HOME >> MEDICINE >> NEWS
Bacterial DNA reduces inflammation in mice

DNA from inactivated "probiotic" bacteria triggers a specific anti-inflammation immune response in mice with experimental colitis, researchers supported by the NIH's National Institute of Allergy and Infectious Diseases (NIAID) have discovered. Led by Eyal Raz, M.D., of the University of California, San Diego (UCSD), the investigators provide a possible explanation for the observed benefits of consuming probiotics, supplements from bacteria and other microbes, regarded by some as helpful in maintaining or restoring intestinal health. Knowing how probiotics work could give scientists a way to identify and select which probiotic bacteria might be effective against such human ailments as inflammatory bowel disease (IBD).

Probiotics have shown promise for treating such IBDs as Crohn's disease and ulcerative colitis, both of which cause periodic intestinal inflammation. But scientists have had many theories of how these mixtures of "good" bacteria work, notes Marshall Plaut, M.D., of NIAID's Division of Allergy, Immunology and Transplantation. Plausible theories suggested that proliferation of the living bacteria either generated helpful metabolic products or crowded out "bad" intestinal bugs. Prior to this study, the general thinking about probiotics, which include bacteria like those found in yogurt, has been that they mediate their effects through some kind of non-specific action, adds Dr. Plaut.

Dr. Raz and his colleagues, whose work is published in the February 2004 issue of the journal Gastroenterology, irradiated a commercially available probiotic preparation, halting bacterial proliferation, but preserving its DNA. When given to mice, the irradiated probiotics performed as well as live bacteria in reducing inflammation. They also found that purified probiotic bacterial DNA alone similarly reduces inflammation in mice with experimentally induced colitis.

The researchers also showed that probiotic DNA acts in a specific way by activating
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
2-Feb-2004


Page: 1 2

Related medicine news :

1. Bacterial infection may cause or worsen asthma attacks in children
2. Bacterial protein kills tumors
3. Bacterial vaginosis seems to affect miscarriage in early pregnancy
4. Geodon effective in psychiatric emergencies; Sharply reduces time in restraints
5. Targeting mutant B-Raf protein reduces melanoma development
6. Rasagiline reduces disability for patients with advanced Parkinsons disease
7. Breast cancer treatment reduces risk of heart disease
8. Carrot component reduces cancer risk
9. Sex hormone metabolite reduces stress, anxiety in female rats
10. Sunlight reduces risk of lymph gland cancer
11. Male circumcision reduces risk of HIV transmission from women to men

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... ... In the Health Care IT campaign, Robert Herjavec discusses health IT security ... will be attacked, but when.” However, he and many others involved highlight a promising ... in auditing and monitoring have taken security in health care a very long way. ...
(Date:2/24/2017)... ... February 24, 2017 , ... Healthcare Associates of McKinney announced ... Ranch building at 8080 State Highway 121, Suite 210, McKinney, Texas 75070. It ... Highway 121. , As the practice has grown, the need for more space has ...
(Date:2/24/2017)... ... February 24, 2017 , ... With ProGlass Prism users now ... . Users have total control over position, rotation, distortion, edge softness, edge blur, chromatic ... Cut Pro X. , With ProGlass Prism users are given the tools and ...
(Date:2/24/2017)... ... February 24, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... this present generation. Yisrayl makes an astounding statement when he says that the ... that the Bible details the current times so plainly that anyone should be able ...
(Date:2/24/2017)... , ... February 24, 2017 , ... Indiana Fiber Network ... the company later this year. Dyer started as the Chairman of the Management ... the establishment of the corporation including the recruitment of investor/owners and development of the ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)...  The particle counters market is projected to ... 275.9 million in 2016, at a CAGR of ... http://www.reportlinker.com/p04718602-summary/view-report.html The growing pharmaceutical and ... growth in manufacturing industries in emerging nations are ... counters. On the other hand, technical limitations of ...
(Date:2/23/2017)... , Feb. 23, 2017 Visiomed, ... and services since 1997, is changing the landscape ... technology providing patients with pro-active, custom-made solutions. Recognizing ... for instant and affordable healthcare without walls, Visiomed ... high-level devices developed with healthcare professionals that is ...
(Date:2/23/2017)... Feb. 23, 2017  Cogentix Medical, Inc. (NASDAQ: CGNT), ... innovative proprietary products for the urology market, will release ... ended December 31, 2016 before the market open on ... will host a conference call and webcast to discuss ... 9, 2017 at 11:00 a.m. Eastern Time (10:00 a.m. ...
Breaking Medicine Technology:
Cached News: