esh, a pioneer in the field of
integrins, discovered these integrins and produced the antibody, the humanized
version known as Vitaxin, which is now undergoing clinical trials in people with
"The antibody appears to be well-tolerated in human patients," Lessey says.
In the UNC study, led by Lessey and members of the medical staff, Cheresh also
collaborated. Among animals treated with the antibody solution, were fewer, less
extensive and less dense post-surgical adhesions, compared to animals treated
with a control antibody. Moreover, there was no statistical difference between
adhesions in LM609-treated animals and animals that received a sham operation
(surgically opened and then closed).
"We propose to use LM609 or its humanized counterpart, in collaboration with Dr.
Cheresh, in a randomized, prospective trial of adhesion prevention in women
undergoing laparoscopy for endometriosis and/or pelvic adhesive disease, Lessey
says. "If this antibody can be shown to be efficacious in preventing adhesions
in women, a larger multi-center approach will be organized."
The researcher adds: "We hope it will be possible to prevent lesions before they
form. The implications of these neutralizing antibodies for surgery appear
Page: 1 2 Related medicine news :1
Contact: Lynn Wooten
University of North Carolina School of Medicine
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