HOME >> MEDICINE >> NEWS
Antibody treatment partially reverses nerve damage in Alzheimer disease

Researchers from Washington University School of Medicine have shown that an antibody treatment administered to the brain surface in mice with Alzheimer disease is capable of rapidly reversing disease-related structural nerve damage. The study will appear online on January 20 in advance of print publication in the February 1 issue of the Journal of Clinical Investigation.

One of the many hallmarks of Alzheimer disease is the presence of deposits or "plaques" made up of amyloid-beta peptide (Abeta) in areas of the brain responsible for memory and cognition. While several approaches to decreasing Abeta production or increasing its clearance from the brain are being studied as potential treatments for Alzheimer disease, it is not known whether, upon clearance of Abeta, if significant structural damage to nerves is reversed, remains, or continues.

Using a mouse model of Alzheimer disease in which a subset of neurons and Abeta in the mouse brain express colored fluorescent proteins that can be visualized in the living animal under a microscope, David Holtzman and colleagues administered an anti- Abeta antibody treatment and monitored the structural changes to nerves within the mouse brains. They observed that following treatment of the brain surface, there was a significant decrease in the amount of structural nerve damage after only 3 days. The study suggests that Abeta deposition leads to ongoing nerve damage and that upon reducing buildup of Abeta in the brain, this structural damage is rapidly reversible.

The imaging technique used will also be a valuable tool for the study of the progression of Abeta deposition in the brain during experimental models of Alzheimer disease and to also assess the effectiveness of treatments including the anti-Abeta antibody treatment described here.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
20-Jan-2005


Page: 1

Related medicine news :

1. Antibody may be risk factor for stroke in young women
2. Antibody solution may prevent adhesions after surgery
3. Breakthrough New Therapy Uses Antibody-Targeted Chemotherapy To Fight Leukemia
4. Promising New Drug Uses Antibody Targeted Chemotherapy To Fight Leukemia
5. Hormonal treatment improves survival in high-risk prostate cancer patients
6. Chronic pain treatments more effective when taken together, new study shows
7. Brain activity prior to treatment flags vulnerability to antidepressant side effects
8. Cultural and social factors influence prostate cancer treatment
9. Research offers hope of new treatments for liver damage
10. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
11. Stanford patient is first to test new treatment for peripheral arterial disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/7/2020)... ... 2020 , ... Twenty-six people, all but one who live with Young Onset ... YOPD attend the 6th World Parkinson Congress. The participants, representing 11 countries , ... all 52 weeks in 2020. The group aims to raise at least $50,000 for ...
(Date:1/7/2020)... , ... January 06, 2020 , ... After 32 years ... its first product: The LumaCare Duo ™. , The first public demonstrations of ... Convention Center in Las Vegas, Nevada during CES 2020, the largest consumer electronics trade ...
(Date:1/7/2020)... ANGELES (PRWEB) , ... January 06, 2020 , ... A ... a correlation between weight loss surgery and fewer complications including high blood pressure and ... had bariatric surgery between their first and their second pregnancies were less likely to ...
(Date:1/7/2020)... ... ... R3 Stem Cell is now offering access to all regenerative training courses ... and includes all the stem cell and exosome courses. , For several years, R3 ... the online regenerative training courses, R3 assembled all of the presentations and procedures into ...
(Date:1/5/2020)... PLAINS, N.J. (PRWEB) , ... January 04, 2020 , ... ... His practice, Shore Children’s Dental Care, specializes in treatment for infants, children, teens and ... is announcing a new center for infant nursing and oral health. , Dr. Sherman ...
Breaking Medicine News(10 mins):
(Date:1/8/2020)... ... January 08, 2020 , ... ... Medicare for medication-assisted treatment services at their Opioid Treatment Programs (OTPs) across ... medications, as well as counseling, began on January 1st. All BayMark branded ...
(Date:1/7/2020)... , ... January 06, 2020 , ... ... living with memory impairment, has announced the Best Memory Care Facilities in Fargo, ... to experts, facility features and amenities. , According to the Alzheimer’s ...
(Date:1/3/2020)... ... January 03, 2020 , ... ... helps radiologists to identify potential breast cancers earlier and faster, say a new ... radiologists already using the Transpara system in 15 countries, including Hungary, Turkey, the ...
Breaking Medicine Technology:
Cached News: