HOME >> MEDICINE >> NEWS
Bevacizumab combined with chemotherapy prolongs survival for some patients with advanced lung cancer

Preliminary results from a large, randomized clinical trial for patients with previously untreated advanced non-squamous, non-small cell lung cancer show that those patients who received bevacizumab (AvastinTM) in combination with standard chemotherapy lived longer than patients who received the same chemotherapy without bevacizumab.

The clinical trial was sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and conducted by a network of researchers led by the Eastern Cooperative Oncology Group. Genentech, Inc., South San Francisco, Calif., which manufactures bevacizumab, provided bevacizumab for the trial under the Cooperative Research and Development Agreement (CRADA) with NCI for the clinical development of bevacizumab.

The Data Monitoring Committee overseeing the trial (known as E4599)* recommended that the results of a recent interim analysis be made public because the study had met its primary endpoint of improving overall survival. Researchers found that patients in the study who received bevacizumab in combination with standard chemotherapy (a treatment regimen of paclitaxel and carboplatin) had a median overall survival of 12.5 months compared to patients treated with the standard chemotherapy alone, who had a median survival of 10.2 months. This difference is statistically significant. Detailed results from this trial will be presented at the American Society of Clinical Oncology Annual Meeting (ASCO) to be held in Orlando, Fla., on May 13-17, 2005.

"The exciting results of this randomized study reveal, for the first time, an improvement in survival with the addition of a targeted agent to standard chemotherapy in this patient population," said Study Chair Alan B. Sandler, M.D., of the Vanderbilt University Medical Center in Nashville, Tenn.

"This study demonstrates that mechanistic-based interventions such as angiogenesis inhibitors are making important contribution
'"/>

Contact: NCI Press Officers
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
14-Mar-2005


Page: 1 2 3

Related medicine news :

1. Tuberculosis drug combined with virtual reality therapy is effective in treating fear of heights
2. Detrol LA combined with standard treatment for enlarged prostate is twice as effective
3. Nicotine more addictive when combined with other tobacco smoke chemicals, UCI study finds
4. Cognitive behavioral therapy combined with antidepressant effective in treating adolescent OCD
5. Heart disease kills more women annually than all cancers combined
6. Stents combined with clot-busting drugs effective in limiting impact of deadly form of stroke
7. Study shows people with Alzheimers can benefit from exercise combined with caregiver training
8. Wyeth chemists honored for Prevnar first combined pneumococcal vaccine for infants
9. Task force issues caution on combined hormone therapy
10. University of Pittsburgh research shows combined PET/CT finds cancerous lesions standard CT misses
11. Some patients are candidates for combined heart bypass, lung transplant surgeries

Post Your Comments:
(Date:3/5/2015)... Central Nebraska Imaging (CNI) is pleased to ... new logo and optimized website. , CNI’s ... to expert diagnostic imaging, centered on patient care. The ... be a resource for Nebraska patients and a tool ... and referral functionality, video content and resources to understand ...
(Date:3/5/2015)... March 05, 2015 HomeCEUConnection.com ... March with extra savings on their nutrition ... of health and nutrition, HomeCEUConnection.com is offering ... the promo code, NUTRITION2015 . , ... , HomeCEUConnection.com provides high-quality continuing education ...
(Date:3/5/2015)... On March 2, 2015, NBC News posted ... Rise, Plastic Surgeons Say,” that comments on the 2014 ... Plastic Surgery and the American Society of ... doubling of surgical butt augmentations performed in 2014. According ... this increase can be attributed to the social impact ...
(Date:3/5/2015)... In honor of National Drug Facts Week, ... and alcohol abuse in schools and communities across America, ... information on some of the dangers and statistics involved ... Institute on Drug Abuse, this annual promotion of the ... illusions that teens and young adults get from television, ...
(Date:3/5/2015)... MS (PRWEB) March 05, 2015 At ... Basics and Beyond,” leaders in addiction treatment met today ... updates in best clinical practices. Among the numerous respected ... , who will address the role that pain medications ... and new evidence-based treatment options. , "It is hard ...
Breaking Medicine News(10 mins):Health News:Central Nebraska Imaging Center Gets Rebranding 2Health News:HomeCEUConnection.com Offers Nutrition CEUs this March to Celebrate Nutrition Month 2Health News:The Kim Kardashian and Jennifer Lopez Effect: Butt Augmentations Double from 2013 to 2014 2Health News:A Forever Recovery Issues New Tips for Sobriety for National Drug Facts Week 2Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 2Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 3
(Date:3/5/2015)... -- AMRI (NASDAQ: AMRI ) announced today that ... of VP of International Sales, effective immediately. He reports ... Global Sales and Marketing. In this ... in an effort to increase worldwide customer value and ... will drive strategy for sales and marketing efforts across ...
(Date:3/5/2015)... , March 5, 2015 - ... agency ( http://www.epa.eu ) - Hitachi ... della nuova generazione di OASIS* all,ECR 2015. Si tratta ... alto campo da 1.2 T che migliora la capacità ... traguardo nell,attenzione al comfort del paziente. Le nuove funzionalità ...
(Date:3/5/2015)... March 5, 2015 Soligenix, Inc. (OTCQB: SNGX) ... committed to developing products that address unmet medical needs ... today that its President and Chief Executive Officer, ... presentation at the 27 th Annual ROTH Conference ... Tuesday, March 10, 2015 at 1:00 PM Pacific Daylight ...
Breaking Medicine Technology:AMRI Hires VP of International Sales 2Hitachi Medical Systems Europe lancia la nuova generazione di OASIS*: Il sistema di RM aperta ad alto campo da 1.2 T. Ancora più valore al paziente 2Hitachi Medical Systems Europe lancia la nuova generazione di OASIS*: Il sistema di RM aperta ad alto campo da 1.2 T. Ancora più valore al paziente 3Hitachi Medical Systems Europe lancia la nuova generazione di OASIS*: Il sistema di RM aperta ad alto campo da 1.2 T. Ancora più valore al paziente 4Soligenix to Present at the 27th Annual ROTH Conference 2Soligenix to Present at the 27th Annual ROTH Conference 3
Cached News: