Artificial organs


In a bid to beat the problem, Borenstein teamed up with transplant surgeon Vacanti, who in 1997 famously grew a human ear from cartilage cells on the back of a mouse. The idea the pair hatched involves copying the blood vessel network of a real liver and using 3D computer modelling and machining to mimic its construction.

First, they injected a liquid plastic into the blood vessels of a liver. Once the plastic had solidified, they dissolved the liver tissue, leaving a solid cast of the organ's blood vessels. From this model they were able to take measurements of vessel diameters, branching angles and the distances between vessels. They fed the numbers into software that built a 3D fractal-like computer model of a liver's blood supply. When they simulated blood flowing through the "liver", it had the same blood flow properties as the living system, says Borenstein.

The 3D blood vessel model is then "sliced up" inside the computer, dividing the model into a series of horizontal layers, each of which is used to make a silicon mould. PLGA is then poured into each mould to make the many slices that when sandwiched together, under pressure and heat, create a scaffold for the artificial liver. It's shot through with channels as small as the finest capillaries and as large as the organ's main veins and arteries.

The scaffold then has to be seeded with the cells that make up the solid part of the liver. As well as hepatocytes, which perform key liver functions such as breaking down toxins and metabolising proteins and carbohydrates, there are at least six other types of cells. Borenstein says there are two possible ways of seeding this complex network of different cell types. You could seed each layer separately with different cell types, or inject them from the outside. But the pair won't yet say how this is done.

To get the blood supply working, a solution of endothelial cells, the cells that normally line blood vessels, is pumped into t

Contact: Claire Bowles
New Scientist

Page: 1 2 3

Related medicine news :

1. Artificial liver trials show progress, as transplant candidates wait
2. Artificial liver moves toward commercialization
3. New Type Of Artificial Surfactant Shows Promise In Treating Lung Disease
4. Trial Begins For First Artificial Liver Device Using Human Cells
5. Infectious agent linked to mad cow disease found in organs other than the brain
6. Blacks and poor more likely to donate than receive many types of transplant organs
7. Study finds HER2-positive breast cancer invades organs due to fatal chemical attraction
8. Targeting cell fusion as possible way to repair organs, deliver cancer vaccines
9. Improved procurement could more than double availability of life-saving transplant organs
10. Imaging study reveals effect of smoking on peripheral organs
11. PET scans show cigarette smoke affects peripheral organs

Post Your Comments:

(Date:10/13/2015)... ... October 13, 2015 , ... ActivePDF, a leading provider of ... to batch conversions of CAD drawings, plans, and diagrams to PDF that ... eliminates the complexity requirement of specialized applications to view CAD designs. Converting to ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... world’s first commercially-available next-generation sequencing laboratory test for bacterial vaginosis- a significant ... Obstetrics in Vancouver, BC, Canada. , In a presentation entitled: "The ...
(Date:10/12/2015)... , ... October 13, 2015 , ... ... its biannual Heroes in Recovery Awards at Foundations Recovery Network’s Moments of Change ... presented the one-of-a-kind awards to Noah Levine and Dean Dauphinais who exemplify the ...
(Date:10/12/2015)... ... ... article published October 6th by the Herald Tribune, a recent study that compared ... 1988 has shown that it really is more difficult to lose weight these days. Specifically, ... 1971 would be on average 10 pounds heavier than their past counterpart. In terms of ...
(Date:10/12/2015)... ... ... Amerec , a leader in the steam and sauna industry, and ... displaying custom sauna and steam room solutions at the ISPA Conference & Expo in ... SpaEquip is recognized for their ability to assist in the design and implementation of ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... 12, 2015  CME Group,s Center for Innovation ... of Theranos, is the 11 th recipient of the ... revolutionary blood diagnostics company, Theranos , to change health ... a new era of preventive care. CME Group will present ... Conference in Naples, Florida , on ...
(Date:10/12/2015)... , Oct. 12, 2015 ... -based medical technology company that designs ... announced today it has entered into a ... a company dedicated to producing devices, software ... health. SensiLase PAD-IQ®, developed and produced by ...
(Date:10/12/2015)... 2015  To help address the growing opioid epidemic ... Surgeons (AAOS) Board of Directors is calling for ... patient education; the tracking of opioid prescription use; research ... effective opioid abuse treatment programs. David Ring ... Safety Committee. "The new , AAOS Information Statement on ...
Breaking Medicine Technology:
Cached News: