HOME >> MEDICINE >> NEWS
Avoiding wishful thinking over new drugs more trials should be double-blinded say cancer experts

Italian researchers have urged that doctors should, wherever possible, be blinded to which drug a patient is receiving in a trial when the endpoint involves subjective judgements by the investigators.

They believe it would lessen the risk of wishful thinking an unconscious tendency by doctors to expect new drugs to perform better than the older ones they are being tested against.

This perception of a drugs effectiveness was named wish bias', when it was first reported more than a decade ago. In a report published in the current issue of Annals of Oncology* the research team says it may help to explain why the response rate of tumours to a new drug decreased over time.

Dr Roldano Fossati and colleagues from the Mario Negri Institute in Milan combed through the results of 29 randomised trials that took place between 1975 and 1999. They analysed the response rate of 2,234 women with advanced breast cancer who had been in the arms of the trials using the anti-cancer drug, doxorubicin (Adriamycin). They extracted the global (i.e. complete plus partial) response rate from all the trials.

"We found that every five years there was a 11% relative decrease in the odds of a global response and most of this decrease was in the partial response rate, where evaluation involves more subjective judgement than is involved in determining complete response," said Dr Fossati.

Of the 29 studies they investigated, only one had used a double blind** approach, and in two studies patients records were just externally audited.

"In these situations a bias due to financial and academic conflicts of interest or more subtle forms of wish bias could easily arise and account for an impression that when a drug is new it does better," said Dr Fossati.

The team carried out the assessment of the 29 studies to test their hypothesis that doctors unconscious favourable attitudes to new treatments may result in a tendency to overestimate their
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-1536-772181
European Society for Medical Oncology
12-Mar-2002


Page: 1 2

Related medicine news :

1. Chronic back pain shrinks thinking parts of the brain, study finds
2. Integration of agriculture, medicine requires new ways of thinking
3. Fit seniors better able to react when quick thinking needed, study says
4. Brain imaging technology can reveal what a person is thinking about
5. Research challenges conventional thinking on ways to treat prostate cancer
6. UW research shows risk factors for relapse among health care professionals who abuse drugs
7. New studies show mixed results on epilepsy drugs and birth defects
8. Newly discovered pathway might help in design of cancer drugs
9. Study examines consequences of Thailands war on drugs
10. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
11. Three anti-platelet drugs used in combination are safe

Post Your Comments:
(Date:12/20/2014)... New York, NY (PRWEB) December 20, 2014 ... with the healthcare sector have benefited the Massage ... Given the discretionary characteristics of industry products, the anticipated ... the five-year period has provided consumers with the means ... adults that have received a massage in a given ...
(Date:12/20/2014)... (HealthDay News) -- The holidays can be anything but ... fresh trees, scented candles and other allergy triggers. ... that have been packed away in dank basements or ... asthma patients," Dr. Rachna Shah, an affiliate faculty member ... in Loyola news release. Shah, who is also ...
(Date:12/20/2014)... 20, 2014 As Risperdal lawsuits ... in U.S. courts, Bernstein Liebhard LLP notes the ... children treated with the medication may experience elevated ... development and lactation. The study, which appears in ... adolescents who began treatment with risperidone, an antipsychotic ...
(Date:12/20/2014)... Aliso Viejo, California (PRWEB) December 20, 2014 ... have announced the release of a new plugin for ... Pixel Film Studios. , “TranSlice Volume 5 allows users ... literally hand draw it.” Said Christina Austin, CEO of ... to add level of professionalism while maintaining an easy ...
(Date:12/20/2014)... Today, Balfleet.com, one of the most ... offering 50%-70% off on its Mother of the ... mother of the bride dresses from Balfleet.com feature gorgeous ... accessible and takes pride in providing high quality dresses ... offering great discounts on our mother of the bride ...
Breaking Medicine News(10 mins):Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Holiday Trimmings Can Trigger Allergies 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 4Health News:Pixel Film Studios released a new transition entitled TranSlice Volume 5 exclusively for Final Cut Pro X 2Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2
(Date:12/17/2014)... and SAN DIEGO , Dec. 17, ... PHG ; AEX: PHIA) and Volcano Corporation (NASDAQ: ... solutions for cardiovascular applications, today announced that they have entered ... will commence a tender offer to acquire all of the ... share, or a total equity purchase price of USD 1 ...
(Date:12/17/2014)... , Dec. 17, 2014 With ... (MRI), the MRI market is seeing new growth, ... breast MRI scans account for the majority of ... higher resolution of images, which are creating opportunities for ... (MRI) market is growing at a rate of ...
(Date:12/17/2014)... MARLBOROUGH, Mass. , Dec. 17, 2014 /PRNewswire/ ... a biotechnology company focused on discovering, developing and ... using RNA-targeted technologies, today announced completion of enrollment in ... results from the 3-month observations confirmed the 1-month ... year:  Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
Breaking Medicine Technology:Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5
Cached News: