HOME >> MEDICINE >> NEWS
Antioxidant-Enhancing Drug Partly Rescues Noise-Induced Hearing Loss

BUFFALO, N.Y. -- Noise-induced hearing loss may be caused partly by free-radical oxidative damage to sensory cells in the inner ear, and a drug called R-PIA can lessen the extent of damage by enhancing antioxidant activity, researchers at the University at Buffalo's Center for Hearing and Deafness have found.

Results of their most recent study, which describes the action of R-PIA in an animal model, will be presented on Friday, Sept. 12, at the Inner Ear Biology Meeting in Bari, Italy.

Donald Henderson, Ph.D., UB professor of communicative disorders and sciences, said the action of R-PIA likely would be similar in the human ear.

"In the future, we may be able to rescue the hearing loss of persons inadvertently exposed to large amounts of noise, such as those near an explosion, for example, through the use of this drug."

Noise-induced hearing loss, a major health problem in industrialized societies, is a primary research focus of UB's Center for Hearing and Deafness, which Henderson co-directs with fellow scientist Richard J. Salvi, Ph.D.

The new study, conducted by Henderson and colleagues Sandra McFadden, Ph.D., and Bo-Hua Hu, Ph.D., along with Richard Kopke, Ph.D., of the U.S. Army, documents the action of R-PIA on noise-induced hearing loss in chinchillas, a mammal with an auditory range similar to that of humans.

In earlier work, the researchers showed that the stress of loud noises causes an increase in free radicals in the inner ear, which can damage or kill sensory cells. To defend themselves, sensory cells express a rush of glutathione, an antioxidant that absorbs free radicals. R-PIA was found to increase the activity of glutathione, thus providing enhanced protection from free-radical damage.

To test the effect of the drug on hearing loss, researchers applied R-PIA topically to the round window (inner-ear membrane) of one group of animals and applied a saline
'"/>

Contact: Lois Baker
baker@newsb.buffalo.edu
716-645-2626
University at Buffalo
12-Sep-1997


Page: 1 2

Related medicine news :

1. New Research Points The Way To Restoring Noise-Induced Hearing Loss In Mammals, Including Humans
2. Hearing aid signal not clear? Then switch frequency to FM, finds UCI study
3. Hearing problems may be programmed at birth
4. Hearing aid research gets federal boost
5. Hearing infants show preference for sign language over pantomime
6. Can We Prevent Hearing Loss In Elderly Women?
7. Study Of Women And Hearing Reveals Need For Routine Hearing Tests
8. Magnetic Hearing Aid Could Open New "Window" For Hearing Impaired
9. Drug Prevents Hearing Loss Caused By Brain Tumor Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based pharmaceutical distributor ... first responders across the United States. Since the start of the global COVID-19 ... medical centers , hospitals , firefighters , and public ...
(Date:8/31/2020)... ... August 31, 2020 , ... Smile Brands Inc., one ... the United States, today announced the grand opening of another affiliated Bright ... will enjoy convenient hours, a comfortable office, and full-service care at the new ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. Chang has ... with autism and other developmental disabilities, as well as supporting staff in caring ... with autism, school consultation, and staff development. She joined the company in 2015 ...
(Date:8/28/2020)... ... August 28, 2020 , ... WHAT , ... treat patients with respiratory conditions, including COVID-19, while reducing the need for scarce ... it captures exhaled gas and scrubs it free of carbon dioxide in a ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ziegler, a ... on its investment in Synchronous Health, a tech-enabled behavioral health and well-being solutions ... of human empathy with artificial intelligence (AI) to increase access and quality of ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... Continuing on ... a broad-spectrum sanitization, disinfection and deodorization provider - is proud to announce it ... disinfecting services for businesses and residents throughout the area. , Germinator provides a ...
(Date:8/28/2020)... LOS ANGELES (PRWEB) , ... August 28, 2020 ... ... of integrative medicine and aesthetic beauty, bringing a unique perspective and approach. Armed ... Toronto, Dr. Rahi ventured out to share her knowledge of the human body ...
(Date:8/27/2020)... ... August 27, 2020 , ... Bleep LLC, maker of the ... apnea patient, is the company’s new spokesperson. , “In my line of work, a ... I found the Bleep DreamPort it was a Bleeping no brainer for me,” said ...
Breaking Medicine Technology:
Cached News: