HOME >> MEDICINE >> NEWS
Aspirin does not reduce effectiveness of ACE inhibitors

A systematic review in this week's issue of THE LANCET provides clarification for the debate about the use of angiotensin-converting-enzyme (ACE) inhibitors in combination with aspirin for the treatment of cardiovascular disease-combination therapy does not reduce the effect of ACE inhibition.

Previous research has suggested that ACE inhibitors may be less effective in patients who also receive aspirin for the treatment of cardiovascular disease. Salim Yusuf from McMaster University, Hamilton, Canada, and colleagues did a systematic overview of data from around 22,000 patients from six long-term randomised trials of ACE inhibitors to assess whether aspirin altered the effects of ACE inhibitor therapy on major clinical outcomes (a combination of death, heart attack, stroke, hospital admission for congestive heart failure, or coronary artery revascularisation).

With the exception of one randomised trial, the efficacy of ACE inhibitors was not found to be altered (either positively or negatively) among patients who were also receiving aspirin. Overall, ACE inhibitor therapy significantly reduced the risk of the major clinical outcomes by 22%, with clear reductions in the risk both among those receiving or not receiving aspirin at the start of the randomised trials.

Salim Yusuf comments: "Even though results from the present analyses cannot rule out the possibility of some sort of interaction, they show unequivocally that even if aspirin is given, the addition of ACE inhibitor therapy produced substantial additional benefit in all major vascular outcomes. Therefore, in the absence of clear contraindications, concomitant use of aspirin and ACE inhibitors should be considered in all patients at high risk of major vascular events."


'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-207-424-4949
Lancet
3-Oct-2002


Page: 1

Related medicine news :

1. Aspirins potential ability to prevent colon polyps may not apply equally to all
2. Aspirin underused to reduce heart disease risk in diabetic women and young adults
3. Long Island Breast Cancer Study data: Aspirin helps protect some women against breast cancer
4. Aspirin use associated with reduced risk of breast cancer
5. Aspirin use may be associated with increased risk of pancreatic cancer
6. Aspirin is most cost effective way to prevent heart disease
7. Aspirin withdrawal may pose risk to coronary patients
8. Aspirin may help prevent pancreatic cancer
9. Aspirins target, the COX-2 enzyme, linked to cancer of the uterus
10. Aspirin within two days of ischemic stroke reduces deaths
11. Aspirin steps up as anti-inflammatory for arteries

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Aspirin does not reduce effectiveness ACE inhibitors

(Date:3/5/2015)... HomeCEUConnection.com is proud to support Nutrition ... their nutrition CEUs. To raise awareness on ... is offering 10% off selected nutrition CEU ... . , High Quality Continuing Education for ... continuing education courses for Physical Therapists, Physical ...
(Date:3/5/2015)... Rosa, CA (PRWEB) March 05, 2015 SuperCloset ... a SuperPro! The series aims to teach viewers everything ... garden with hydroponics. Grow Like a SuperPro takes you from ... between. From how to clone, to how to prune Grow ... growing. They are offering the whole series for download for ...
(Date:3/5/2015)... At the 7th Annual Mississippi Addiction ... treatment met today in Jackson, Mississippi to listen to ... the numerous respected speakers will be William S. ... that pain medications have had in today’s opiate overdose ... "It is hard to believe that much of the ...
(Date:3/5/2015)... 2015 Califia Farms , the ... natural products coffee drinks category[1], today unveils its new ... in Anaheim, Calif. Concentrated Cold Brew (CCB) is ... which democratizes the next wave of the coffee-taste evolution ... to become their own baristas. , Califia Farms ...
(Date:3/5/2015)... Supply & Demand Chain Executive Magazine ... to Know” in the supply chain industry, and we ... leadership team were included on this year’s list! Russ ... award due to their hard work, their commitment to ... and resolving client needs and challenges. , ...
Breaking Medicine News(10 mins):Health News:HomeCEUConnection.com Offers Nutrition CEUs this March to Celebrate Nutrition Month 2Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 2Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 3Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 2Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 3Health News:Califia Farms Personalizes At-Home Coffee Experience with the Launch of Concentrated Cold Brew Coffee 4Health News:MEBC Leaders Awarded Supply Demand Chain Executive Pros to Know Title For 2015 2
(Date:3/5/2015)... March 5, 2015 Soligenix, Inc. (OTCQB: SNGX) ... committed to developing products that address unmet medical needs ... today that its President and Chief Executive Officer, ... presentation at the 27 th Annual ROTH Conference ... Tuesday, March 10, 2015 at 1:00 PM Pacific Daylight ...
(Date:3/5/2015)... , March 5, 2015 ... new generation of OASIS *    at ECR ... processing power will set a benchmark for patient-centric care. ... and prevent delays whilst optimizing workflow management and costs. ... comfort and safety for imaging in Neurology, Orthopaedics, Paediatrics, ...
(Date:3/5/2015)... Denmark , March 5, 2015 ... that applies its innovative TransCon technology to address ... present two posters at the ENDO 2015 conference ... The posters will be presented on Thursday, March ... is being held from 1:00pm-3:00pm PST, and are ...
Breaking Medicine Technology:Soligenix to Present at the 27th Annual ROTH Conference 2Soligenix to Present at the 27th Annual ROTH Conference 3Hitachi Medical Systems Europe Launches the New Generation of OASIS*- The World's Most Powerful Open High-Field 1.2T MRI - A New Level in Patient-Centric Care 2Hitachi Medical Systems Europe Launches the New Generation of OASIS*- The World's Most Powerful Open High-Field 1.2T MRI - A New Level in Patient-Centric Care 3Ascendis Pharma to Present at ENDO 2015 2
Cached News: