HOME >> MEDICINE >> NEWS
Avoiding wishful thinking over new drugs more trials should be double-blinded say cancer experts

Italian researchers have urged that doctors should, wherever possible, be blinded to which drug a patient is receiving in a trial when the endpoint involves subjective judgements by the investigators.

They believe it would lessen the risk of wishful thinking an unconscious tendency by doctors to expect new drugs to perform better than the older ones they are being tested against.

This perception of a drugs effectiveness was named wish bias', when it was first reported more than a decade ago. In a report published in the current issue of Annals of Oncology* the research team says it may help to explain why the response rate of tumours to a new drug decreased over time.

Dr Roldano Fossati and colleagues from the Mario Negri Institute in Milan combed through the results of 29 randomised trials that took place between 1975 and 1999. They analysed the response rate of 2,234 women with advanced breast cancer who had been in the arms of the trials using the anti-cancer drug, doxorubicin (Adriamycin). They extracted the global (i.e. complete plus partial) response rate from all the trials.

"We found that every five years there was a 11% relative decrease in the odds of a global response and most of this decrease was in the partial response rate, where evaluation involves more subjective judgement than is involved in determining complete response," said Dr Fossati.

Of the 29 studies they investigated, only one had used a double blind** approach, and in two studies patients records were just externally audited.

"In these situations a bias due to financial and academic conflicts of interest or more subtle forms of wish bias could easily arise and account for an impression that when a drug is new it does better," said Dr Fossati.

The team carried out the assessment of the 29 studies to test their hypothesis that doctors unconscious favourable attitudes to new treatments may result in a tendency to overestimate their
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-1536-772181
European Society for Medical Oncology
12-Mar-2002


Page: 1 2

Related medicine news :

1. Chronic back pain shrinks thinking parts of the brain, study finds
2. Integration of agriculture, medicine requires new ways of thinking
3. Fit seniors better able to react when quick thinking needed, study says
4. Brain imaging technology can reveal what a person is thinking about
5. Research challenges conventional thinking on ways to treat prostate cancer
6. UW research shows risk factors for relapse among health care professionals who abuse drugs
7. New studies show mixed results on epilepsy drugs and birth defects
8. Newly discovered pathway might help in design of cancer drugs
9. Study examines consequences of Thailands war on drugs
10. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
11. Three anti-platelet drugs used in combination are safe

Post Your Comments:
(Date:5/28/2015)... Medelis, Inc., a specialty oncology CRO ... in the role of president. , “ Bill Taaffe ... industry,” said Larry Flanagan, Medelis’ CEO and co-founder. “He will ... next phase of growth.” , Taaffe joined ICON’s U.S. ... employees to over 4,500 employees, achieving 12 consecutive years of ...
(Date:5/28/2015)... 2015 Altima Technologies, Inc., the ... for documenting and diagramming data center assets and ... following product lines: , Manufacturer / Device ... Products N-Series TeraFrame Cabinet, Middle Atlantic Products RSH ... Systems ForeRunner, Marantz America MM Series, Extron Electronics ...
(Date:5/28/2015)... Nidra Herbal Sleep Supplement features a 100% Ayurveda herbal ... supplement, Nidra Herbal Sleep Supplement is more than just a ... with a real sense of wellbeing the next day. ... as the “Science or Knowledge of Life”, was first used ... holistic system of knowledge which combines contemplation, herbal supplements and ...
(Date:5/28/2015)... McLean, VA (PRWEB) May 28, 2015 ... solutions, announced today that it is releasing BlueEHS, the ... an Amazon Machine Image for the benefit of all ... developer of BlueEHS, a first of its kind, Freemium, ... customizable Electronic Health Records (EHR) with an integrated practice ...
(Date:5/28/2015)... The connected car is gaining more traction with automakers. ... some iteration of a connected offering in the vehicle. ... as the data collected can be used to calculate ... This is the primary reason that 800+ senior figures ... & Exhibition. , Andrew Pym, TU Automotive’s research ...
Breaking Medicine News(10 mins):Health News:Bill Taaffe, Former President and CEO of ICON Clinical Research-US, Joins Medelis, a Specialty Oncology CRO, in the Role of President 2Health News:NetZoom™ Visio® Stencil Library Updates for EMC, Cisco, and Chatsworth Products 2Health News:Ayurveda Herba Corp’s Revolutionary Herbal Sleep Supplement is Now Available from Amazon.com 2Health News:BlueEHS, the Electronic Health Solution, now available on Amazon AWS Market place 2Health News:BlueEHS, the Electronic Health Solution, now available on Amazon AWS Market place 3Health News:TU-Automotive: North America’s Leading Insurers Head to Chicago as Connected Car Motor Insurance Shifts up a Gear 2Health News:TU-Automotive: North America’s Leading Insurers Head to Chicago as Connected Car Motor Insurance Shifts up a Gear 3
(Date:5/28/2015)... -- National Community Pharmacists Association (NCPA) CEO B. ... in response to a new report released ... number of generic drug costs increased substantially in 2013: ... expressed by NCPA and underscores the need for action ... Moreover, a 2015 survey of 700 community pharmacists concluded ...
(Date:5/28/2015)... 28, 2015  The U.S. Department of Justice (DOJ) ... and Rehab Medical Inc. to resolve a lawsuit that ... of a whistleblower lawsuit by two former employees of ... the direction of one of Orbit,s top executives, ... could obtain payment from Medicare for electric wheelchairs.  The ...
(Date:5/28/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/gsqwpp/proteomics ... new report "Proteomics - Technologies, Markets and ... report describes and evaluates the proteomic technologies that ... molecular diagnostics and practice of medicine in the ... 21st century. Most commonly used technologies are 2D ...
Breaking Medicine Technology:NCPA: AARP Drug Pricing Report Reiterates Need for Fair Generic Drug Reimbursements 2Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 2Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 3Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 4Global Proteomics Market 2015-2024 - Technologies, Markets and Companies (Updated Edition) 2Global Proteomics Market 2015-2024 - Technologies, Markets and Companies (Updated Edition) 3
Cached News: