HOME >> MEDICINE >> NEWS
Antibiotic rifampicin shows promise for fighting Parkinson's disease in lab tests

SANTA CRUZ, CA--Researchers at the University of California, Santa Cruz, have shown that rifampicin, an antibiotic used to treat leprosy and tuberculosis, can prevent the formation of protein fibrils associated with the death of brain cells in people with Parkinson's disease. The drug also dissolved existing fibrils in laboratory tests.

The researchers studied the effects of rifampicin in test tube experiments and are currently doing studies with cell cultures and mice to see if the same effects occur in living cells. Although these are just the first steps along the path toward clinical studies in humans, the findings suggest that rifampicin and related compounds might be effective in preventing fibril formation and associated neurological damage in patients with Parkinson's disease, said Anthony Fink, professor of chemistry and biochemistry at UCSC.

"Clearly, more work is needed to determine if this would work therapeutically, but if it does it would probably be most useful as a prophylactic therapy used in the early stages of the disease before there is general neurological damage," Fink said.

The research was carried out by a team of scientists in Fink's lab, including postdoctoral researchers Jie Li, Min Zhu, and Sudha Rajamani and research associate Vladimir Uversky. Li is first author of a paper describing their results in the November issue of the journal Chemistry and Biology, which is mailed and published online on November 29.

Aggregation of the protein known as alpha-synuclein into insoluble fibrils is thought to be a critical step in the development of Parkinson's disease, a progressive movement disorder resulting from the death of nerve cells in the brain that produce the neurotransmitter dopamine. Deposits called Lewy bodies, composed mostly of alpha-synuclein fibrils, appear in affected nerve cells, but the connection between the fibrils and cell death remains controversial, Fink said.

"There are t
'"/>

Contact: Tim Stephens
stephens@ucsc.edu
831-459-4352
University of California - Santa Cruz
29-Nov-2004


Page: 1 2 3

Related medicine news :

1. Antibiotics protect nerves in mice by turning on genes
2. Antibiotics within 4 hours of arrival at hospital better for pneumonia patients
3. Antibiotic provides promise in treatment of spinal cord injuries
4. Antibiotic resistant bacteria frequently transmitted between intensive care patients
5. Antibiotic use on swine farms increases efficiency, profits
6. Antibiotic slows atherosclerosis in people with Chlamydia pneumonia antibodies
7. Antibiotics not always beneficial for childhood ear infections
8. Antibiotic could offer promise for treatment of cystic fibrosis
9. Antibiotics help heart patients
10. Antibiotic prescription patterns violate guidelines, increase costs
11. Antibiotic prescribing in local communities is linked to localised resistance

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/7/2019)... ... November 07, 2019 , ... ALZYN, LLC today announced that The ... in 2019.’ , “The Silicon Review 50 Best Companies to Watch 2019 program ... world than others, and winning a spot on this list indicates the company has ...
(Date:11/6/2019)... ... 06, 2019 , ... Nellson, LLC (Nellson), a leading North ... recently achieved FSSC 22000 Certification of GFSA standard scheme at their Salt Lake ... that we have achieved FSSC 22000 compliance at our Salt Lake City facility,” ...
(Date:11/6/2019)... ... November 06, 2019 , ... Conducting Advanced Root ... Improve Inspections, An FDAnews Workshop, Nov. 13-14, 2019 • Philadelphia, PA, https://www.fdanews.com/capapc ... week. , Dear FDA-Regulated Executive, , CAPA failures show up in about half ...
(Date:11/5/2019)... HANOVER, N.J. (PRWEB) , ... November 05, 2019 , ... ... received the Humanitarian of the Year Award from Community Access Unlimited. The award was ... Marriott on October 24, 2019. , Katz was one of three members ...
(Date:11/4/2019)... Conn. (PRWEB) , ... November 04, 2019 , ... ... sound scientific validation in the Lyme treatment equation, Global Lyme Alliance (GLA) announced ... a series of clinical studies to determine the effectiveness of non-validated, physician-developed Lyme ...
Breaking Medicine News(10 mins):
(Date:11/9/2019)... Calif. (PRWEB) , ... November 08, 2019 , ... ... facial plastic surgeon with extraordinary surgical skills. As a trained sculptor and painter, ... to create harmonious, natural-looking results for each patient. Dr. Sadati has made appearances ...
(Date:11/9/2019)... ... , ... “Strong, silent” types with their “stiff upper lips” ... characters, like James Bond and Sherlock Holmes, and, let’s face it, pretty much ... in the most perilous and dire of situations? It's certainly more attractive than ...
(Date:11/6/2019)... PALM COAST, Fla. (PRWEB) , ... November 06, ... ... practitioner-channel dietary supplement company, is using its science-based nutrition philosophy to raise awareness ... 2 diabetes, which research suggests can also help reverse its progress. This is ...
Breaking Medicine Technology:
Cached News: