cardiovascular diseases remain the ... all global deaths (17.9 million per year), and are the most expensive condition ... care pathways, treatment and real-time visualization of cardiac anomalies and subsequent therapy more ...
Breaking Medicine Technology:
Cached News: