HOME >> MEDICINE >> NEWS
Artificial organs

t.

In a bid to beat the problem, Borenstein teamed up with transplant surgeon Vacanti, who in 1997 famously grew a human ear from cartilage cells on the back of a mouse. The idea the pair hatched involves copying the blood vessel network of a real liver and using 3D computer modelling and machining to mimic its construction.

First, they injected a liquid plastic into the blood vessels of a liver. Once the plastic had solidified, they dissolved the liver tissue, leaving a solid cast of the organ's blood vessels. From this model they were able to take measurements of vessel diameters, branching angles and the distances between vessels. They fed the numbers into software that built a 3D fractal-like computer model of a liver's blood supply. When they simulated blood flowing through the "liver", it had the same blood flow properties as the living system, says Borenstein.

The 3D blood vessel model is then "sliced up" inside the computer, dividing the model into a series of horizontal layers, each of which is used to make a silicon mould. PLGA is then poured into each mould to make the many slices that when sandwiched together, under pressure and heat, create a scaffold for the artificial liver. It's shot through with channels as small as the finest capillaries and as large as the organ's main veins and arteries.

The scaffold then has to be seeded with the cells that make up the solid part of the liver. As well as hepatocytes, which perform key liver functions such as breaking down toxins and metabolising proteins and carbohydrates, there are at least six other types of cells. Borenstein says there are two possible ways of seeding this complex network of different cell types. You could seed each layer separately with different cell types, or inject them from the outside. But the pair won't yet say how this is done.

To get the blood supply working, a solution of endothelial cells, the cells that normally line blood vessels, is pumped into t
'"/>

Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-207-331-2751
New Scientist
24-Apr-2002


Page: 1 2 3

Related medicine news :

1. Artificial liver trials show progress, as transplant candidates wait
2. Artificial liver moves toward commercialization
3. New Type Of Artificial Surfactant Shows Promise In Treating Lung Disease
4. Trial Begins For First Artificial Liver Device Using Human Cells
5. Infectious agent linked to mad cow disease found in organs other than the brain
6. Blacks and poor more likely to donate than receive many types of transplant organs
7. Study finds HER2-positive breast cancer invades organs due to fatal chemical attraction
8. Targeting cell fusion as possible way to repair organs, deliver cancer vaccines
9. Improved procurement could more than double availability of life-saving transplant organs
10. Imaging study reveals effect of smoking on peripheral organs
11. PET scans show cigarette smoke affects peripheral organs

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Artificial organs

(Date:10/22/2014)... Va. (PRWEB) October 22, 2014 ... Innovation , which is dedicated to distribute health ... of healthcare delivery worldwide announced the development of ... which patients expect when receiving healthcare. These are ... for patient-centered care: “providing care that is respectful ...
(Date:10/22/2014)... Best Cheap Hosting USA is among the most ... recently announced that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is the ... the world. , “iPower is one of the most ... various kinds of useful products for new and old ... customer service and a number of features which will ...
(Date:10/22/2014)... CA (PRWEB) October 22, 2014 Lintelus, ... Cormier, Sr. Vice President of Sales, will be speaking ... upcoming Meetings Technology Expo on October 28, at the ... be hosting a booth as well as a Tech ... Lintelus Meeting can create a more engaging event experience. ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter , ... in vitro fertilization (IVF) are only about half as likely ... reproduction technique, new research indicates, and the racial disparity persists ... about 31 percent of white patients became pregnant after IVF, ... more than 4,000 IVF cycles over two years to tease ...
(Date:10/22/2014)... News) -- Measures taken by Firestone officials at the ... have limited the spread of the disease there and ... Natural Rubber Co. provides health services to about 80,000 ... populated communities. Between Aug. 1 and Sept. 23, ... those 80,000 people. That incidence rate of 0.09 percent ...
Breaking Medicine News(10 mins):Health News:The Sullivan Institute for Healthcare Innovation Announces Release of Guiding Principles for Patient Experience-Centered Care 2Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2
(Date:10/22/2014)... Oct. 22, 2014 Provectus Biopharmaceuticals, Inc. (NYSEMKT: ... its novel investigational drug for cancer, is designed for ... side effects. Its oncology focus is on melanoma, breast ... phase 2 trials of PV-10 as a therapy for ... for atopic dermatitis and psoriasis. This ...
(Date:10/22/2014)... NORWALK, Conn. , Oct. 22, 2014  Recently ... (GERD) have bolstered the already substantial database of evidence. ... and adoption of Stretta therapy for sufferers ... of clinical evidence supporting Stretta therapy as ... coverage policies that make Stretta therapy available to nearly ...
(Date:10/22/2014)... SHANGHAI , Oct. 22, 2014   ... and WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... comprehensive genomic profiling to biopharmaceutical companies conducting clinical trials ... Under the terms of the collaboration, Foundation Medicine will ... of Foundation Medicine,s FoundationOne® assay at the WuXi Genome ...
Breaking Medicine Technology:Provectus Biopharmaceuticals Looks at the Asian Markets: Analyst Coverage by Small Cap Traders 2Recent Clinical Study Data Confirms Efficacy of Stretta Therapy - Spurs Additional Insurance Coverage and Financing Round 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 3Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 4Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 5
Cached News: