HOME >> MEDICINE >> NEWS
Better control of liver enzymes saves lives of HIV patients, says University Of Pittsburgh

PITTSBURGH, July 8 Mild to moderate elevations in two liver enzymes increments that are commonly ignored by most physicians are related to an increased risk of death in people with HIV, according to a University of Pittsburgh researcher who presented the findings July 8 at the XIV International AIDS Conference in Barcelona.

The enzymes are alanine transamine (ALT) and aspartamine transamine (AST).

"Up to one third of HIV patients have mild to moderate elevations in ALT and AST, yet physicians largely disregard the readings unless they are two to four times above the normal range," said Amy Justice, M.D., associate professor of health services research at the University of Pittsburgh Graduate School of Public Health, associate professor of medicine at the University of Pittsburgh School of Medicine, and staff physician at the Pittsburgh Veterans Administration Medical Center. "Our study shows that even patients whose elevations are mild to moderate have a death rate that is nearly twice that of patients with mid-range normal levels. This association with increased mortality suggests that any elevation in ALT and AST should be addressed."

Elevations in these enzymes signal injury to liver cells and, in some cases, to other cells in the body. The condition can result from highly active anti-retroviral therapy (HAART), viral hepatitis or alcohol abuse, all of which are toxic to liver cells. Liver failure is the most common cause of death in people with AIDS.

While ALT and AST testing is routine in monitoring of HIV patients, elevations are not typically addressed unless they are more than twice what is considered normal. The standard remedy for extremely high ALT and AST levels is to stop or change antiretroviral medications and to counsel patients to stop drinking alcohol. Mild to moderate elevations (0.5 up to 2 times the normal level) currently are not treated.

The Pittsburgh-led study was an analysis of data on more than 5
'"/>

Contact: Kathryn Duda
412-624-2607
University of Pittsburgh Medical Center
8-Jul-2002


Page: 1 2

Related medicine news :

1. Innovation prize finalists announced in Science of Better
2. Disaster management: Better management of hospital resources and staff is the answer
3. Better research needed to assess psychological and social effects of cannabis
4. Better predictors are needed for posttraumatic stress disorder in children
5. Better brain imaging helps surgeons avoid damage to language functions
6. Better outcome for ICU patients after removal of bacteria from digestive tract
7. Better care and better communication urgently needed
8. Better access to health care is key to higher survival rates for African-Americans with colon cancer
9. Better understanding of prognosis linked to greater emphasis on easing suffering of children with advanced cancer
10. Better diagnosis of pain in children
11. Better psychiatric support needed for children who lose a parent

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... ... Steven Tonkinson, 36, of Coconut Grove, Florida, ran the Miami Marathon on January ... year, he ran all 26.2 miles with a green 25-pound ShelterBox strapped to his ... This Sunday, while many are watching the Superbowl, Steven Tonkinson will strap on the ...
(Date:2/5/2016)... NY & Salt Lake City, UT (PRWEB) , ... February 05, ... ... Founder of Activz Whole-Food Nutrition , announced that the much-anticipated feature with author ... the New Really Cool Humans Amateur TV Network. , Each week, on his weekly ...
(Date:2/5/2016)... ... February 05, 2016 , ... The ... Popeyes Louisiana Kitchen restaurants, launched the 14th annual “Appetite for a Cure” campaign ... with muscular dystrophy, ALS and related diseases that severely limit strength and mobility. ...
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University ... Allen have signed a joint enrollment and degree completion agreement. The agreement, ... and baccalaureate degrees at FHU|Dickson. , The agreement allows students to be ...
(Date:2/5/2016)... ... February 05, 2016 , ... US Sports Camps , official operators ... to direct high-performance kids yoga training. ChildLight Yoga Studio is centrally situated in the ... Boston. , ChildLight Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 4, 2016 For hospitals considering enrollment in ... participating in the program, the Health Resources and Services ... the , Mega-Guidance , could have significant impact on ... in September 2016. Essential Insights , ... , summarizes the Mega-Guidance,s key proposed changes, including a ...
(Date:2/4/2016)... , Feb. 4, 2016  The Senior Care ... Government Reform Committee Chairman Jason Chaffetz ... holding today,s hearing , "Developments in the ... increases and growing questions about abusive pharmacy benefit ... (R-UT) and Ranking Member Elijah Cummings (D-MD) ...
(Date:2/4/2016)... Feb. 4, 2016   Bernstein Liebhard LLP today ... the United States District Court for the District of ... "Class") consisting of all persons or entities who purchased common ... INSY ) from March 3, 2015 through January 25, ... of its officers with violations of the Securities Exchange Act ...
Breaking Medicine Technology:
Cached News: