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Antibiotic slows atherosclerosis in people with Chlamydia pneumonia antibodies

DALLAS, Oct. 15 Long-term antibiotic treatment may slow the progress of early atherosclerosis in stroke patients who have antibodies to a pneumonia-causing bacteria in their bloodstream, scientists report in today's rapid access issue of Circulation: Journal of the American Heart Association.

"Our data imply for the first time to our knowledge that antibiotic treatment in patients over age 55 with Chlamydia pneumoniae (Cp) antibodies and prevalent cerebrovascular disease is associated with a reduced progression of early stages of carotid atherosclerosis," says study author Dirk Sander, M.D., a researcher with the neurology department at Technical University of Munich.

Chlamydia pneumoniae the bacteria that causes pneumonia has been associated with atherosclerosis. Studies have also associated the Cp antibody with heart attack and stroke. Other research has corroborated the association of Cp with atherosclerosis based on the organism's presence in atherosclerotic lesions and its absence in healthy artery tissue.

Other researchers have also described the benefits of antibiotics on vessel disease.

Sander's team evaluated the effect of the antibiotic roxithromycin on progressive thickening of the carotid (neck) artery in 272 stroke patients (average age 64) for two years. Of the 125 that tested positive for the Cp antibody, 62 received a twice-daily, 150-milligrams dose of roxithromycin, while 63 got twice-daily placebo for 30 days. Of the 147 Cp-negative patients, 74 were assigned to the drug and 73 to placebo.

Researchers measured intima to media thickness (IMT) of the common carotid artery with ultrasound. Increased IMT indicates atherosclerosis. Each patient had undergone both IMT and blood tests for Cp antibodies at least three years before the start of the study's antibiotic regimen. Patients infected with Cp in the past have antibodies that react when their blood is exposed to the microorganism in the laboratory.

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Contact: Carole Bullock
carole.bullock@heart.org
214-706-1279
American Heart Association
14-Oct-2002


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