HOME >> MEDICINE >> NEWS
Behavioral sensitization: A new perspective on alcoholism

  • Alcoholics may drink because they get a "bigger bang" each time they drink.
  • This phenomenon is known as "behavioral sensitization."
  • Behavioral sensitization is the opposite of tolerance; it is even known as "reverse tolerance."
  • A neurochemical called MK-801 may block alcohol's sensitizing effects.
One of the ways by which people are believed to develop alcoholism is called "behavioral sensitization" to the effects of alcohol. This is another way of saying that each time someone drinks, they may find the alcohol more rewarding. In a recent study published in the March issue of Alcoholism: Clinical & Experimental Research, researchers explained how they may have found a way to "block" the increasingly rewarding effects of alcohol.

"What we've tried to show in this study," said Rosana Camarini, the study's lead author who is conducting post-doctoral research in neurology at the University of California San Francisco, "is that it may be possible to block behavioral sensitization to alcohol by using NMDA receptor antagonists. The specific one we studied is called MK-801."

Alcohol affects virtually every organ system in the body and alters the activity of most major neurochemicals. Alcohol's effects on the glutamate system are of particular interest to researchers. Glutamate acts as one of the brain's endogenous (made within the body) excitatory systems. A subtype of glutamate receptors, the n-methyl-d-aspartate (NMDA) receptor, is highly sensitive to low doses of alcohol. Evidence indicates that alcohol may interact directly with the NMDA receptor complex. Indeed, NMDA receptors may be involved in sensitization to, tolerance of, and physical dependence on a variety of drugs, including opiates, nicotine, antidepressants and alcohol. NMDA receptor antagonists - in this case, MK-801 - appear to be able to "block" some of the pleasing effec
'"/>

Contact: Rosana Camarini, Ph.D.
rosanac@itsa.ucsf.edu
510-985-3924
Alcoholism: Clinical & Experimental Research
13-Mar-2000


Page: 1 2 3 4

Related medicine news :

1. 2005 Behavioral Sciences & Health Services Research Award
2. Behavioral symptoms may indicate increased smoking risk among adolescents
3. 2004 Behavioral Sciences/Health Services Award to Helen Gift
4. NHGRI launches Social and Behavioral Research Branch
5. Behavioral therapies plus pharmacotherapies can add up to success
6. Behavioral program boosts antibody that fights breast cancer
7. Parenting CD-ROM Helps Reduce Childrens Behavioral Problems
8. Landmark Study Shows Behavioral Interventions Reduce HIV-Related Sexual Risk Behavior
9. Most Comprehensive Study Of Its Kind Shows Common Asthma Medications Dont Cause Behavioral Problems In Children, According To The Journal Pediatrics
10. Rhesus monkeys reason about perspectives of others in obtaining food
11. CT with multiplanar reconstruction gives new perspective on complex ankle fractures

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... ... August 17, 2018 , ... An August 7 article ... premature births and low birth weight could be significantly reduced if women were more ... gingivitis (gum disease) which a very large number of pregnant women suffer from to ...
(Date:8/15/2018)... ... August 15, 2018 , ... Today David Hyde Apparel debuts the first, fully ... out of a desire for confidence and comfort year-round, the new shirt leverages a ... in the hottest, most humid of climates. , The brainchild of two recent University ...
(Date:8/14/2018)... MIAMI (PRWEB) , ... August 14, 2018 , ... ... fastest-growing gastroenterology groups, today announced new leadership roles for healthcare executives Simon Frisch ... Division Vice President, Florida, respectively. They assume their roles at a time of ...
(Date:8/11/2018)... ... 10, 2018 , ... Dr. Siavash Eftekhari, Oral and Maxillofacial Surgeon at ... international outpost trip to deliver dental care in impoverished communities. Along with a team ... volunteered his time to help deliver care to over 550 individuals in need. , ...
(Date:8/9/2018)... ... August 09, 2018 , ... Thousands of US ... according to cross-referenced data from The American Society of Plastic Surgeons (ASPS), The ... monitored by the FDA. As an MRI is recommended by FDA after the ...
Breaking Medicine News(10 mins):
(Date:8/7/2018)... ... August 07, 2018 , ... ... of Richard A. Stark to assume the role of Sanarus Technologies President, effective immediately. Mr. ... of strategic development, marketing and sales experience in medical device toward finding new and ...
(Date:8/3/2018)... ... August 03, 2018 , ... In order to improve safety for everyone ... be mindful of the significant risks of injury that many amusement park rides present ... the Ferris wheel or a thrilling ride on a roller coaster. Unfortunately, these fun ...
(Date:8/2/2018)... ... August 02, 2018 , ... Periodontist, Dr. Andres ... crown lengthening treatment at his Eden Prairie, MN practice. Aesthetic crown ... self-conscious. Using decades of experience, Dr. Sanchez is excited to welcome new patients ...
Breaking Medicine Technology:
Cached News: