HOME >> MEDICINE >> NEWS
Avoiding wishful thinking over new drugs more trials should be double-blinded say cancer experts

Italian researchers have urged that doctors should, wherever possible, be blinded to which drug a patient is receiving in a trial when the endpoint involves subjective judgements by the investigators.

They believe it would lessen the risk of wishful thinking an unconscious tendency by doctors to expect new drugs to perform better than the older ones they are being tested against.

This perception of a drugs effectiveness was named wish bias', when it was first reported more than a decade ago. In a report published in the current issue of Annals of Oncology* the research team says it may help to explain why the response rate of tumours to a new drug decreased over time.

Dr Roldano Fossati and colleagues from the Mario Negri Institute in Milan combed through the results of 29 randomised trials that took place between 1975 and 1999. They analysed the response rate of 2,234 women with advanced breast cancer who had been in the arms of the trials using the anti-cancer drug, doxorubicin (Adriamycin). They extracted the global (i.e. complete plus partial) response rate from all the trials.

"We found that every five years there was a 11% relative decrease in the odds of a global response and most of this decrease was in the partial response rate, where evaluation involves more subjective judgement than is involved in determining complete response," said Dr Fossati.

Of the 29 studies they investigated, only one had used a double blind** approach, and in two studies patients records were just externally audited.

"In these situations a bias due to financial and academic conflicts of interest or more subtle forms of wish bias could easily arise and account for an impression that when a drug is new it does better," said Dr Fossati.

The team carried out the assessment of the 29 studies to test their hypothesis that doctors unconscious favourable attitudes to new treatments may result in a tendency to overestimate their
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-1536-772181
European Society for Medical Oncology
12-Mar-2002


Page: 1 2

Related medicine news :

1. Chronic back pain shrinks thinking parts of the brain, study finds
2. Integration of agriculture, medicine requires new ways of thinking
3. Fit seniors better able to react when quick thinking needed, study says
4. Brain imaging technology can reveal what a person is thinking about
5. Research challenges conventional thinking on ways to treat prostate cancer
6. UW research shows risk factors for relapse among health care professionals who abuse drugs
7. New studies show mixed results on epilepsy drugs and birth defects
8. Newly discovered pathway might help in design of cancer drugs
9. Study examines consequences of Thailands war on drugs
10. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
11. Three anti-platelet drugs used in combination are safe

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... ambulance transport experience for the millions of people who require these medical transport ... taxi industry through the use of technology. Now, SmartEMS has put forth an ...
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... 2016 Research and Markets ... Electronics 2015-2025: Applications, Technologies, Forecasts" report to ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, Composite ... Structural electronics involves electronic and/or electrical components and ... dumb structures such as vehicle bodies or conformally ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
Breaking Medicine Technology:
Cached News: