HOME >> MEDICINE >> NEWS
Behavioral sensitization: A new perspective on alcoholism

  • Alcoholics may drink because they get a "bigger bang" each time they drink.
  • This phenomenon is known as "behavioral sensitization."
  • Behavioral sensitization is the opposite of tolerance; it is even known as "reverse tolerance."
  • A neurochemical called MK-801 may block alcohol's sensitizing effects.
One of the ways by which people are believed to develop alcoholism is called "behavioral sensitization" to the effects of alcohol. This is another way of saying that each time someone drinks, they may find the alcohol more rewarding. In a recent study published in the March issue of Alcoholism: Clinical & Experimental Research, researchers explained how they may have found a way to "block" the increasingly rewarding effects of alcohol.

"What we've tried to show in this study," said Rosana Camarini, the study's lead author who is conducting post-doctoral research in neurology at the University of California San Francisco, "is that it may be possible to block behavioral sensitization to alcohol by using NMDA receptor antagonists. The specific one we studied is called MK-801."

Alcohol affects virtually every organ system in the body and alters the activity of most major neurochemicals. Alcohol's effects on the glutamate system are of particular interest to researchers. Glutamate acts as one of the brain's endogenous (made within the body) excitatory systems. A subtype of glutamate receptors, the n-methyl-d-aspartate (NMDA) receptor, is highly sensitive to low doses of alcohol. Evidence indicates that alcohol may interact directly with the NMDA receptor complex. Indeed, NMDA receptors may be involved in sensitization to, tolerance of, and physical dependence on a variety of drugs, including opiates, nicotine, antidepressants and alcohol. NMDA receptor antagonists - in this case, MK-801 - appear to be able to "block" some of the pleasing effec
'"/>

Contact: Rosana Camarini, Ph.D.
rosanac@itsa.ucsf.edu
510-985-3924
Alcoholism: Clinical & Experimental Research
13-Mar-2000


Page: 1 2 3 4

Related medicine news :

1. 2005 Behavioral Sciences & Health Services Research Award
2. Behavioral symptoms may indicate increased smoking risk among adolescents
3. 2004 Behavioral Sciences/Health Services Award to Helen Gift
4. NHGRI launches Social and Behavioral Research Branch
5. Behavioral therapies plus pharmacotherapies can add up to success
6. Behavioral program boosts antibody that fights breast cancer
7. Parenting CD-ROM Helps Reduce Childrens Behavioral Problems
8. Landmark Study Shows Behavioral Interventions Reduce HIV-Related Sexual Risk Behavior
9. Most Comprehensive Study Of Its Kind Shows Common Asthma Medications Dont Cause Behavioral Problems In Children, According To The Journal Pediatrics
10. Rhesus monkeys reason about perspectives of others in obtaining food
11. CT with multiplanar reconstruction gives new perspective on complex ankle fractures

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/14/2018)... Ark. (PRWEB) , ... November 14, 2018 , ... ... Springs, Searcy, Cabot, Jacksonville, Austin, Ward and Romance, is celebrating its official grand opening ... 2018. Local families are encouraged to like and follow the Acti-Kare Facebook ...
(Date:11/14/2018)... ... November 14, 2018 , ... PAINWeekEnd on Saturday, December ... be an educational and exciting program providing busy clinicians and allied healthcare practitioners with ... According to the National Institute on Drug Abuse, Maryland is among the top five ...
(Date:11/14/2018)... Ill. (PRWEB) , ... November 14, 2018 , ... ... Period (OEP) is now underway began Nov. 1, 2018 and continues through Dec. ... prepared and gather necessary information, it does not have to be an overwhelming ...
(Date:11/13/2018)... ... November 14, 2018 , ... REMS: Requirements, Regulation, ... 28, 2018 — 1:30 p.m. – 3:00 p.m. ET, http://www.fdanews.com/remsrre ... a powerful enforcement tool. A constantly evolving enforcement tool. , In September the ...
(Date:11/13/2018)... , ... November 13, 2018 , ... ... device industries, announced today the opening of its newest laboratory located in Cary, ... aims to provide comprehensive services to top U.S. manufacturers and brings additional jobs ...
Breaking Medicine News(10 mins):
(Date:11/15/2018)... ... November 15, 2018 , ... ... Program (OTP) with locations in Salt Lake City and Ogden, Utah earlier ... a high-quality, trusted provider of evidence-based treatment for opioid addiction. The Metamorphosis ...
(Date:11/15/2018)... ... November 15, 2018 , ... In this month’s NEPC ... Gregory A. Smith and Cornell University professor Noliwe Rooks discuss ... , who also chairs the American Studies Program at Cornell, explore issues that have ...
(Date:11/15/2018)... (PRWEB) , ... November 15, 2018 , ... ... cloud computing arm of Alibaba Group, signed a Memorandum of Understanding (MoU) today ... areas of smart cities and smart healthcare. The two parties hope to translate ...
Breaking Medicine Technology:
Cached News: