HOME >> MEDICINE >> NEWS
Better control of liver enzymes saves lives of HIV patients, says University Of Pittsburgh

PITTSBURGH, July 8 Mild to moderate elevations in two liver enzymes increments that are commonly ignored by most physicians are related to an increased risk of death in people with HIV, according to a University of Pittsburgh researcher who presented the findings July 8 at the XIV International AIDS Conference in Barcelona.

The enzymes are alanine transamine (ALT) and aspartamine transamine (AST).

"Up to one third of HIV patients have mild to moderate elevations in ALT and AST, yet physicians largely disregard the readings unless they are two to four times above the normal range," said Amy Justice, M.D., associate professor of health services research at the University of Pittsburgh Graduate School of Public Health, associate professor of medicine at the University of Pittsburgh School of Medicine, and staff physician at the Pittsburgh Veterans Administration Medical Center. "Our study shows that even patients whose elevations are mild to moderate have a death rate that is nearly twice that of patients with mid-range normal levels. This association with increased mortality suggests that any elevation in ALT and AST should be addressed."

Elevations in these enzymes signal injury to liver cells and, in some cases, to other cells in the body. The condition can result from highly active anti-retroviral therapy (HAART), viral hepatitis or alcohol abuse, all of which are toxic to liver cells. Liver failure is the most common cause of death in people with AIDS.

While ALT and AST testing is routine in monitoring of HIV patients, elevations are not typically addressed unless they are more than twice what is considered normal. The standard remedy for extremely high ALT and AST levels is to stop or change antiretroviral medications and to counsel patients to stop drinking alcohol. Mild to moderate elevations (0.5 up to 2 times the normal level) currently are not treated.

The Pittsburgh-led study was an analysis of data on more than 5
'"/>

Contact: Kathryn Duda
412-624-2607
University of Pittsburgh Medical Center
8-Jul-2002


Page: 1 2

Related medicine news :

1. Innovation prize finalists announced in Science of Better
2. Disaster management: Better management of hospital resources and staff is the answer
3. Better research needed to assess psychological and social effects of cannabis
4. Better predictors are needed for posttraumatic stress disorder in children
5. Better brain imaging helps surgeons avoid damage to language functions
6. Better outcome for ICU patients after removal of bacteria from digestive tract
7. Better care and better communication urgently needed
8. Better access to health care is key to higher survival rates for African-Americans with colon cancer
9. Better understanding of prognosis linked to greater emphasis on easing suffering of children with advanced cancer
10. Better diagnosis of pain in children
11. Better psychiatric support needed for children who lose a parent

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... Livermore, California (PRWEB) , ... December 02, 2016 ... ... business professionals, proudly announces the launch of its 60-day free trial program for ... round trip shipping make the offer a truly hassle free experience. , FlexiSpot’s ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... With the ... through rehabilitation of an injury, patients must find the one that works for them. ... pain, he created a machine that worked and decided to share it with others. ...
(Date:12/2/2016)... ... 02, 2016 , ... Mediaplanet is proud to announce the ... the innovative treatments, therapeutic technologies, and revolutionized nutrition that are helping patients and ... 6 years in the last 3 decades,” says Dr. Valentine Fuster, a world-renowned ...
(Date:12/2/2016)... ... December 02, 2016 , ... Sourced from the Isbre Springs ... properties including its unmatched natural purity of just 6 ppm TDS (Total Dissolved Solids) ... Nothing Water has been available in several ShopRite and FoodTown stores in NJ and ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... announced today that it has raised $6.0 million in an initial round of ... Health’s conviction that patients and their caregivers can receive far better care through ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2, 2016 On Thursday, the NASDAQ ... Dow Jones Industrial Average edged 0.36% higher, to finish at ... Losses were broad based as six out of nine sectors ... reports on the following Services equities: Myriad Genetics Inc. (NASDAQ: ... ), INC Research Holdings Inc. (NASDAQ: INCR ), ...
(Date:12/2/2016)... Around the corners of world, cancer has ... land present over earth. Cancer has become one of ... life time this is because of the increasing incidence ... the steady increase in global cancer incidence with its ... costs of treatment, there is increasing interest in this ...
(Date:12/2/2016)... 2, 2016 The iShares Nasdaq Biotechnology ... following Trump,s victory early in November. Less political risk ... are now predicting an uptick in M&A activities. Today, ... see how they have fared at the last close: ... Therapeutics Inc. (NASDAQ: FOLD ), Navidea Biopharmaceuticals ...
Breaking Medicine Technology:
Cached News: