HOME >> MEDICINE >> NEWS
Better control of liver enzymes saves lives of HIV patients, says University Of Pittsburgh

PITTSBURGH, July 8 Mild to moderate elevations in two liver enzymes increments that are commonly ignored by most physicians are related to an increased risk of death in people with HIV, according to a University of Pittsburgh researcher who presented the findings July 8 at the XIV International AIDS Conference in Barcelona.

The enzymes are alanine transamine (ALT) and aspartamine transamine (AST).

"Up to one third of HIV patients have mild to moderate elevations in ALT and AST, yet physicians largely disregard the readings unless they are two to four times above the normal range," said Amy Justice, M.D., associate professor of health services research at the University of Pittsburgh Graduate School of Public Health, associate professor of medicine at the University of Pittsburgh School of Medicine, and staff physician at the Pittsburgh Veterans Administration Medical Center. "Our study shows that even patients whose elevations are mild to moderate have a death rate that is nearly twice that of patients with mid-range normal levels. This association with increased mortality suggests that any elevation in ALT and AST should be addressed."

Elevations in these enzymes signal injury to liver cells and, in some cases, to other cells in the body. The condition can result from highly active anti-retroviral therapy (HAART), viral hepatitis or alcohol abuse, all of which are toxic to liver cells. Liver failure is the most common cause of death in people with AIDS.

While ALT and AST testing is routine in monitoring of HIV patients, elevations are not typically addressed unless they are more than twice what is considered normal. The standard remedy for extremely high ALT and AST levels is to stop or change antiretroviral medications and to counsel patients to stop drinking alcohol. Mild to moderate elevations (0.5 up to 2 times the normal level) currently are not treated.

The Pittsburgh-led study was an analysis of data on more than 5
'"/>

Contact: Kathryn Duda
412-624-2607
University of Pittsburgh Medical Center
8-Jul-2002


Page: 1 2

Related medicine news :

1. Innovation prize finalists announced in Science of Better
2. Disaster management: Better management of hospital resources and staff is the answer
3. Better research needed to assess psychological and social effects of cannabis
4. Better predictors are needed for posttraumatic stress disorder in children
5. Better brain imaging helps surgeons avoid damage to language functions
6. Better outcome for ICU patients after removal of bacteria from digestive tract
7. Better care and better communication urgently needed
8. Better access to health care is key to higher survival rates for African-Americans with colon cancer
9. Better understanding of prognosis linked to greater emphasis on easing suffering of children with advanced cancer
10. Better diagnosis of pain in children
11. Better psychiatric support needed for children who lose a parent

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... business support services to dental groups in the United States, today announced the ... community of Beaumont, CA. , Patients will enjoy convenient hours, a comfortable ...
(Date:8/31/2020)... ... August 31, 2020 , ... Bonde Innovations, LLC, a ... advanced heart failure, today announced that the company has been awarded a Phase ... the National Heart, Lung, and Blood Institute of the National Institutes of Health ...
(Date:8/28/2020)... ... August 28, 2020 , ... With in-person ... out to continue helping the specialty-diet community connect with great, gluten-free brands. At ... coupons, enter giveaways, chat with brands & watch over 50 educational classes... all ...
(Date:8/27/2020)... ... August 27, 2020 , ... The ... a leading aesthetic and wellness retreat. The practice is centered on results and ... Las Vegas. , Designed to be a sanctuary for total body renewal ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... Bridge To A Cure Foundation announces the ... adult and pediatric neuro-oncologist who serves on the Board of Directors at The Preston ... University Medical School. , Internationally recognized, Dr. Friedman is a widely published author of ...
(Date:8/26/2020)... ... , ... AseptiScope, a privately funded San Diego, California based, clinical innovation company, ... , “AseptiScope is pleased to receive this recognition,” said Kelly Powers, AseptiScope ... their hands, goggles on their eyes, covers on their shoes, and gowns on their ...
(Date:8/26/2020)... ... August 26, 2020 , ... ... it has entered into definitive agreement to acquire ProCE, a nationally recognized ... and pharmacy technicians. , CEA represents a growing alliance of CME/CE ...
Breaking Medicine Technology:
Cached News: